Publication:
Coexistence of TERT C228T mutation and MALAT1 dysregulation in primary glioblastoma: new prognostic and therapeutic targets

dc.contributor.authorAk Aksoy, Seçil
dc.contributor.authorMutlu, Melis
dc.contributor.authorTunca, Berrin
dc.contributor.authorKocaeli, Hasan
dc.contributor.authorTaşkapılıoğlu, Mevlüt Özgür
dc.contributor.authorBekar, Ahmet
dc.contributor.authorTekin, Çağla
dc.contributor.authorArğadal, Ömer Gökay
dc.contributor.authorCivan, Muhammet Nafi
dc.contributor.authorKaya, İsmail Seçkin
dc.contributor.authorOcak, Pınar Eser
dc.contributor.authorTolunay, Şahsine
dc.contributor.buuauthorAKSOY, SEÇİL
dc.contributor.buuauthorMutlu, Melis
dc.contributor.buuauthorTUNCA, BERRİN
dc.contributor.buuauthorKOCAELİ, HASAN
dc.contributor.buuauthorTAŞKAPILIOĞLU, MEVLÜT ÖZGÜR
dc.contributor.buuauthorBEKAR, AHMET
dc.contributor.buuauthorTekin, Çağla
dc.contributor.buuauthorARGADAL, ÖMER GÖKAY
dc.contributor.buuauthorCivan, Muhammet Nafi
dc.contributor.buuauthorKAYA, İSMAİL SEÇKİN
dc.contributor.buuauthorOCAK, PINAR
dc.contributor.buuauthorTOLUNAY, ŞAHSİNE
dc.contributor.departmentBursa Uludağ Üniversitesi/İnegöl Meslek Yüksekokulu.
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyoloji Anabilim Dalı.
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Beyin Cerrahi Anabilim Dalı.
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.
dc.contributor.orcid0000-0002-1619-6680
dc.contributor.orcid0000-0001-5472-9065
dc.contributor.orcid0000-0003-0132-9927
dc.contributor.orcid0000-0002-5126-1548
dc.contributor.researcheridADM-8457-2022
dc.contributor.researcheridABX-9081-2022
dc.contributor.researcheridAAI-2073-2021
dc.contributor.researcheridFPB-0403-2022
dc.contributor.researcheridABI-6078-2020
dc.contributor.researcheridFDK-3229-2022
dc.contributor.researcheridAAW-5254-2020
dc.contributor.researcheridGDC-6329-2022
dc.contributor.researcheridCCA-2925-2022
dc.contributor.researcheridHKP-0793-2023
dc.contributor.researcheridILC-4543-2023
dc.contributor.researcheridAAI-1612-2021
dc.date.accessioned2024-06-26T13:22:26Z
dc.date.available2024-06-26T13:22:26Z
dc.date.issued2021-06-21
dc.description.abstractObjective: This study was designed to conduct molecular classification based on IDH1/2, TERT, ATRX, and DAXX changes in pediatric and adult primary glioblastoma (GB) and to analyze the potential interaction of LncRNA MALAT1 in the determined homogeneous subgroups. Methods: We analyzed the expression profiles of ATRX/DAXX and MALAT1 using the qRT-PCR method and IDH and TERT mutation status using DNA sequencing analysis in 85 primary pediatric and adult GB patients. Results: IDH1 mutation was observed in 5 (5.88%) and TERT mutation in 65 (76.47%) primary pediatric and adult GB patients. ATRX and DAXX were detected in 18 (21.18%) and 7 (8.24%) patients. TERT mutation and loss of ATRX/DAXX were associated with short overall survival (p < 0.001, p < 0.001, respectively). Patients carrying especially TERT C228T mutation had worse prognosis (p < 0.001). Six subgroups were obtained from the genetic analysis. Among the subgroups, MALAT1 was highly expressed in group A that had a single TERT mutation as compared to that in groups D and E (p = 0.001 and p < 0.001, respectively); further, high MALAT1 expression was associated with worse prognosis in patients with C228T mutation (p < 0.001). Conclusions: Our findings highlight that the presence of TERT C228T mutation and expression of MALAT1 can be used as primary targets during the follow-up of primary GB patients and in the development of new treatment strategies.
dc.identifier.doi10.1080/01616412.2021.1948738
dc.identifier.eissn1743-1328
dc.identifier.endpage925
dc.identifier.issn0161-6412
dc.identifier.issue11
dc.identifier.startpage916
dc.identifier.urihttps://doi.org/10.1080/01616412.2021.1948738
dc.identifier.urihttps://www.tandfonline.com/doi/full/10.1080/01616412.2021.1948738
dc.identifier.urihttps://hdl.handle.net/11452/42463
dc.identifier.volume43
dc.identifier.wos000669136900001
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherTaylor & Francis
dc.relation.bapOUAP(T)-2019/3
dc.relation.journalNeurological Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.relation.tubitak218S891
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectLong noncoding RNA
dc.subjectPediatric glioblastoma
dc.subjectTumors
dc.subjectTemozolomide
dc.subjectGlioma
dc.subjectCells
dc.subjectAtrx
dc.subjectGlioblastoma
dc.subjectIDH1
dc.subject2
dc.subjectTert
dc.subjectMALAT1
dc.subjectPrognosis
dc.subjectNeurosciences & neurology
dc.titleCoexistence of TERT C228T mutation and MALAT1 dysregulation in primary glioblastoma: new prognostic and therapeutic targets
dc.typeArticle
dspace.entity.typePublication
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relation.isAuthorOfPublication.latestForDiscovery8bdd2606-375e-4245-8bdc-c609f605bfd4

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