Publication: Coexistence of TERT C228T mutation and MALAT1 dysregulation in primary glioblastoma: new prognostic and therapeutic targets
dc.contributor.author | Ak Aksoy, Seçil | |
dc.contributor.author | Mutlu, Melis | |
dc.contributor.author | Tunca, Berrin | |
dc.contributor.author | Kocaeli, Hasan | |
dc.contributor.author | Taşkapılıoğlu, Mevlüt Özgür | |
dc.contributor.author | Bekar, Ahmet | |
dc.contributor.author | Tekin, Çağla | |
dc.contributor.author | Arğadal, Ömer Gökay | |
dc.contributor.author | Civan, Muhammet Nafi | |
dc.contributor.author | Kaya, İsmail Seçkin | |
dc.contributor.author | Ocak, Pınar Eser | |
dc.contributor.author | Tolunay, Şahsine | |
dc.contributor.buuauthor | AKSOY, SEÇİL | |
dc.contributor.buuauthor | Mutlu, Melis | |
dc.contributor.buuauthor | TUNCA, BERRİN | |
dc.contributor.buuauthor | KOCAELİ, HASAN | |
dc.contributor.buuauthor | TAŞKAPILIOĞLU, MEVLÜT ÖZGÜR | |
dc.contributor.buuauthor | BEKAR, AHMET | |
dc.contributor.buuauthor | Tekin, Çağla | |
dc.contributor.buuauthor | ARGADAL, ÖMER GÖKAY | |
dc.contributor.buuauthor | Civan, Muhammet Nafi | |
dc.contributor.buuauthor | KAYA, İSMAİL SEÇKİN | |
dc.contributor.buuauthor | OCAK, PINAR | |
dc.contributor.buuauthor | TOLUNAY, ŞAHSİNE | |
dc.contributor.department | Bursa Uludağ Üniversitesi/İnegöl Meslek Yüksekokulu. | |
dc.contributor.department | Bursa Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyoloji Anabilim Dalı. | |
dc.contributor.department | Bursa Uludağ Üniversitesi/Tıp Fakültesi/Beyin Cerrahi Anabilim Dalı. | |
dc.contributor.department | Bursa Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı. | |
dc.contributor.orcid | 0000-0002-1619-6680 | |
dc.contributor.orcid | 0000-0001-5472-9065 | |
dc.contributor.orcid | 0000-0003-0132-9927 | |
dc.contributor.orcid | 0000-0002-5126-1548 | |
dc.contributor.researcherid | ADM-8457-2022 | |
dc.contributor.researcherid | ABX-9081-2022 | |
dc.contributor.researcherid | AAI-2073-2021 | |
dc.contributor.researcherid | FPB-0403-2022 | |
dc.contributor.researcherid | ABI-6078-2020 | |
dc.contributor.researcherid | FDK-3229-2022 | |
dc.contributor.researcherid | AAW-5254-2020 | |
dc.contributor.researcherid | GDC-6329-2022 | |
dc.contributor.researcherid | CCA-2925-2022 | |
dc.contributor.researcherid | HKP-0793-2023 | |
dc.contributor.researcherid | ILC-4543-2023 | |
dc.contributor.researcherid | AAI-1612-2021 | |
dc.date.accessioned | 2024-06-26T13:22:26Z | |
dc.date.available | 2024-06-26T13:22:26Z | |
dc.date.issued | 2021-06-21 | |
dc.description.abstract | Objective: This study was designed to conduct molecular classification based on IDH1/2, TERT, ATRX, and DAXX changes in pediatric and adult primary glioblastoma (GB) and to analyze the potential interaction of LncRNA MALAT1 in the determined homogeneous subgroups. Methods: We analyzed the expression profiles of ATRX/DAXX and MALAT1 using the qRT-PCR method and IDH and TERT mutation status using DNA sequencing analysis in 85 primary pediatric and adult GB patients. Results: IDH1 mutation was observed in 5 (5.88%) and TERT mutation in 65 (76.47%) primary pediatric and adult GB patients. ATRX and DAXX were detected in 18 (21.18%) and 7 (8.24%) patients. TERT mutation and loss of ATRX/DAXX were associated with short overall survival (p < 0.001, p < 0.001, respectively). Patients carrying especially TERT C228T mutation had worse prognosis (p < 0.001). Six subgroups were obtained from the genetic analysis. Among the subgroups, MALAT1 was highly expressed in group A that had a single TERT mutation as compared to that in groups D and E (p = 0.001 and p < 0.001, respectively); further, high MALAT1 expression was associated with worse prognosis in patients with C228T mutation (p < 0.001). Conclusions: Our findings highlight that the presence of TERT C228T mutation and expression of MALAT1 can be used as primary targets during the follow-up of primary GB patients and in the development of new treatment strategies. | |
dc.identifier.doi | 10.1080/01616412.2021.1948738 | |
dc.identifier.eissn | 1743-1328 | |
dc.identifier.endpage | 925 | |
dc.identifier.issn | 0161-6412 | |
dc.identifier.issue | 11 | |
dc.identifier.startpage | 916 | |
dc.identifier.uri | https://doi.org/10.1080/01616412.2021.1948738 | |
dc.identifier.uri | https://www.tandfonline.com/doi/full/10.1080/01616412.2021.1948738 | |
dc.identifier.uri | https://hdl.handle.net/11452/42463 | |
dc.identifier.volume | 43 | |
dc.identifier.wos | 000669136900001 | |
dc.indexed.wos | WOS.SCI | |
dc.language.iso | en | |
dc.publisher | Taylor & Francis | |
dc.relation.bap | OUAP(T)-2019/3 | |
dc.relation.journal | Neurological Research | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | |
dc.relation.tubitak | 218S891 | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | Long noncoding RNA | |
dc.subject | Pediatric glioblastoma | |
dc.subject | Tumors | |
dc.subject | Temozolomide | |
dc.subject | Glioma | |
dc.subject | Cells | |
dc.subject | Atrx | |
dc.subject | Glioblastoma | |
dc.subject | IDH1 | |
dc.subject | 2 | |
dc.subject | Tert | |
dc.subject | MALAT1 | |
dc.subject | Prognosis | |
dc.subject | Neurosciences & neurology | |
dc.title | Coexistence of TERT C228T mutation and MALAT1 dysregulation in primary glioblastoma: new prognostic and therapeutic targets | |
dc.type | Article | |
dspace.entity.type | Publication | |
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