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A rare cause of epilepsy: Ulegyria revisited in a series of 10 patients

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dc.contributor.authorDemir, Aylin Bican
dc.contributor.authorEser, Pınar
dc.contributor.authorBekar, Ahmet
dc.contributor.authorHakyemez, Bahattin
dc.contributor.authorBora, İbrahim
dc.contributor.buuauthorBİCAN DEMİR, AYLİN
dc.contributor.buuauthorEser, Pınar
dc.contributor.buuauthorBEKAR, AHMET
dc.contributor.buuauthorHAKYEMEZ, BAHATTİN
dc.contributor.buuauthorBORA, İBRAHİM HAKKI
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Nöroloji Anabilim Dalı/Epilepsi Merkezi.
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Beyin Cerrahi Anabilim Dalı.
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Radyoloji Anabilim Dalı.
dc.contributor.orcid0000-0001-6739-8605
dc.contributor.orcid0000-0003-0132-9927
dc.contributor.orcid0000-0002-3425-0740
dc.contributor.researcheridABX-9081-2022
dc.contributor.researcheridAAI-2073-2021
dc.contributor.researcheridV-7170-2017
dc.contributor.researcheridAAI-2318-2021
dc.contributor.researcheridENI-7759-2022
dc.date.accessioned2024-06-10T10:35:11Z
dc.date.available2024-06-10T10:35:11Z
dc.date.issued2021-09-17
dc.description.abstractIntroduction. Ulegyria results from perinatal hypoxic-ischemic brain injury in term infants. The specific mushroom-shaped configuration of ulegyria results from small atrophic circumvolutions at the bottom of a sulcus underlying an intact gyral apex. Clinically, ulegyria is generally associated with epilepsy. Here, we aimed to delineate the characteristics of patients with ulegyria and the epileptic seizures they experience. Material and methods. Medical records including radiology and pathology reports, video-electroencephalographic (EEG) analysis, operative notes, hospital progress and outpatient clinic notes were reviewed retrospectively in a total of 10 ulegyria patients. Results. Patients ages ranged between 24 and 58 years (mean, 32 +/- 9.8 years). Past medical history was confirmed for neonatal asphyxia in 2 (20%). Neurological examination was remarkable for spastic hemiparesis in 1 (10%) patient with perisylvian ulegyria and for visual field deficits in 2 patients (20%) with occipital ulegyria. Ulegyria most commonly involved the temporoparietal region (n = 5, 50%) followed by the perisylvian area (n = 2, 20%). Except the one with bilateral perisylvian ulegyria, all patients had unilateral lesions (n = 9, 90%). Hippocampal sclerosis accompanied ulegyria in 2 patients (20%). All patients experienced epileptic seizures. Mean age at seizure onset was 8.8 +/- 5.4 years (range, 2-20 years). Interictal scalp EEG and EEG-video monitoring records demonstrated temporoparietal and frontotemporal activities in 5 (50%) and 2 (20%) patients, respectively. The seizures were successfully controlled by antiepileptic medication in 8 patients (n = 8, 80%). The remaining 2 patients (%20) with concomitant hippocampal sclerosis required microsurgical resection of the seizure foci due to medically resistant seizures. Discussion. Ulegyria is easily recognized with its unique magnetic resonance imaging characteristics and clinical presentation in the majority of cases. It is highly associated with either medically resistant or medically controllable epileptic seizures. The treatment strategy depends on the age at onset and extends of the lesion that has a significant impact on the severity of the clinical picture.
dc.identifier.doi10.1177/15500594211043308
dc.identifier.eissn2169-5202
dc.identifier.endpage159
dc.identifier.issn1550-0594
dc.identifier.issue2
dc.identifier.startpage153
dc.identifier.urihttps://doi.org/10.1177/15500594211043308
dc.identifier.urihttps://journals.sagepub.com/doi/10.1177/15500594211043308
dc.identifier.urihttps://hdl.handle.net/11452/41927
dc.identifier.volume53
dc.identifier.wos000697044400001
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherSage Publications
dc.relation.journalClinical EEG and Neuroscience
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectHypoxic-ischemic encephalopathy
dc.subjectI-123 iodoamphetamine
dc.subjectImaging findings
dc.subjectBrain
dc.subjectEpilepsy
dc.subjectHypoxic-ischemic brain injury
dc.subjectEpilepsy surgery
dc.subjectUlegyria
dc.subjectNeurosciences & neurology
dc.subjectPsychiatry
dc.subjectPsychology
dc.titleA rare cause of epilepsy: Ulegyria revisited in a series of 10 patients
dc.typeArticle
dspace.entity.typePublication
relation.isAuthorOfPublication8b72317c-2cda-4511-bba9-51f797dadec4
relation.isAuthorOfPublicatione929e321-8731-462f-8655-65e237321fef
relation.isAuthorOfPublication9ad8c0f1-5154-4a82-b029-77c58cb35066
relation.isAuthorOfPublication7674bbf4-9c63-42a4-b1e0-09ecdcb8f05a
relation.isAuthorOfPublication.latestForDiscovery8b72317c-2cda-4511-bba9-51f797dadec4

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