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Etiology, clinic and prognosis of seizures in preterm and term neonates: A retrospective study

dc.contributor.buuauthorCakir, Salih Cagri
dc.contributor.buuauthorÇAKIR, SALİH ÇAĞRI
dc.contributor.buuauthorToker, Rabia Tutuncu
dc.contributor.buuauthorTÜTÜNCÜ TOKER, RABİA
dc.contributor.buuauthorKoksal, Nilgun
dc.contributor.buuauthorOzkan, Hilal
dc.contributor.buuauthorÖZKAN, HİLAL
dc.contributor.buuauthorOkan, Mehmet Sait
dc.contributor.buuauthorOKAN, MEHMET SAİT
dc.contributor.buuauthorKocael, Fatma
dc.contributor.buuauthorKOCAEL, FATMA
dc.contributor.buuauthorYoruk, Gulce
dc.contributor.buuauthorYÖRÜK, GÜLCE
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dali
dc.contributor.orcid0000-0001-5761-4757
dc.contributor.orcid0000-0002-3129-334X
dc.contributor.orcid0000-0002-9303-5768
dc.contributor.orcid0000-0002-1787-6872
dc.contributor.researcheridIZP-6290-2023
dc.contributor.researcheridHJZ-4508-2023
dc.date.accessioned2024-06-28T11:50:54Z
dc.date.available2024-06-28T11:50:54Z
dc.date.issued2021-08-01
dc.description.abstractIntroduction: The seizure is one of the most common neurological problems in neonatal intensive care units (NICU). Its frequency and etiology differ between preteen and term babies. This study aimed to investigate the properties, causes, response to treatment, and prognostic factors of neonatal seizures in term and preterm babies.Materials and Methods: The files of patients with a diagnosis of neonatal seizure in the NICU between 01/01/2014 and 01/09/2019 were analyzed retrospectively. Gross motor function classification, hearing test results and epilepsy rates were examined for neurological outcomes.Results: A total of 86 patients (43 preterm and 43 term infants) were included in this study. The most common etiological factors were hypoxic-ischemic encephalopathy (HIE) (35%) in term infants and intraventricular hemorrhage (IVH) in preterm infants (54%). The most common seizure type was subtle seizures in preterm babies and clonic seizures in term babies. The first seizure day was more on the first day and between the 4-7 days in term babies and after seventh days in preterm babies (p <0.05). The onset time of seizures in preterm babies was more after seven days at IVH, and on the first day at HIE (p<0.05). Status epilepticus frequency is higher in preterm (30%) than term (9.3%) (p = 0.015). The response rate to phenobarbital treatment was 71% in term infants and 50% in preterm infants (p = 0.06). According to the criteria (death, epilepsy, hearing loss, autism and gross motor function scale> 2) in our study, the poor prognosis rates were (52%) in term infants and (75%) in preterm infants (p = 0.051).Conclusion: In the etiology of neonatal seizures, IVH in preterm infants and HIE in term infants were the first. The neurological outcomes of patients who had convulsions in the neonatal period should be followed closely.
dc.identifier.doi10.4274/jcp.2021.0026
dc.identifier.endpage211
dc.identifier.issn1304-9054
dc.identifier.issue2
dc.identifier.startpage203
dc.identifier.urihttps://doi.org/10.4274/jcp.2021.0026
dc.identifier.urihttps://hdl.handle.net/11452/42596
dc.identifier.volume19
dc.identifier.wos000791557000007
dc.indexed.wosWOS.ESCI
dc.language.isoen
dc.publisherBursa Uludag Üniversitesi
dc.relation.journalGuncel Pediatri-journal Of Current Pediatrics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectGross motor function
dc.subjectCerebral-palsy
dc.subjectClassification
dc.subjectLevetiracetam
dc.subjectReliability
dc.subjectProfile
dc.subjectSystem
dc.subjectNeonatal seizures
dc.subjectNewborn
dc.subjectNeurological outcomes
dc.subjectStatus epilepticus
dc.subjectAnticonvulsant therapy
dc.subjectScience & technology
dc.subjectLife sciences & biomedicine
dc.subjectPediatrics
dc.subjectPediatrics
dc.titleEtiology, clinic and prognosis of seizures in preterm and term neonates: A retrospective study
dc.typeArticle
dspace.entity.typePublication
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relation.isAuthorOfPublication2117fbaa-f41b-481d-afa1-416b275458f0
relation.isAuthorOfPublication67242d15-556e-43b2-a23e-e80ce158b468
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relation.isAuthorOfPublicationba6e92a6-680a-4884-b6d9-815a338f8c7d
relation.isAuthorOfPublication79ab435a-286c-4432-9421-e046b0decd92
relation.isAuthorOfPublication.latestForDiscovery03619423-bd8d-460b-9acf-ae9ba7999208

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