Publication:
Serum concentrations of human angiopoietin-like protein 3 in patients with nonalcoholic fatty liver disease: Association with insulin resistance

dc.contributor.authorYılmaz, Yusuf Cem
dc.contributor.authorAtuğ, Özlen
dc.contributor.buuauthorUlukaya, Engin
dc.contributor.buuauthorDolar, Enver
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentBiyokimya Ana Bilim Dalı
dc.contributor.departmentGastroenteroloji Ana Bilim Dalı
dc.contributor.researcheridK-5792-2018
dc.contributor.researcheridAAG-9177-2021
dc.contributor.scopusid6602927353
dc.contributor.scopusid6602075084
dc.date.accessioned2021-12-02T09:20:35Z
dc.date.available2021-12-02T09:20:35Z
dc.date.issued2009-11
dc.description.abstractObjective Insulin resistance is considered a key feature of nonalcoholic fatty liver disease (NAFLD). In this setting, experimental studies have suggested a potential role of angiopoietin-like (ANGPTL) proteins in the pathogenesis of hepatic steatosis and the metabolic syndrome. In this study, we sought to investigate the plasma levels of ANGPTL protein 3 (ANGPTL3) - a liver-derived protein that modulates plasma triglyceride clearance - in patients with definite nonalcoholic steatohepatitis (NASH, n = 40), borderline NASH (n = 8), simple fatty liver (n = 9), and healthy controls without evidence of liver disease (n = 14). Methods Levels of ANGPTL3 were measured by enzyme-linked immunosorbent assay and compared in the four study groups. Moreover, concentrations of ANGPTL3 were assessed in relation to the general characteristics of the study participants and the results of liver biopsy. Results Levels of ANGPTL3 were significantly higher in patients with definite NASH (389 +/- 110 ng/ml, P < 0.05) and borderline NASH (433 +/- 70 ng/ml, P < 0.05) compared with controls (291 +/- 78 ng/ml). No significant differences were found in patients with simple fatty liver (321 +/- 119 ng/ml) as compared with controls. In correlation analyses of the entire study cohort, ANGPTL3 was significantly and positively associated with homeostatic model assessment for insulin resistance (r = 0.28, P < 0.05) but not with histological staging and pathological characteristics of NAFLD. Conclusion Although subject to future confirmation, our data suggest that ANGPTL3 levels are elevated in the more severe forms of NAFLD and could be associated with insulin resistance in this setting.
dc.identifier.citationYılmaz, Y. vd. (2009). "Serum concentrations of human angiopoietin-like protein 3 in patients with nonalcoholic fatty liver disease: Association with insulin resistance". European Journal of Gastroenterology and Hepatology, 21(11), 1247-1251.
dc.identifier.endpage1251
dc.identifier.issn0954-691X
dc.identifier.issue11
dc.identifier.pubmed19474742
dc.identifier.scopus2-s2.0-70350142150
dc.identifier.startpage1247
dc.identifier.urihttps://doi.org/10.1097/MEG.0b013e32832b77ae
dc.identifier.urihttps://journals.lww.com/eurojgh/Fulltext/2009/11000/Serum_concentrations_of_human_angiopoietin_like.3.aspx
dc.identifier.urihttp://hdl.handle.net/11452/22957
dc.identifier.volume21
dc.identifier.wos000271301100003
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherLippincott Williams & Wilkins
dc.relation.collaborationYurt içi
dc.relation.journalEuropean Journal of Gastroenterology and Hepatology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAngiopoietin-like protein 3
dc.subjectBiomarkers
dc.subjectLiver injury
dc.subjectNonalcoholic fatty liver disease
dc.subjectMetabolic syndrome
dc.subjectAngptl3
dc.subjectExpression
dc.subjectSecretion
dc.subjectGastroenterology & hepatology
dc.subject.emtreeAlanine aminotransferase
dc.subject.emtreeAngiopoietin
dc.subject.emtreeAngiopoietin like protein 3
dc.subject.emtreeAspartate aminotransferase blood level
dc.subject.emtreeBiological marker
dc.subject.emtreeInsulin
dc.subject.emtreeLiver protein
dc.subject.emtreeRegulator protein
dc.subject.emtreeTriacylglycerol
dc.subject.emtreeUnclassified drug
dc.subject.emtreeAdult
dc.subject.emtreeAlanine aminotransferase blood level
dc.subject.emtreeArticle
dc.subject.emtreeAspartate aminotransferase blood level
dc.subject.emtreeControlled study
dc.subject.emtreeCorrelation analysis
dc.subject.emtreeDisease severity
dc.subject.emtreeEchography
dc.subject.emtreeEnzyme linked immunosorbent assay
dc.subject.emtreeFemale
dc.subject.emtreeHuman
dc.subject.emtreeHuman tissue
dc.subject.emtreeInsulin resistance
dc.subject.emtreeLiver biopsy
dc.subject.emtreeMajor clinical study
dc.subject.emtreeMale
dc.subject.emtreeNonalcoholic fatty liver
dc.subject.emtreePathogenesis
dc.subject.emtreePriority journal
dc.subject.emtreeProtein blood level
dc.subject.emtreeProtein function
dc.subject.emtreeRoc curve
dc.subject.emtreeSensitivity and specificity
dc.subject.meshAdult
dc.subject.meshAngiopoietins
dc.subject.meshBiological markers
dc.subject.meshBiopsy
dc.subject.meshFatty liver
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshInsulin resistance
dc.subject.meshLiver
dc.subject.meshMale
dc.subject.meshMiddle aged
dc.subject.scopusAngiopoietin-like Proteins; Lipoprotein Lipase; Human ANGPTL2 Protein
dc.subject.wosGastroenterology & hepatology
dc.titleSerum concentrations of human angiopoietin-like protein 3 in patients with nonalcoholic fatty liver disease: Association with insulin resistance
dc.typeArticle
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Biyokimya Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Gastroenteroloji Ana Bilim Dalı
local.indexed.atPubMed
local.indexed.atWOS

Files