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Changes in salivary analytes in canine parvovirus: A high-resolution quantitative proteomic study

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dc.contributor.authorFranco-Martínez, Lorena
dc.contributor.authorTvarijonaviciute, Asta
dc.contributor.authorHorvatić, Anita
dc.contributor.authorGuillemin, Nicolas
dc.contributor.authorCerón, José Joaquín
dc.contributor.authorEscribano, Damián
dc.contributor.authorEckersall, David
dc.contributor.authorLamy, Elsa
dc.contributor.authorMartínez-Subiela, Silvia
dc.contributor.authorMrljak, Vladimir
dc.contributor.buuauthorKocatürk, Meriç
dc.contributor.buuauthorYılmaz, Zeki
dc.contributor.departmentVeterinerlik Fakültesi
dc.contributor.departmentDahiliye Ana Bilim Dalı
dc.contributor.orcid0000-0001-9836-0749
dc.contributor.researcheridV-5578-2017
dc.contributor.scopusid36437200800
dc.contributor.scopusid35944810500
dc.date.accessioned2022-12-28T08:50:33Z
dc.date.available2022-12-28T08:50:33Z
dc.date.issued2018-09-18
dc.description.abstractThe present study evaluated the changes in salivary proteome in parvoviral enteritis (PVE) in dogs through a high-throughput quantitative proteomic analysis. Saliva samples from healthy dogs and dogs with severe parvovirosis that survived or perished due to the disease were analysed and compared by Tandem Mass Tags (TMT) analysis. Proteomic analysis quantified 1516 peptides, and 287 (corresponding to 190 proteins) showed significantly different abundances between studied groups. Ten proteins were observed to change significantly between dogs that survived or perished due to PVE. Bioinformatics' analysis revealed that saliva reflects the involvement of different pathways in PVE such as catalytic activity and binding, and indicates antimicrobial humoral response as a pathway with a major role in the development of the disease. These results indicate that saliva proteins reflect physiopathological changes that occur in PVE and could be a potential source of biomarkers for this disease.
dc.description.sponsorshipFPU of University of Murcia, Spain
dc.description.sponsorshipMinisterio de Economia y Competitividad, Spain
dc.description.sponsorshipProgram for Research Groups of Excellence of the Seneca Foundation, Murcia, Spain (19894/GERM/15)
dc.description.sponsorshipEuropean Commission ERA chair FP7 grant (621394)
dc.identifier.citationFranco-Martínez, L. vd. (2018). ''Changes in salivary analytes in canine parvovirus: A high-resolution quantitative proteomic study''. Comparative Immunology, Microbiology and Infectious Diseases, 60, 1-10.
dc.identifier.doi10.1016/j.cimid.2018.09.011
dc.identifier.endpage10
dc.identifier.issn0147-9571
dc.identifier.issn1878-1667
dc.identifier.pubmed30396423
dc.identifier.scopus2-s2.0-85054338485
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.1016/j.cimid.2018.09.011
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0147957118300742
dc.identifier.urihttp://hdl.handle.net/11452/30129
dc.identifier.volume60
dc.identifier.wos000449071800001
dc.indexed.scopusScopus
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherElsevier
dc.relation.collaborationYurt dışı
dc.relation.journalComparative Immunology, Microbiology and Infectious Diseases
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectImmunology
dc.subjectMicrobiology
dc.subjectVeterinary sciences
dc.subjectBioinformatics
dc.subjectBiomarker
dc.subjectCanine parvovirosis
dc.subjectDog
dc.subjectLabel-based proteomics
dc.subjectSaliva
dc.subjectHistidine-rich glycoprotein
dc.subjectAcute-phase proteins
dc.subjectDogs
dc.subjectBiomarkers
dc.subjectInfection
dc.subjectIdentification
dc.subjectDiagnosis
dc.subjectEnteritis
dc.subjectLipocalin
dc.subjectSerum
dc.subject.emtreeAlpha actinin 1
dc.subject.emtreeAmikacin
dc.subject.emtreeAmpicillin
dc.subject.emtreeApolipoprotein A1
dc.subject.emtreeBiological marker
dc.subject.emtreeBPI fold containing family B member 2 protein
dc.subject.emtreeCathelicidin antimicrobial peptide
dc.subject.emtreeCD177 antigen
dc.subject.emtreeClusterin
dc.subject.emtreeCystatin M
dc.subject.emtreeEF hand domain containing protein D2
dc.subject.emtreeEzrin
dc.subject.emtreeGelatinase B
dc.subject.emtreeGlutathione derivative
dc.subject.emtreeHemoglobin beta chain
dc.subject.emtreeImmunoglobulin heavy chain
dc.subject.emtreeLactoperoxidase
dc.subject.emtreeLactoylglutathione lyase
dc.subject.emtreeLeukocyte elastase
dc.subject.emtreeLipocalin 9
dc.subject.emtreeMetronidazole
dc.subject.emtreePlastin 2
dc.subject.emtreeProteome
dc.subject.emtreeRetinol binding protein 4
dc.subject.emtreeRho GDP dissociation inhibitor beta protein
dc.subject.emtreeSaliva protein
dc.subject.emtreeTrefoil factor 1
dc.subject.emtreeUbiquitin C
dc.subject.emtreeUnclassified drug
dc.subject.emtreeUnindexed drug
dc.subject.emtreeVitamin D binding protein
dc.subject.emtreeBiological marker
dc.subject.emtreeSaliva protein
dc.subject.emtreeArticle
dc.subject.emtreeBioinformatics
dc.subject.emtreeCanine parvovirus
dc.subject.emtreeCatalysis
dc.subject.emtreeControlled study
dc.subject.emtreeDisease severity
dc.subject.emtreeDog
dc.subject.emtreeDown regulation
dc.subject.emtreeFemale
dc.subject.emtreeHigh resolution quantitative proteomic analysis
dc.subject.emtreeHigh throughput screening
dc.subject.emtreeHumoral immunity
dc.subject.emtreeMale
dc.subject.emtreeNonhuman
dc.subject.emtreeParvovirosis
dc.subject.emtreeParvovirus infection
dc.subject.emtreePathophysiology
dc.subject.emtreeProtein analysis
dc.subject.emtreeProtein binding
dc.subject.emtreeProtein expression
dc.subject.emtreeProtein function
dc.subject.emtreeProteomics
dc.subject.emtreeQuantitative analysis
dc.subject.emtreeSaliva
dc.subject.emtreeSaliva analysis
dc.subject.emtreeSurvival
dc.subject.emtreeTandem mass spectrometry
dc.subject.emtreeTandem Mass Tags based proteomic analysis
dc.subject.emtreeUpregulation
dc.subject.emtreeAnimal
dc.subject.emtreeBiology
dc.subject.emtreeCanine parvovirus
dc.subject.emtreeChemistry
dc.subject.emtreeDog disease
dc.subject.emtreeEnteritis
dc.subject.emtreeImmunology
dc.subject.emtreeIsolation and purification
dc.subject.emtreeMortality
dc.subject.emtreeParvovirus infection
dc.subject.emtreeProteomics
dc.subject.emtreeSaliva
dc.subject.emtreeVeterinary medicine
dc.subject.emtreeVirology
dc.subject.meshAnimals
dc.subject.meshBiomarkers
dc.subject.meshComputational biology
dc.subject.meshDog diseases
dc.subject.meshDogs
dc.subject.meshEnteritis
dc.subject.meshFemale
dc.subject.meshMale
dc.subject.meshParvoviridae infections
dc.subject.meshParvovirus, canine
dc.subject.meshProteomics
dc.subject.meshSaliva
dc.subject.meshSalivary proteins and peptides
dc.subject.scopusCanine Parvovirus; Feline Panleukopenia Virus; Dog
dc.subject.wosImmunology
dc.subject.wosMicrobiology
dc.subject.wosVeterinary sciences
dc.titleChanges in salivary analytes in canine parvovirus: A high-resolution quantitative proteomic study
dc.typeArticle
dc.wos.quartileQ1 (Veterinary sciences)
dc.wos.quartileQ4
dc.wos.quartileQ1
dc.wos.quartileQ4
dspace.entity.typePublication
local.contributor.departmentVeterinerlik Fakültesi/Dahiliye Ana Bilim Dalı
local.indexed.atPubMed
local.indexed.atWOS
local.indexed.atScopus

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