Publication: Synthesis of new anthraquinone compounds and evaluation of their considerable xanthine oxidase inhibitory activities
Date
Authors
Authors
Parladı, Ufuk
Yılmaz, Ülkü
Noma, Samir Abbas Ali
Ateş, Burhan
Küçükbay, Hasan
Advisor
Language
Type
Publisher:
Arkat Usa Inc
Journal Title
Journal ISSN
Volume Title
Abstract
A series of anthraquinone derivatives (1-11) was prepared using alkyl halides, quinizarin, and danthron. The structural analysis of new compounds was carried out by 1H, 13C NMR, IR, and UV-Vis spectroscopic techniques. Xanthine oxidase inhibitory activities of compounds were measured using allopurinol as a standard. Inhibition abilities were identified by measuring the uric acid formation at 294 nm at 37 degrees C. According to the IC50 values of the compounds, it was observed that all the compounds in the group had higher inhibition values than allopurinol.
Description
Source:
Keywords:
Keywords
Uric-acid, Derivatives, Quinizarin, Dyes, Sensitizer, Anthraquinone derivative, Quinizarin, Danthron, Xanthine oxidase, Inhibition, Chemistry