Publication: Anti-inflammatory efficiency of levobupivacaine in an experimental colitis model
dc.contributor.buuauthor | Duman, Uğur | |
dc.contributor.buuauthor | Yılmazlar, Aysun | |
dc.contributor.buuauthor | Öztürk, Ersin | |
dc.contributor.buuauthor | Aker, Sibel | |
dc.contributor.buuauthor | Sarandöl, Emre | |
dc.contributor.buuauthor | Yılmazlar, Tuncay | |
dc.contributor.department | Tıp Fakültesi | |
dc.contributor.department | Tıp Fakültesi | |
dc.contributor.department | Tıp Fakültesi | |
dc.contributor.department | Tıp Fakültesi | |
dc.contributor.department | Tıbbi Patoloji Ana Bilim Dalı | |
dc.contributor.department | Anesteziyoloji ve Reanimasyon Ana Bilim Dalı | |
dc.contributor.department | Genel Cerrahi Ana Bilim Dalı | |
dc.contributor.department | Tıbbi Biyokimya Ana Bilim Dalı | |
dc.contributor.orcid | 0000-0002-2593-7196 | tr_TR |
dc.contributor.orcid | 0000-0002-4946-555X | tr_TR |
dc.contributor.researcherid | ABE-1716-2020 | tr_TR |
dc.contributor.researcherid | H-5770-2018 | tr_TR |
dc.contributor.scopusid | 36971700700 | tr_TR |
dc.contributor.scopusid | 55899579900 | tr_TR |
dc.contributor.scopusid | 35070171400 | tr_TR |
dc.contributor.scopusid | 12795285000 | tr_TR |
dc.contributor.scopusid | 55943324800 | tr_TR |
dc.contributor.scopusid | 6701800362 | tr_TR |
dc.date.accessioned | 2022-07-07T10:59:07Z | |
dc.date.available | 2022-07-07T10:59:07Z | |
dc.date.issued | 2010-05-28 | |
dc.description.abstract | AIM: To investigate the efficiency of levobupivacaine in treating experimentally induced colitis in rats. METHODS: Colitis was induced by trinitrobenzene sulfonic acid and ethanol in 30 rats under general anesthesia, and 10 rats were used as a sham group. Subsequent to induction of colitis, rats were divided into three groups; budesonide group received 0.1 mg/kg budesonide, levobupivacaine group received 10 mg/kg levobupivacaine and saline group received 1 mL saline solution via rectal route for 7 d. In the sham group, only routine rectal catheterization was performed without use of any material. At the end of 7 d, laparotomy and total colectomy were performed for histopathological examination in all rats and blood samples were drawn for measurement of tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 following cardiac puncture. Macroscopic and microscopic evaluations of the specimens were performed by a pathologist blinded to group assignment of the rats. RESULTS: Weight loss (P = 0.016) and macroscopic examination scores (P = 0.001) were significantly higher in saline group than others. Histopathological scoring was comparable between all colitis groups (P = 0.350). There was no significant difference in TNF-alpha levels and IL-6 levels (P = 0.150). CONCLUSION: The significant improvement in macroscopic scores suggests that levobupivacaine may have topical anti-inflammatory effects in an experimental colitis model; however, this finding was not supported by microscopic findings. | en_US |
dc.identifier.citation | Duman, U. vd. (2010). "Anti-inflammatory efficiency of levobupivacaine in an experimental colitis model". World Journal of Gastroenterology, 16(20), 2537-2541. | en_US |
dc.identifier.endpage | 2541 | tr_TR |
dc.identifier.issn | 1007-9327 | |
dc.identifier.issn | 2219-2840 | |
dc.identifier.issue | 20 | tr_TR |
dc.identifier.pubmed | 20503454 | tr_TR |
dc.identifier.scopus | 2-s2.0-77953260704 | tr_TR |
dc.identifier.startpage | 2537 | tr_TR |
dc.identifier.uri | https://doi.org/10.3748/wjg.v16.i20.2537 | |
dc.identifier.uri | https://www.wjgnet.com/1007-9327/full/v16/i20/2537.htm | |
dc.identifier.uri | http://hdl.handle.net/11452/27792 | |
dc.identifier.volume | 16 | tr_TR |
dc.identifier.wos | 000278196800012 | |
dc.indexed.pubmed | PubMed | en_US |
dc.indexed.wos | SCIE | en_US |
dc.language.iso | en | en_US |
dc.publisher | Baishideng Publishing Group | en_US |
dc.relation.journal | World Journal of Gastroenterology | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Trinitrobenzene sulfonic acid | en_US |
dc.subject | Colitis | en_US |
dc.subject | Levobupivacaine | en_US |
dc.subject | Budesonide | en_US |
dc.subject | Inflammatory-bowel-disease | en_US |
dc.subject | Ulcerative-colitis | en_US |
dc.subject | Local-anesthetics | en_US |
dc.subject | Lidocaine | en_US |
dc.subject | Ropivacaine | en_US |
dc.subject | Proctitis | en_US |
dc.subject | Therapy | en_US |
dc.subject | Cells | en_US |
dc.subject | Gastroenterology & hepatology | en_US |
dc.subject.emtree | Alcohol | en_US |
dc.subject.emtree | Budesonide | en_US |
dc.subject.emtree | Interleukin 6 | en_US |
dc.subject.emtree | Levobupivacaine | en_US |
dc.subject.emtree | Sodium chloride | en_US |
dc.subject.emtree | Trinitrobenzenesulfonic acid | en_US |
dc.subject.emtree | Tumor necrosis factor alpha | en_US |
dc.subject.emtree | Animal cell | en_US |
dc.subject.emtree | Animal experiment | en_US |
dc.subject.emtree | Animal model | en_US |
dc.subject.emtree | Animal tissue | en_US |
dc.subject.emtree | Antiinflammatory activity | en_US |
dc.subject.emtree | Article | en_US |
dc.subject.emtree | Blood sampling | en_US |
dc.subject.emtree | Catheterization | en_US |
dc.subject.emtree | Colitis | en_US |
dc.subject.emtree | Colon resection | en_US |
dc.subject.emtree | Controlled study | en_US |
dc.subject.emtree | Drug efficacy | en_US |
dc.subject.emtree | Enteritis | en_US |
dc.subject.emtree | Histopathology | en_US |
dc.subject.emtree | Laparotomy | en_US |
dc.subject.emtree | Male | en_US |
dc.subject.emtree | Nonhuman | en_US |
dc.subject.emtree | Rat | en_US |
dc.subject.emtree | Single drug dose | en_US |
dc.subject.emtree | Weight reduction | en_US |
dc.subject.scopus | Lidocaine; Postoperative Nausea and Vomiting; Intravenous | en_US |
dc.subject.wos | Gastroenterology & hepatology | en_US |
dc.title | Anti-inflammatory efficiency of levobupivacaine in an experimental colitis model | en_US |
dc.type | Article | |
dc.wos.quartile | Q2 | en_US |
dspace.entity.type | Publication | |
local.contributor.department | Tıp Fakültesi/Genel Cerrahi Ana Bilim Dalı | tr_TR |
local.contributor.department | Tıp Fakültesi/Anesteziyoloji ve Reanimasyon Ana Bilim Dalı | tr_TR |
local.contributor.department | Tıp Fakültesi/Tıbbi Patoloji Ana Bilim Dalı | tr_TR |
local.contributor.department | Tıp Fakültesi/Tıbbi Biyokimya Ana Bilim Dalı | tr_TR |
local.indexed.at | Scopus |