Publication:
Combined application of human amniotic membrane wrapping and hyaluronic acid injection in epineurectomized rat sciatic nerve

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dc.contributor.buuauthorÖzgenel, Güzin Yeşim
dc.contributor.buuauthorFiliz, Gülaydan
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıbbi Patoloji Ana Bilim Dalı
dc.contributor.departmentPlastik ve Rekonstrüktif Cerrahi Ana Bilim Dalı
dc.contributor.orcid0000-0003-0000-8355
dc.contributor.researcheridAAH-4233-2021
dc.contributor.scopusid6701823106
dc.contributor.scopusid6602693514
dc.date.accessioned2021-10-07T11:13:51Z
dc.date.available2021-10-07T11:13:51Z
dc.date.issued2004-02
dc.description.abstractThe purpose of this study was to investigate the effects of combined application of human amniotic membrane wrapping and hyaluronic acid injection on peripheral nerve scarring in an adult rat model. After circumferential epineurectomies of right sciatic nerves were performed in each of 72 rats, nerves were randomly divided into three groups: (1) nothing was done additional to epineurectomy; (2) the epineurectomized segment was wrapped with human amniotic membrane; and (3) the epineurectomized segment was wrapped with human amniotic membrane and hyaluronic acid was injected inside. The extent of adhesions and perineurial scar thickness was macroscopically and histologically evaluated at 4 and 12 weeks. The least adhesion and perineurial scar tissue were observed in nerves treated with human amniotic membrane wrapping and hyaluronic acid injection. This combination appears to be safe and effective in preventing perineurial scar formation after peripheral nerve surgery in rats.
dc.identifier.citationÖzgenel, G.Y. ve Filiz, G. (2004). “Combined application of human amniotic membrane wrapping and hyaluronic acid injection in epineurectomized rat sciatic nerve”. Journal of Reconstructive Microsurgery, 20(2), 153-157.
dc.identifier.endpage157
dc.identifier.issn0743-684X
dc.identifier.issue2
dc.identifier.pubmed15011124
dc.identifier.scopus2-s2.0-1342287196
dc.identifier.startpage153
dc.identifier.urihttps://doi.org/10.1055/s-2004-820772
dc.identifier.urihttps://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-2004-820772
dc.identifier.urihttp://hdl.handle.net/11452/22280
dc.identifier.volume20
dc.identifier.wos000189275300007
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherThieme
dc.relation.journalJournal of Reconstructive Microsurgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectSurgery
dc.subjectHyaluronic acid
dc.subjectHuman amniotic membrane
dc.subjectPeripheral nerve scarring
dc.subjectCarpal-tunnel syndrome
dc.subjectPeripheral-nerve
dc.subjectMedian nerve
dc.subjectNeuropathy
dc.subjectGraft
dc.subjectTransplantation
dc.subjectRabbits
dc.subjectAdjunct
dc.subjectFluid
dc.subjectFlap
dc.subject.emtreeHyaluronic acid
dc.subject.emtreeAdhesion
dc.subject.emtreeAmnion
dc.subject.emtreeAnimal model
dc.subject.emtreeAnimal tissue
dc.subject.emtreeArticle
dc.subject.emtreeHistology
dc.subject.emtreeHuman
dc.subject.emtreeHuman tissue
dc.subject.emtreeMale
dc.subject.emtreeMuscle
dc.subject.emtreeNerve compression
dc.subject.emtreeNeurectomy
dc.subject.emtreeNonhuman
dc.subject.emtreePeripheral nerve
dc.subject.emtreePriority journal
dc.subject.emtreeRat
dc.subject.emtreeScar
dc.subject.emtreeScar formation
dc.subject.emtreeSciatic nerve
dc.subject.emtreeSkin
dc.subject.meshAdhesions
dc.subject.meshAdjuvants, immunologic
dc.subject.meshAnimals
dc.subject.meshBiological dressings
dc.subject.meshCicatrix
dc.subject.meshCombined modality therapy
dc.subject.meshHyaluronic acid
dc.subject.meshInjections, intralesional
dc.subject.meshMale
dc.subject.meshModels, animal
dc.subject.meshPeripheral nerves
dc.subject.meshRats
dc.subject.meshRats, Sprague-Dawley
dc.subject.meshSciatic nerve
dc.subject.meshSciatic neuropathy
dc.subject.scopusNeuroma; Median Neuropathy; Phantom Limb
dc.subject.wosSurgery
dc.titleCombined application of human amniotic membrane wrapping and hyaluronic acid injection in epineurectomized rat sciatic nerve
dc.typeArticle
dc.wos.quartileQ3
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Plastik ve Rekonstrüktif Cerrahi Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Tıbbi Patoloji Ana Bilim Dalı
local.indexed.atScopus
local.indexed.atWOS

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