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Does sphingosine-1-phosphate have a protective effect on cyclophosphamide- and irradiation-induced ovarian damage in the rat model?

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dc.contributor.authorKaya, Hakan
dc.contributor.authorDesdicioğlu, Raziye
dc.contributor.authorSezik, Mekin
dc.contributor.authorÖzkaya, Okan
dc.contributor.buuauthorUlukaya, Engin
dc.contributor.buuauthorYımaztepe, Arzu
dc.contributor.buuauthorDemirci, Meral
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentBiyokimya Ana Bilim Dalı
dc.contributor.researcheridK-5792-2018
dc.contributor.scopusid6602927353
dc.contributor.scopusid8606136100
dc.contributor.scopusid18534643800
dc.date.accessioned2021-12-20T09:06:17Z
dc.date.available2021-12-20T09:06:17Z
dc.date.issued2008-03
dc.description.abstractThe aim of this study was to assess the possible protective effect of sphingosine-1-phosphate (S1P), a polar sphingoid metabolite that seemingly promotes cell survival, on cytotoxin- and irradiation-induced ovarian injury in the rat model. Administration of S I P into ovarian bursa before whole-body irradiation led to decreased percentage of apoptotic cells, mostly in primordial follicles; however, S1P was not effective against apoptosis in rats that were given intraperitoneal cyclophosphamide.
dc.description.sponsorshipSüleyman Demirel Üniversitesi
dc.identifier.citationKaya, H. vd. (2008). ''Does sphingosine-1-phosphate have a protective effect on cyclophosphamide- and irradiation-induced ovarian damage in the rat model?''. Fertility and Sterility, 89(3), 732-735.
dc.identifier.doi10.1016/j.fertnstert.2007.03.065
dc.identifier.endpage735
dc.identifier.issn0015-0282
dc.identifier.issn1556-5653
dc.identifier.issue3
dc.identifier.pubmed17517398
dc.identifier.scopus2-s2.0-40249114895
dc.identifier.startpage732
dc.identifier.urihttps://doi.org/10.1016/j.fertnstert.2007.03.065
dc.identifier.urihttps://www.sciencedirect.com/science/article/abs/pii/S0015028207007947
dc.identifier.urihttp://hdl.handle.net/11452/23409
dc.identifier.volume89
dc.identifier.wos000254026700037
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherElsevier
dc.relation.collaborationYurt içi
dc.relation.collaborationSanayi
dc.relation.journalFertility and Sterility
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectOocyte apoptosis
dc.subjectActivation
dc.subjectSurvival
dc.subjectChemotherapy
dc.subjectFollicles
dc.subjectGranulosa
dc.subjectCaspase-3
dc.subjectAcid
dc.subjectObstetrics & gynecology
dc.subjectReproductive biology
dc.subject.emtreeCyclophosphamide
dc.subject.emtreeCytotoxin
dc.subject.emtreeDrug metabolite
dc.subject.emtreeSphingosine 1 phosphate
dc.subject.emtreeAnimal cell
dc.subject.emtreeAnimal experiment
dc.subject.emtreeAnimal model
dc.subject.emtreeAnimal tissue
dc.subject.emtreeApoptosis
dc.subject.emtreeArticle
dc.subject.emtreeCell survival
dc.subject.emtreeControlled study
dc.subject.emtreeDrug effect
dc.subject.emtreeFemale
dc.subject.emtreeNonhuman
dc.subject.emtreeOvary
dc.subject.emtreeOvary disease
dc.subject.emtreeOvary follicle
dc.subject.emtreePriority journal
dc.subject.emtreeProtection
dc.subject.emtreeRat
dc.subject.emtreeWhole body radiation
dc.subject.meshAnimals
dc.subject.meshAntineoplastic agents, alkylating
dc.subject.meshApoptosis
dc.subject.meshCyclophosphamide
dc.subject.meshDisease models, animal
dc.subject.meshFemale
dc.subject.meshInjections, intraperitoneal
dc.subject.meshLysophospholipids
dc.subject.meshOvarian diseases
dc.subject.meshOvarian follicle
dc.subject.meshOvulation induction
dc.subject.meshRadiation injuries, experimental
dc.subject.meshRats
dc.subject.meshRats, wistar
dc.subject.meshSphingosine
dc.subject.meshWhole-body irradiation
dc.subject.scopusFertility Preservation; Ovulation Induction; Vitrification
dc.subject.wosObstetrics & gynecology
dc.subject.wosReproductive biology
dc.titleDoes sphingosine-1-phosphate have a protective effect on cyclophosphamide- and irradiation-induced ovarian damage in the rat model?
dc.typeArticle
dc.type.subtypeEditorial Material
dc.wos.quartileQ1
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Biyokimya Ana Bilim Dalı
local.indexed.atPubMed
local.indexed.atWOS

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