Publication:
RAB25 confers resistance to chemotherapy by altering mitochondrial apoptosis signaling in ovarian cancer cells

Simple item page
dc.contributor.authorGiray, Aslı
dc.contributor.authorKarakaş, Bahriye
dc.contributor.authorGül, Özgür
dc.contributor.authorKozanoğlu, İlknur
dc.contributor.authorÇelik, Hüsnü
dc.contributor.authorBaşağa, Hüveyda
dc.contributor.authorAçıkbaş, Ufuk
dc.contributor.authorSuçularlı, Ceren
dc.contributor.authorÖztop, Sıdıka
dc.contributor.authorAka, Yeliz
dc.contributor.authorKütük, Özgür
dc.contributor.buuauthorTemel, Şehime Gülsün
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıbbi Genetik Bölümü
dc.contributor.orcid0000-0002-9802-0880
dc.contributor.researcheridAAG-8385-2021
dc.contributor.scopusid6507885442
dc.date.accessioned2023-11-09T06:40:13Z
dc.date.available2023-11-09T06:40:13Z
dc.date.issued2020-12
dc.description.abstractOvarian cancer remains one of the most frequent causes of cancer-related death in women. Many patients with ovarian cancer suffer from de novo or acquired resistance to chemotherapy. Here, we report that RAB25 suppresses chemotherapy-induced mitochondrial apoptosis signaling in ovarian cancer cell lines and primary ovarian cancer cells. RAB25 blocks chemotherapy-induced apoptosis upstream of mitochondrial outer membrane permeabilization by either increasing antiapoptotic BCL-2 proteins or decreasing proapoptotic BCL-2 proteins. In particular, BAX expression negatively correlates with RAB25 expression in ovarian cancer cells. BH3 profiling assays corroborated that RAB25 decreases mitochondrial cell death priming. Suppressing RAB25 by means of RNAi or RFP14 inhibitory hydrocarbon-stapled peptide sensitizes ovarian cancer cells to chemotherapy as well as RAB25-mediated proliferation, invasion and migration. Our data suggest that RAB25 is a potential therapeutic target for ovarian cancer.
dc.description.sponsorshipTürkiye Bilimsel ve Teknolojik Araştırma Kurumu (TUBITAK) (113S871)
dc.description.sponsorshipBaşkent Üniversitesi
dc.description.sponsorshipScience Academy BAGEP program
dc.identifier.citationTemel, S. G. vd. (2020). ''RAB25 confers resistance to chemotherapy by altering mitochondrial apoptosis signaling in ovarian cancer cells''. Apoptosis, 25(11-12), 799-816.
dc.identifier.endpage816
dc.identifier.issn1360-8185
dc.identifier.issn1573-675X
dc.identifier.issue11-12
dc.identifier.pubmed32901335
dc.identifier.scopus2-s2.0-85090440803
dc.identifier.startpage799
dc.identifier.urihttps://doi.org/10.1007/s10495-020-01635-z
dc.identifier.urihttps://link.springer.com/article/10.1007/s10495-020-01635-z
dc.identifier.urihttp://hdl.handle.net/11452/34812
dc.identifier.volume25
dc.identifier.wos000567421400001
dc.indexed.scopusScopus
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherSpringer
dc.relation.collaborationYurt içi
dc.relation.journalApoptosis
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.relation.tubitakTÜBİTAK
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectRab25
dc.subjectChemotherapy
dc.subjectBcl-2 proteins
dc.subjectOvarian cancer
dc.subjectBcl-2
dc.subjectExpression
dc.subjectMetasis
dc.subjectInhibition
dc.subjectInvasion
dc.subjectOverexpression
dc.subjectProliferation
dc.subjectContributes
dc.subjectBiomarkers
dc.subjectKidney
dc.subjectBiochemistry & molecular biology
dc.subjectCell biology
dc.subject.emtreeBh3 protein
dc.subject.emtreeBim protein
dc.subject.emtreeCarboplatin
dc.subject.emtreeCaspase 3
dc.subject.emtreeCapace 9
dc.subject.emtreeEtoposide
dc.subject.emtreeHydrocarbon
dc.subject.emtreePaclitaxel
dc.subject.emtreeProtein bax
dc.subject.emtreeProtein bcl 2
dc.subject.emtreeProtein mcl 1
dc.subject.emtreeProtein noxa
dc.subject.emtreePuma protein
dc.subject.emtreeRab protein
dc.subject.emtreeRab25 protein
dc.subject.emtreeUnclassified drug
dc.subject.emtreeProtein bcl 2
dc.subject.emtreeRab protein
dc.subject.emtreeRab25 protein, human
dc.subject.emtreeAdult
dc.subject.emtreeAged
dc.subject.emtreeAmino acid sequence
dc.subject.emtreeApoptosis
dc.subject.emtreeApoptosis assey
dc.subject.emtreeArticle
dc.subject.emtreeCancer cell
dc.subject.emtreeCancer combination chemotherapy
dc.subject.emtreeCancer grading
dc.subject.emtreeCancer patient
dc.subject.emtreeCancer resistance
dc.subject.emtreeCell fractionation
dc.subject.emtreeCell invasion
dc.subject.emtreeCell migration
dc.subject.emtreeCell proliferation
dc.subject.emtreeCell proliferation assay
dc.subject.emtreeCell viability
dc.subject.emtreeChemoluminescence
dc.subject.emtreeClinical article
dc.subject.emtreeControlled study
dc.subject.emtreeData analysis software
dc.subject.emtreeFemale
dc.subject.emtreeFlow cytometry
dc.subject.emtreeFluorometry
dc.subject.emtreeGene expression level
dc.subject.emtreeHEY A8 cell line
dc.subject.emtreeHistology
dc.subject.emtreeHuman
dc.subject.emtreeHuman cell
dc.subject.emtreeHuman tissue
dc.subject.emtreeIgrov-1 cell line
dc.subject.emtreeLow drug dose
dc.subject.emtreeMitochondrion
dc.subject.emtreeOuter membrane
dc.subject.emtreeOvary cancer
dc.subject.emtreeOvcar-3 cell line
dc.subject.emtreeOvcar-4 cell line
dc.subject.emtreeOvcar-5 cell line
dc.subject.emtreeOvcar-8 cell line
dc.subject.emtreeOverall survival
dc.subject.emtreePolyacrylamide gel electrophoresis
dc.subject.emtreePriority journal
dc.subject.emtreeProgression free survival
dc.subject.emtreeProtein depletion
dc.subject.emtreeProtein expression
dc.subject.emtreeProtein isolation
dc.subject.emtreeReal time polymerase chain reaction
dc.subject.emtreeRna interference
dc.subject.emtreeScanning electron microscopy
dc.subject.emtreeSk-ov-3 cell line
dc.subject.emtreeThree dimensional cell culture
dc.subject.emtreeTov-112D cell line
dc.subject.emtreeCell cycle
dc.subject.emtreeCell motion
dc.subject.emtreeDrug resistance
dc.subject.emtreeMetabolism
dc.subject.emtreeMiddle aged
dc.subject.emtreeMitochondrion
dc.subject.emtreeOvary tumor
dc.subject.emtreePathology
dc.subject.emtreePhysiology
dc.subject.emtreeSignal transduction
dc.subject.emtreeTumor cell line
dc.subject.emtreeTumor invasion
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshApoptosis
dc.subject.meshCell cycle
dc.subject.meshCell line
dc.subject.meshTumor
dc.subject.meshCell movement
dc.subject.meshCell proliferation
dc.subject.meshDrug resistance
dc.subject.meshNeoplasm
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshMiddle aged
dc.subject.meshMitochondria
dc.subject.meshNeoplasm invasiveness
dc.subject.meshOvarian neoplasms
dc.subject.meshProto-oncogene proteins c-bcl-2
dc.subject.meshRab gtp-binding proteins
dc.subject.meshSignal transduction
dc.subject.scopusRab GTP-binding Protein; Carrier Proteins; Endosomes
dc.subject.wosBiochemistry & molecular biology
dc.subject.wosCell biology
dc.titleRAB25 confers resistance to chemotherapy by altering mitochondrial apoptosis signaling in ovarian cancer cells
dc.typeArticle
dc.wos.quartileQ2
dc.wos.quartileQ2
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Tıbbi Genetik Bölümü
local.indexed.atPubMed
local.indexed.atWOS
local.indexed.atScopus

Files

License bundle

Now showing 1 - 1 of 1
Placeholder
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

İndeksli Yayınlar / Indexed Publications