Publication:
Esmolot pretreatment reduces the frequency and severity of pain on injection of rocuronium

dc.contributor.buuauthorYavaşçaoğlu, Belgin
dc.contributor.buuauthorKaya, Fatma Nur
dc.contributor.buuauthorÖzcan, Berin
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentAnesteziyoloji Ana Bilim Dalı
dc.contributor.researcheridAAG-9356-2021
dc.contributor.researcheridAAI-7914-2021
dc.contributor.researcheridAAI-8213-2021
dc.contributor.scopusid6602742300
dc.contributor.scopusid7003619647
dc.contributor.scopusid6603825848
dc.date.accessioned2022-09-16T05:40:50Z
dc.date.available2022-09-16T05:40:50Z
dc.date.issued2007-09
dc.description.abstractObjective: To determine the effect of esmolol on the frequency and severity of pain and withdrawal reactions after injection of rocuronium and to compare it with lidocaine and placebo. Design: Prospective, randomized, double-blind, placebo-controlled study. Setting: Single university hospital. Patients: 120 ASA physical status I and 11 patients undergoing general anesthesia for elective surgery. Interventions: Patients were randomized to receive esmolol (0.5 mg/kg), lidocaine (0.5 mg/kg), or placebo, followed by a subparalyzing dose of rocuronium. After induction of anesthesia with propofol and fentanyl, an intubating dose of rocuronium 0.6 mg/kg was given. Measurements: Patients were observed after injection of rocuronium 0.05 mg/kg, then immediately asked if they had pain in the arm. The response was assessed; discomfort, pain, and withdrawal of the hand were recorded and graded using a 4-point scale (none, mild, moderate, or severe). After the intubating dose of rocuronium, withdrawal reactions were scored as follows: (a) no pain response, (b) pain limited to the wrist, (c) pain limited to the elbow/shoulder, or (d) generalized pain response. Results: 31 patients (77.5%) in the esmolol group, 32 (80%) in the lidocaine group, and 15 (37.5%) in the placebo group reported no pain (both groups vs placebo, P < 0.001). Moderate pain was seen in only one patient receiving lidocaine, in 6 placebo patients, but in none in the esmolol group (esmolol vs placebo, P < 0.05). Severe pain was felt by 8 patients receiving placebo, but by none receiving esmolol or lidocaine (P < 0.01). Frequency of withdrawal response after rocuronium was 2.5%, 17.5%, and 40% in the esmolol, lidocaine, and placebo groups, respectively (esmolol group vs placebo, P < 0.001; lidocame group vs placebo, P < 0.05). Conclusion: Esmolol, like lidocame, reduces the frequency of pain and withdrawal reaction associated with rocuronium injection.
dc.identifier.citationYavaşçaoğlu, B. vd. (2007). "Esmolot pretreatment reduces the frequency and severity of pain on injection of rocuronium". Journal of Clinical Anesthesia, 19(6), 413-417.
dc.identifier.endpage417
dc.identifier.issn0952-8180
dc.identifier.issn1873-4529
dc.identifier.issue6
dc.identifier.pubmed17967668
dc.identifier.scopus2-s2.0-35448965657
dc.identifier.startpage413
dc.identifier.urihttps://doi.org/10.1016/j.jclinane.2007.02.011
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0952818007001729
dc.identifier.urihttp://hdl.handle.net/11452/28765
dc.identifier.volume19
dc.identifier.wos000250817600003
dc.indexed.scopusScopus
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherElsevier Science
dc.relation.journalJournal of Clinical Anesthesia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectEsmolol
dc.subjectInjection pain
dc.subjectLidocaine
dc.subjectRocuronium
dc.subjectSpomtaneous movements
dc.subjectLidocaine
dc.subjectPrevention
dc.subjectVecuronium
dc.subjectAnesthesia
dc.subjectPropofol
dc.subjectBlockade
dc.subjectFentanyl
dc.subjectBromide
dc.subjectAnesthesiology
dc.subject.emtreeAnesthesia induction
dc.subject.emtreeEsmolol
dc.subject.emtreeAbsence of side effects
dc.subject.emtreeAdult
dc.subject.emtreeAged
dc.subject.emtreeAnalgesia
dc.subject.emtreeAnalgesic activity
dc.subject.emtreeFentanyl
dc.subject.emtreeLidocaine
dc.subject.emtreePlacebo
dc.subject.emtreePropofol
dc.subject.emtreeRocuronium
dc.subject.emtreeArticle
dc.subject.emtreeDouble blind procedure
dc.subject.emtreeRandomized controlled trial
dc.subject.emtreeClinical trial
dc.subject.emtreeControlled clinical trial
dc.subject.emtreeControlled study
dc.subject.emtreeHuman
dc.subject.emtreeEdema
dc.subject.emtreeElective surgery
dc.subject.emtreeFemale
dc.subject.emtreeGeneral anesthesia
dc.subject.emtreeMajor clinical study
dc.subject.emtreeInjection
dc.subject.emtreeIntubation
dc.subject.emtreeMale
dc.subject.emtreeUniversity hospital
dc.subject.emtreeMuscle weakness
dc.subject.emtreePain
dc.subject.emtreePain assessment
dc.subject.emtreePriority journal
dc.subject.emtreeProspective study
dc.subject.emtreeSurgical patient
dc.subject.emtreeTreatment outcome
dc.subject.emtreeVein disease
dc.subject.meshInjections
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshAndrostanols
dc.subject.meshDouble-blind method
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshNeuromuscular nondepolarizing agents
dc.subject.meshMiddle aged
dc.subject.meshPain
dc.subject.meshPropanolamines
dc.subject.meshProspective studies
dc.subject.scopusPropofol; Rocuronium; Lidocaine
dc.subject.wosAnesthesiology
dc.titleEsmolot pretreatment reduces the frequency and severity of pain on injection of rocuronium
dc.typeArticle
dc.wos.quartileQ3
dc.wos.quartileQ3
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Anesteziyoloji Ana Bilim Dalı
local.indexed.atPubMed
local.indexed.atWOS
local.indexed.atScopus

Files

License bundle

Now showing 1 - 1 of 1
Placeholder
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description: