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The expressions of pAkt and PTEN in lung cancer patients 24 hours after the cisplatin-based chemotherapy: A prospective pilot study

dc.contributor.authorYağcı, Artay
dc.contributor.authorSevimli, Alper
dc.contributor.buuauthorUlukaya, Engin
dc.contributor.buuauthorOral, Arzu Yılmaztepe
dc.contributor.buuauthorZık, Berrin
dc.contributor.buuauthorArı, Ferda
dc.contributor.buuauthorAkgöz, Semra
dc.contributor.buuauthorUrsavaş, Ahmet
dc.contributor.buuauthorBayer, Sibel
dc.contributor.departmentVeterinerlik Fakültesi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentFen Edebiyat Fakültesi
dc.contributor.departmentTB ve Göğüs Hastalıkları Ana Bilim Dalı
dc.contributor.departmentBiyokimya Ana Bilim Dalı
dc.contributor.departmentBiyoloji Ana Bilim Dalı
dc.contributor.departmentHistoloji ve Embriyoloji Ana Bilim Dalı
dc.contributor.orcid0000-0002-6729-7908
dc.contributor.orcid0000-0003-0463-6818
dc.contributor.researcheridK-5792-2018
dc.contributor.researcheridAAI-3169-2021
dc.contributor.researcheridAAH-9810-2021
dc.contributor.researcheridAAG-7012-2021
dc.contributor.researcheridA-5841-2017
dc.contributor.scopusid6602927353
dc.contributor.scopusid23091316500
dc.contributor.scopusid6507763192
dc.contributor.scopusid24376085300
dc.contributor.scopusid14061863400
dc.contributor.scopusid8329319900
dc.contributor.scopusid57215362032
dc.date.accessioned2022-06-21T07:45:05Z
dc.date.available2022-06-21T07:45:05Z
dc.date.issued2011
dc.description.abstractAkt/PKB is a protooncogen while PTEN is a tumor suppressor gene. Their expressions are of immense importance in the development of lung cancer. However, little is known about their relations to anti-cancer treatments. Therefore, we aimed to elucidate how are these parameters affected by the treatment. Expression of phosphorylated Akt (pAkt) and PTEN have been analysed on tissues of 32 patients (stage Ill and IV) with lung cancer. In addition, the expression of these variables in 14 out of 32 patients have furtherly been analysed in terms of their response to cisplatin-based chemotherapy in vivo. Prior to and 24 h after the treatment, tumor tissues were obtained via broncoscopy and then evaluated immunohistochemically by indirect streptavidin-biotin peroxidase method. Immunoreactivity for pAkt was detected in 29 of 32 cases (91%). pAkt was observed to localize in the nucleus of positively stained cells. However, PTEN expression was found in 27 of 32 cases (84%). In contrast to the localization of pAkt that is nucleus, PTEN was however localized in the cytoplasm of positively stained cells. pAkt and PTEN expression levels of 14 post-chemotherapy patients were compared to those before chemotherapy. There was no statistically significant differences (p>0.05). Although these results do not imply any possible roles of pAkt or PTEN in the late stage lung cancer patients as a biomarker for the prediction of early response to treatment in vivo, this conclusion needs to be analyzed further at later time points in a larger cohort.
dc.identifier.citationUlukaya, E. vd. (2011). "The expressions of pAkt and PTEN in lung cancer patients 24 hours after the cisplatin-based chemotherapy: A prospective pilot study". UHOD - Uluslararasi Hematoloji-Onkoloji Dergisi, 21(1), 26-33.
dc.identifier.endpage33
dc.identifier.issn1306-133X
dc.identifier.issue1
dc.identifier.scopus2-s2.0-79953677217
dc.identifier.startpage26
dc.identifier.urihttps://doi.org/10.4999/uhod.09105
dc.identifier.urihttp://www.uhod.org/pdf/PDF_451.pdf
dc.identifier.urihttp://hdl.handle.net/11452/27331
dc.identifier.volume21
dc.identifier.wos000289140000004
dc.indexed.scopusScopus
dc.indexed.trdizinTrDizin
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherAkad Doktorlar Yayınevi
dc.relation.collaborationYurt içi
dc.relation.collaborationSanayi
dc.relation.journalUHOD - Uluslararasi Hematoloji-Onkoloji Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectOncology
dc.subjectLung Cancer
dc.subjectpAkt
dc.subjectPTEN
dc.subjectCisplatin
dc.subjectChemotherapy
dc.subjectProtein-kinase-b
dc.subjectPrognostic-significance
dc.subjectAkt activation
dc.subjectBreast-cancer
dc.subjectCell-death
dc.subjectApoptosis
dc.subjectTumors
dc.subjectMechanisms
dc.subjectSurvival
dc.subjectGene
dc.subjectAkciğer kanseri
dc.subjectKemoterapi
dc.subjectSisplatin
dc.subject.emtreeBiotin
dc.subject.emtreeCisplatin
dc.subject.emtreeEtoposide
dc.subject.emtreeGemcitabine
dc.subject.emtreeNavelbine
dc.subject.emtreePhosphatidylinositol 3,4,5 trisphosphate 3 phosphatase
dc.subject.emtreeProtein kinase B
dc.subject.emtreeStreptavidin
dc.subject.emtreeArticle
dc.subject.emtreeBronchoscopy
dc.subject.emtreeCancer tissue
dc.subject.emtreeClinical article
dc.subject.emtreeControlled study
dc.subject.emtreeEnzyme localization
dc.subject.emtreeHuman
dc.subject.emtreeHuman tissue
dc.subject.emtreeImmunohistochemistry
dc.subject.emtreeLung non small cell cancer
dc.subject.emtreeLung small cell cancer
dc.subject.emtreePilot study
dc.subject.emtreeProtein expression
dc.subject.emtreeProtein phosphorylation
dc.subject.scopusMK 2206; 3 Phosphoinositide Dependent Protein Kinase; Phosphatidylinositols
dc.subject.wosOncology
dc.titleThe expressions of pAkt and PTEN in lung cancer patients 24 hours after the cisplatin-based chemotherapy: A prospective pilot study
dc.title.alternativeAkciǧer kanserli hastalarda sisplatin-Bazlı tedaviden 24 saat sonra pAkt ve PTEN ekspresyonları: Prospektif pilot çalışma
dc.typeArticle
dc.wos.quartileQ4
dspace.entity.typePublication
local.contributor.departmentFen Edebiyat Fakültesi/Biyoloji Ana Bilim Dalı
local.contributor.departmentVeterinerlik Fakültesi/Histoloji ve Embriyoloji Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Biyokimya Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/TB ve Göğüs Hastalıkları Ana Bilim Dalı
local.indexed.atWOS
local.indexed.atScopus

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