Publication:
Rituximab as a new therapeutic option in granulomatosis with polyangiitis: A report of two cases

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dc.contributor.authorKamalı, Sevil
dc.contributor.buuauthorDalkılıç, Ediz
dc.contributor.buuauthorAlkış, Nihan
dc.contributor.departmentİç Hastalıkları Ana Bilim Dalı
dc.contributor.departmentRomatoloji Bölümü
dc.contributor.scopusid6506739457
dc.contributor.scopusid26533912000
dc.date.accessioned2022-04-08T06:51:07Z
dc.date.available2022-04-08T06:51:07Z
dc.date.issued2012-07
dc.description.abstractFindings of several reports suggest that rituximab, a chimeric monoclonal anti-CD20 antibody causing B-lymphocyte depletion, might represent a treatment option for people with granulomatosis with polyangiitis (GPA) (former Wegener's granulomatosis). This study presents the results of rituximab treatment in two patients with treatment-refractory GPA. First patient received rituximab for a granulomatous posterior orbital mass lesion, and eye symptoms were resolved after three courses of treatment. The second patient had eye and paranasal sinus involvement and benefited from two courses of rituximab treatment, with significant clinical improvement. Rituximab may represent an effective novel treatment for remission induction in GPA.
dc.identifier.citationDalkılıç, E. vd. (2012). "Rituximab as a new therapeutic option in granulomatosis with polyangiitis: A report of two cases". Modern Rheumatology, 22(3), 463-466.
dc.identifier.endpage466
dc.identifier.issn1439-7595
dc.identifier.issn1439-7609
dc.identifier.issue3
dc.identifier.pubmed21847703
dc.identifier.scopus2-s2.0-84865388618
dc.identifier.startpage463
dc.identifier.urihttps://doi.org/10.1007/s10165-011-0507-7
dc.identifier.urihttps://www.tandfonline.com/doi/abs/10.3109/s10165-011-0507-7
dc.identifier.urihttp://hdl.handle.net/11452/25660
dc.identifier.volume22
dc.identifier.wos000305275300019
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherTaylor & Francis
dc.relation.collaborationYurt içi
dc.relation.collaborationSanayi
dc.relation.journalModern Rheumatology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectRheumatology
dc.subjectRituximab
dc.subjectGranulomatosis with polyangiitis
dc.subjectOcular involvement
dc.subjectWegeners-granulomatosis
dc.subjectVasculitis
dc.subjectCyclophosphamide
dc.subjectMethotrexate
dc.subjectEfficacy
dc.subjectTrial
dc.subject.emtreeAzathioprine
dc.subject.emtreeCyclophosphamide
dc.subject.emtreeMethotrexate
dc.subject.emtreeMethylprednisolone
dc.subject.emtreeNeutrophil cytoplasmic antibody
dc.subject.emtreePrednisolone
dc.subject.emtreeRituximab
dc.subject.emtreeAdult
dc.subject.emtreeArticle
dc.subject.emtreeClinical article
dc.subject.emtreeComputer assisted tomography
dc.subject.emtreeEpiscleritis
dc.subject.emtreeEye redness
dc.subject.emtreeFeet gangrenous lesion
dc.subject.emtreeFever
dc.subject.emtreeFoot amputation
dc.subject.emtreeFoot disease
dc.subject.emtreeHeadache
dc.subject.emtreeHuman
dc.subject.emtreeMalaise
dc.subject.emtreeMale
dc.subject.emtreeNose crusting
dc.subject.emtreeNose disease
dc.subject.emtreeNuclear magnetic resonance imaging
dc.subject.emtreePriority journal
dc.subject.emtreeSinusitis
dc.subject.emtreeWegener granulomatosis
dc.subject.meshAdult
dc.subject.meshAntibodies, antineutrophil cytoplasmic
dc.subject.meshAntibodies, monoclonal, murine-derived
dc.subject.meshHumans
dc.subject.meshImmunologic factors
dc.subject.meshMale
dc.subject.meshTreatment outcome
dc.subject.meshWegener granulomatosis
dc.subject.scopusWegener Granulomatosis; ANCA Associated Vasculitis; Antineutrophil Cytoplasmic Antibodies
dc.subject.wosRheumatology
dc.titleRituximab as a new therapeutic option in granulomatosis with polyangiitis: A report of two cases
dc.typeArticle
dc.wos.quartileQ3
dspace.entity.typePublication
local.contributor.departmentİç Hastalıkları Ana Bilim Dalı/Romatoloji Bölümü
local.indexed.atScopus
local.indexed.atWOS

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