Publication: Nephrotoxicity caused by colistin use in icu: A single centre experience
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Date
2023-10-13
Authors
Kaya, Pınar Küçükdemirci
Authors
Kılıç, İsa
Ayar, Yavuz
Ceylan, İlkay
Çalışkan, Gülbahar
Journal Title
Journal ISSN
Volume Title
Publisher
Bmc
Abstract
Background We aimed to determine the risk factors that may be associated with colistin-induced acute kidney injury (AKI) to promote the safer use of colistin in the treatment of nosocomial infections caused by multidrug-resistant Gram-negative bacteria in intensive care units.Materials and methods This retrospective observational study was conducted among adult patients who received a minimum of 48 h of intravenous colistin from January 2020 to December 2020 at the intensive care unit of a tertiary care hospital. AKI diagnosis and staging were made based on the Kidney Disease Improving Global Outcome Criteria.Results Of 148 patients who received intravenous colistin at a daily dose of 9 million IU, 54 (36%) developed AKI. In the univariate analysis, age, Charlson comorbidity index, APACHE II score, duration of colistin treatment, basal creatinine level, use of vasopressors, and vancomycin were significantly associated with AKI (p < 0.05). The multivariate analysis revealed that the independent predictor of AKI was the use of vasopressors (OR: 3.14; 95% confidence interval: 1.39-97.07; p = 0.06).Conclusion The use of vasopressors in critically ill patients was independently associated with AKI developing during colistin treatment.
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Keywords
Acute kidney injury, Infectious-diseases society, Critically-ill patients, Severe sepsis, Risk-factors, Care, Polymyxins, Norepinephrine, Pharmacology, Guidelines, Intensive care unit, Colistin, Acute kidney injury, Vasopressor, Science & technology, Life sciences & biomedicine, Urology & nephrology