Yayın:
Investigation of the genotoxic effect in bone marrow of swiss albino mice exposed long-term to pyrimethamine

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dc.contributor.buuauthorTunca, Berrin
dc.contributor.buuauthorEgeli, U.
dc.contributor.buuauthorAydemir, Nilüfer Cinkılıç
dc.contributor.buuauthorCecener, Gülşah
dc.contributor.buuauthorBilaloğlu, Rahmi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentFen Edebiyat Fakültesi
dc.contributor.departmentMoleküler Biyoloji ve Genetik Ana Bilim Dalı
dc.contributor.departmentBiyoloji Bölümü
dc.contributor.orcid0000-0002-3595-6286
dc.contributor.orcid0000-0002-3820-424X
dc.contributor.orcid0000-0002-1619-6680
dc.contributor.researcheridAAH-5296-2021
dc.contributor.researcheridAAP-9988-2020
dc.contributor.researcheridABI-6078-2020
dc.contributor.scopusid6602965754
dc.contributor.scopusid6701760348
dc.contributor.scopusid26533892300
dc.contributor.scopusid6508156530
dc.contributor.scopusid6505804122
dc.date.accessioned2021-12-08T07:12:09Z
dc.date.available2021-12-08T07:12:09Z
dc.date.issued2002
dc.description.abstractIn the present study, we investigated the genotoxic effect of pyrimethamine, which is a drug used in the therapy of toxoplasmosis and malaria, in bone marrow cells of Swiss albino mice exposed to three doses (1, 4, 8 mg/kg) of this agent for eight months orally in vivo. We used a chromosome analysis and micronucleus test for evaluation of genotoxic effect. While a statistically significant change was not determined in numerical chromosome abnormalities, structural chromosome aberrations and micronuclei were increased in a dose-dependent manner by cytogenetic and statistical evaluations.
dc.identifier.citationTunca, B. vd. (2002). "Investigation of the genotoxic effect in bone marrow of swiss albino mice exposed long-term to pyrimethamine". Teratogenesis Carcinogenesis and Mutagenesıs, 22(6), 393-402.
dc.identifier.doi10.1002/tcm.10036
dc.identifier.endpage402
dc.identifier.issn0270-3211
dc.identifier.issue6
dc.identifier.pubmed12395401
dc.identifier.scopus2-s2.0-0036409361
dc.identifier.startpage393
dc.identifier.urihttps://doi.org/10.1002/tcm.10036
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/10.1002/tcm.10036
dc.identifier.urihttp://hdl.handle.net/11452/23069
dc.identifier.volume22
dc.identifier.wos000179021800001
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherWiley Liss
dc.relation.journalTeratogenesis Carcinogenesis and Mutagenesis
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBone marrow
dc.subjectChromosome aberrations
dc.subjectMicronucleus
dc.subjectPyrimethamine
dc.subjectSwiss albino mice
dc.subjectCommon fragile sites
dc.subjectIn-vivo mouse
dc.subjectFhit gene
dc.subjectChromosome-aberrations
dc.subjectlymphocyte-cultures
dc.subjectSpindle poisons
dc.subjectChl cells
dc.subjectExpression
dc.subjectInduction
dc.subjectCancer
dc.subjectOncology
dc.subjectGenetics & heredity
dc.subjectToxicology
dc.subject.emtreePyrimethamine
dc.subject.emtreeMutagenic agent
dc.subject.emtreeAntimalarial agent
dc.subject.emtreeAnimal experiment
dc.subject.emtreeBone marrow toxicity
dc.subject.emtreeNumerical chromosome aberration
dc.subject.emtreePyrimethamine
dc.subject.emtreeArticle
dc.subject.emtreeAnimal cell
dc.subject.emtreeAnimal model
dc.subject.emtreeBone marrow cell
dc.subject.emtreeCytogenetics drug exposure
dc.subject.emtreeMutagen testing
dc.subject.emtreeChromosome analysis
dc.subject.emtreeControlled study
dc.subject.emtreeDose response
dc.subject.emtreeDrug indication
dc.subject.emtreeFemale
dc.subject.emtreeMale
dc.subject.emtreeGenotoxicity
dc.subject.emtreeMalaria
dc.subject.emtreeMicronucleus
dc.subject.emtreeMouse
dc.subject.emtreeMouse strain
dc.subject.emtreeNonhuman
dc.subject.emtreePriority journal
dc.subject.emtreeStatistical significance
dc.subject.emtreeStructural chromosome aberration
dc.subject.emtreeToxoplasmosis
dc.subject.emtreeAnimal
dc.subject.emtreeBone marrow
dc.subject.emtreeChromosome
dc.subject.emtreeChromosome aberration
dc.subject.emtreeDrug effect
dc.subject.emtreeErythrocyte
dc.subject.emtreeMicronucleus test
dc.subject.emtreeTime
dc.subject.meshAntimalarials
dc.subject.meshChromosome aberrations
dc.subject.meshDose-response relationship
dc.subject.meshMutagenicity tests
dc.subject.meshTime factors
dc.subject.meshBone marrow
dc.subject.meshAnimals
dc.subject.meshDrug
dc.subject.meshErythrocytes
dc.subject.meshFemale
dc.subject.meshMale
dc.subject.meshMice
dc.subject.meshMicronucleus tests
dc.subject.meshMutagens
dc.subject.meshPyrimethamine
dc.subject.scopusHyperpigmentation; Vitamin B 12 Deficiency; Megaloblastic Anemia
dc.subject.wosOncology
dc.subject.wosGenetics & heredity
dc.subject.wosToxicology
dc.titleInvestigation of the genotoxic effect in bone marrow of swiss albino mice exposed long-term to pyrimethamine
dc.typeArticle
dc.wos.quartileQ3 ( Toxicology)
dc.wos.quartileQ4
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Moleküler Biyoloji ve Genetik Ana Bilim Dalı
local.contributor.departmentFen Edebiyat Fakültesi/Biyoloji Bölümü
local.indexed.atScopus
local.indexed.atWOS

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