Publication:
A nationwide multicentre study in Turkey for establishing reference intervals of haematological parameters with novel use of a panel of whole blood

dc.contributor.buuauthorÖzarda, Yeşim
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıbbi Biyokimya Ana Bilim Dalı
dc.contributor.researcheridAAL-8873-2021
dc.contributor.scopusid35741320500
dc.date.accessioned2023-09-19T13:04:35Z
dc.date.available2023-09-19T13:04:35Z
dc.date.issued2017
dc.descriptionÇalışmada 29 yazar bulunmaktadır. Bu yazarlardan sadece Bursa Uludağ Üniversitesi mensuplarının girişleri yapılmıştır.
dc.description.abstractIntroduction: A nationwide multicentre study was conducted to establish well-defined reference intervals (Rls) of haematological parameters for the Turkish population in consideration of sources of variation in reference values (RVs). Materials and methods: K2-EDTA whole blood samples (total of 3363) were collected from 12 laboratories. Sera were also collected for measurements of iron, UIBC, TIBC, and ferritin for use in the latent abnormal values exclusion (LAVE) method. The blood samples were analysed within 2 hours in each laboratory using Cell Dyn and Ruby (Abbott), LH780 (Beckman Coulter), or XT-2000i (Sysmex). A panel of freshly prepared blood from 40 healthy volunteers was measured in common to assess any analyser-dependent bias in the measurements. The SD ratio (SDR) based on ANOVA was used to judge the need for partitioning RVs. Rls were computed by the parametric method with/without applying the LAVE method. Results: Analyser-dependent bias was found for basophils (Bas), MCHC, RDW and MPV from the panel test results and thus those Rls were derived for each manufacturer. Rls were determined from all volunteers' results for WBC, neutrophils, lymphocytes, monocytes, eosinophils, MCV, MCH and platelets. Gender-specific Rls were required for RBC, haemoglobin, haematocrit, iron, UIBC and ferritin. Region-specific Rls were required for RBC, haemoglobin, haematocrit, UIBC, and TIBC. Conclusions: With the novel use of a freshly prepared blood panel, manufacturer-specific Rls' were derived for Bas, Bas%, MCHC, RDW and MPV. Regional differences in Rls were observed among the 7 regions of Turkey, which may be attributed to nutritional or environmental factors, including altitude.
dc.description.sponsorshipAbbott Diagnostics (Abbott Laboratories, IL, USA)
dc.description.sponsorshipBecton Dickinson (BD Diagnostics, Oxford, England)
dc.description.sponsorshipMinistry of Education, Culture, Sports, Science and Technology, Japan (MEXT) Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research (KAKENHI) - 16H02771
dc.identifier.citationÖzarda, Y. vd. (2017). ''A nationwide multicentre study in Turkey for establishing reference intervals of haematological parameters with novel use of a panel of whole blood''. Biochemia Medica, 27(2), 350-377.
dc.identifier.endpage2
dc.identifier.issn1330-0962
dc.identifier.issn1846-7482
dc.identifier.issue377
dc.identifier.pubmed28694726
dc.identifier.scopus2-s2.0-85020689126
dc.identifier.startpage27
dc.identifier.urihttps://doi.org/10.11613/BM.2017.038
dc.identifier.urihttps://www.biochemia-medica.com/en/journal/27/2/10.11613/BM.2017.038
dc.identifier.urihttp://hdl.handle.net/11452/33908
dc.identifier.volume350
dc.identifier.wos000404505700013
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherCroatian Soc Medical Biochemistry & Laboratory Medicine
dc.relation.bapUAP(T)-2011/48
dc.relation.collaborationYurt içi
dc.relation.journalBiochemia Medica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectMedical laboratory technology
dc.subjectMulticentre study
dc.subjectReference intervals
dc.subjectComplete blood count
dc.subjectHaematology
dc.subjectTurkey
dc.subjectWorldwide multicenter
dc.subjectGlobal multicenter
dc.subjectCell counts
dc.subjectAnalytes
dc.subjectAltitude
dc.subjectIndexes
dc.subjectAdult
dc.subject.emtreeFerritin
dc.subject.emtreeAdult
dc.subject.emtreeAged
dc.subject.emtreeAnalytical parameters
dc.subject.emtreeArticle
dc.subject.emtreeBlood clotting
dc.subject.emtreeBlood sampling
dc.subject.emtreeFemale
dc.subject.emtreeHematological parameters
dc.subject.emtreeHuman
dc.subject.emtreeMale
dc.subject.emtreeMiddle aged
dc.subject.emtreeMulticenter study
dc.subject.emtreeQuality control
dc.subject.emtreeQuestionnaire
dc.subject.emtreeRed blood cell distribution width
dc.subject.emtreeReference value
dc.subject.emtreeAdolescent
dc.subject.emtreeBlood cell count
dc.subject.emtreeBlood examination
dc.subject.emtreeClinical trial
dc.subject.emtreeDevices
dc.subject.emtreeGood laboratory practice
dc.subject.emtreeLaboratory
dc.subject.emtreeProcedures
dc.subject.emtreeReference value
dc.subject.emtreeRegression analysis
dc.subject.emtreeReproducibility
dc.subject.emtreeStandards
dc.subject.emtreeTurkey
dc.subject.emtreeYoung adult
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshBlood cell count
dc.subject.meshFemale
dc.subject.meshHematologic tests
dc.subject.meshLaboratories
dc.subject.meshHumans
dc.subject.meshLaboratory proficiency testing
dc.subject.meshMale
dc.subject.meshMiddle aged
dc.subject.meshQuality control
dc.subject.meshReference values
dc.subject.meshRegression analysis
dc.subject.meshReproducibility of results
dc.subject.meshTurkey
dc.subject.meshYoung adult
dc.subject.scopusClinical Chemistry; Thyrotropin; Chemical Species
dc.subject.wosMedical laboratory technology
dc.titleA nationwide multicentre study in Turkey for establishing reference intervals of haematological parameters with novel use of a panel of whole blood
dc.typeArticle
dc.wos.quartileQ1
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Tıbbi Biyokimya Ana Bilim Dalı
local.indexed.atScopus
local.indexed.atWOS

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