Publication: Computer-aided prediction and cytotoxicity evaluation of dithiocarbamates of 9,10-anthracenedione as new anticancer agents
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Authors
Akgün, Oğuzhan
Authors
Stasevych, Maryna
Zvarych, Viktor
Lunin, Volodymyr
Deniz, Nahide Gülşah
Gökmen, Zeliha
Ulukaya, Engin
Poroikov, V.
Gloriozova, Tatyana
Novikov, Volodymyr
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Taylor & Francis
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Abstract
Anticancer activity as an associated action for a series of dithiocarbamates of 9,10-anthracenedione was predicted using the PASS computer program and analysed with PharmaExpert software. The predicted cytotoxic activity of the dithiocarbamate derivatives of 9,10-anthracenedione was evaluated in vitro on cancer cells of the human lung (A549), prostate (PC3), colon (HT29) and human breast (MCF7) using the sulforhodamine B (SRB) cell viability assay. Among these compounds, 9,10-dioxo-9,10-dihydroanthracen-1-yl pyrrolidin-1-carbodithioate and 9,10-dioxo-9,10-dihydroanthracen-2-yl pyrrolidin-1-carbodithioate were identified as the most potent anticancer agents with cytotoxic activity against the MCF-7 human breast cell line with GI(50) values of 1.40 M and 1.52 M, whereas the GI(50) value for the reference anticancer drug mitoxantrone was 3.93 M. Thus, anticancer activity predicted by PASS with a probability Pa > 30% was confirmed by the experiment. Relatively small Pa values estimated by PASS indicated the novelty of the considered derivatives comparing to the compounds from the PASS training set.
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Keywords
Chemistry, Computer science, Environmental sciences & ecology, Mathematical & computational biology, Toxicology, Anticancer activity, Cell line cytotoxicity predictor, computer-aided prediction, Dithiocarbamates of 9, 10-anthracenedione, PASS, PharmaExpert, Derivatives, Chemistry
Citation
Stasevych, M. vd. (2017). ''Computer-aided prediction and cytotoxicity evaluation of dithiocarbamates of 9,10-anthracenedione as new anticancer agents''. SAR and QSAR in Environmental Research, 28(5), 355-366.