Publication:
Inhibitory effect of methotrexate (MTX) used in human cancer treatment on paraoxonase-1 (PON1)

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dc.contributor.authorSöyüt, Hakan
dc.contributor.authorUlutaş, Yakup
dc.contributor.authorKöksal, Ekrem
dc.contributor.buuauthorSÖYÜT, HAKAN
dc.contributor.departmentEğitim Fakültesi
dc.contributor.departmentİlköğretim Bölümü
dc.contributor.researcheridAAE-6795-2019
dc.date.accessioned2024-11-19T10:59:35Z
dc.date.available2024-11-19T10:59:35Z
dc.date.issued2022-01-01
dc.description.abstractBackground and Objective: Paraoxonase-1 (PON1) is a lactonase that plays a role in the destruction of carcinogenic free radicals and in reducing oxidative stress. In this article, it was aimed to investigate the inhibitory effect of methotrexate (MTX) on PON1. Materials and Methods: In this study, the inhibition between methotrexate used in cancer chemotherapy and PON1 was studied. Results: Methotrexate showed very strong inhibitory properties for human serum PON1, with an IC(50)value of 38.50 mu M and a mean K-i value of 42.36 mu M. Hence methotrexate showed competitive inhibition. Conclusion: The widespread use of methotrexate, a dihydrofolate reductase (DHFR) inhibitor, in the treatment of human cancers can be very harmful.
dc.identifier.doi10.3923/ijp.2022.942.946
dc.identifier.endpage946
dc.identifier.issn1811-7775
dc.identifier.issue5
dc.identifier.startpage942
dc.identifier.urihttps://doi.org/10.3923/ijp.2022.942.946
dc.identifier.urihttps://scialert.net/abstract/?doi=ijp.2022.942.946
dc.identifier.urihttps://hdl.handle.net/11452/48096
dc.identifier.volume18
dc.identifier.wos000859917600011
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherAsian Network Scientific Information-Ansinet
dc.relation.journalInternational Journal of Pharmacology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectHuman serum paraoxonase-1
dc.subjectOxidative stress
dc.subjectHydrochloride
dc.subjectHpon1
dc.subjectPon1
dc.subjectMethotrexate
dc.subjectInhibition
dc.subjectAnticancer drug
dc.subjectOxidative stress
dc.subjectLdl
dc.subjectAtherosclerosis
dc.subjectPharmacology & pharmacy
dc.titleInhibitory effect of methotrexate (MTX) used in human cancer treatment on paraoxonase-1 (PON1)
dc.typeArticle
dspace.entity.typePublication
local.contributor.departmentEğitim Fakültesi/İlköğretim Bölümü
local.indexed.atWOS
relation.isAuthorOfPublication71fcc315-c95c-4f00-898e-183c34d8b375
relation.isAuthorOfPublication.latestForDiscovery71fcc315-c95c-4f00-898e-183c34d8b375

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