Publication: Effects of neuronotrophic factors on adrenal medulla grafts implanted into adult rat brains
Date
Authors
Korfalı, Ender
Doygun, Muammer
Ulus, İsmail Hakkı
Aksoy, Kaya
Authors
Rakunt, Cemil
Advisor
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Oxford Univ Press
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Abstract
The effects of neuronotrophic factors (NFs) on adult adrenal medulla grafts transplanted into the rat caudate nucleus after the destruction of the nigrostriatal dopaminergic pathways were investigated. Two months after implantation, all of the adrenal medulla grafts treated with NFs, but only 45% of the untreated grafts, had survived. The levels of tyrosine hydroxylase activity in the caudate nucleus however, were not significantly different between the sham-operated control and either NF-treated or untreated grafted groups. These results indicate that treatment with NFs significantly enhances the survival rate of the grafts.
Description
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Keywords
Neurosciences & neurology, Surgery, Corpus striatum, Tyrosine hydroxylase, Adrenal medulla, Transplantation, Reinnervation, Brain graft
Citation
Korfalı, E. vd. (1988). ''Effects of neuronotrophic factors on adrenal medulla grafts implanted into adult rat brains''. Neurosurgery, 22(6), 994-998.