Publication: A transient early hbv-dna increase during peg-ifnα therapy of hepatitis d indicates loss of infected cells and is associated with hdv-rna and hbsag reduction
dc.contributor.author | Anastasiou, Olympia E. | |
dc.contributor.author | Yurdaydin, Cihan | |
dc.contributor.author | Maasoumy, Benjamin | |
dc.contributor.author | Hardtke, Svenja | |
dc.contributor.author | Caruntu, Florin Alexandru | |
dc.contributor.author | Curescu, Manuela G. | |
dc.contributor.author | Yalcin, Kendal | |
dc.contributor.author | Akarca, Ulus S. | |
dc.contributor.author | Zeuzem, Stefan | |
dc.contributor.author | Erhardt, Andreas | |
dc.contributor.author | Luth, Stefan | |
dc.contributor.author | Papatheodoridis, George, V | |
dc.contributor.author | Radu, Monica | |
dc.contributor.author | Liebig, Stephanie | |
dc.contributor.author | Bantel, Heike | |
dc.contributor.author | Bremer, Birgit | |
dc.contributor.author | Manns, Michael P. | |
dc.contributor.author | Cornberg, Markus | |
dc.contributor.author | Wedemeyer, Heiner | |
dc.contributor.buuauthor | Gürel, Selim | |
dc.contributor.buuauthor | GÜREL, SELİM | |
dc.contributor.department | Bursa Uludağ Üniversitesi/Tıp Fakültesi | |
dc.contributor.researcherid | HLH-8209-2023 | |
dc.date.accessioned | 2024-07-09T07:40:45Z | |
dc.date.available | 2024-07-09T07:40:45Z | |
dc.date.issued | 2020-12-12 | |
dc.description.abstract | HBV-DNA levels are low or even undetectable in the majority HDV-infected patients. The impact of PEG-IFN alpha on HBV-DNA kinetics in HDV-infected patients has not been studied in detail. We analysed data of a prospective treatment trial where 120 HDV-RNA-positive patients were randomized to receive PEG-IFN alpha-2a plus tenofovir-disoproxil-fumarate (PEG-IFN alpha/TDF, n = 59) or placebo (PEG-IFN alpha/PBO; n = 61) for 96 weeks. At week 96, HBV-DNA was still quantifiable in 71% of PEG-IFN alpha/PBO-treated patients but also in 76% of PEG-IFN alpha/TDF-treated patients, despite low HBV-DNA baseline values. Surprisingly, a transient HBV-DNA increase between weeks 12 and 36 was observed in 12 in PEG-IFN alpha/TDF-treated and 12 PEG-IFN alpha/PBO-treated patients. This increase was positively associated with HBsAg loss [(P = 0.049, odds ratio (OR) 5.1] and HDV-RNA suppression (P = 0.007, OR 4.1) at week 96. Biochemical markers of cell death (M30 and ALT) were higher during the HBV-DNA peak but no distinct systemic immune pattern could be observed by screening 91 soluble inflammatory markers. In conclusion, an early increase in HBV-DNA during PEG-IFN alpha-2a therapy occurred in more than 20% of patients, even in TDF-treated patients. This transient HBV-DNA rise may indicate PEG-IFN alpha-induced cell death and lead to long-term HDV-RNA suppression and HBsAg loss. | |
dc.description.sponsorship | HepNet Study-House (German Center for Infection Research) | |
dc.description.sponsorship | HepNet Study-House (German Ministry for Education and Research) | |
dc.description.sponsorship | HepNet Study-House (German Liver Foundation) | |
dc.identifier.doi | 10.1111/jvh.13439 | |
dc.identifier.endpage | 419 | |
dc.identifier.issn | 1352-0504 | |
dc.identifier.issue | 2 | |
dc.identifier.startpage | 410 | |
dc.identifier.uri | https://doi.org/10.1111/jvh.13439 | |
dc.identifier.uri | https://hdl.handle.net/11452/43069 | |
dc.identifier.volume | 28 | |
dc.identifier.wos | 000597760100001 | |
dc.indexed.wos | WOS.SCI | |
dc.language.iso | en | |
dc.publisher | Wiley | |
dc.relation.journal | Journal Of Viral Hepatitis | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | Tenofovir disoproxil fumarate | |
dc.subject | D virus | |
dc.subject | Replication | |
dc.subject | Combination | |
dc.subject | Induction | |
dc.subject | Responses | |
dc.subject | Kinetics | |
dc.subject | Adefovir | |
dc.subject | Innate | |
dc.subject | Drug | |
dc.subject | Hbv | |
dc.subject | Hepatitis b | |
dc.subject | Hepatitis d | |
dc.subject | Interferon | |
dc.subject | Viral kinetics | |
dc.subject | Science & technology | |
dc.subject | Life sciences & biomedicine | |
dc.subject | Gastroenterology & hepatology | |
dc.subject | Infectious diseases | |
dc.subject | Virology | |
dc.title | A transient early hbv-dna increase during peg-ifnα therapy of hepatitis d indicates loss of infected cells and is associated with hdv-rna and hbsag reduction | |
dc.type | Article | |
dspace.entity.type | Publication | |
relation.isAuthorOfPublication | d7a9ea11-69fc-4122-a365-8fb2123512e6 | |
relation.isAuthorOfPublication.latestForDiscovery | d7a9ea11-69fc-4122-a365-8fb2123512e6 |