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Role of central arginine vasopressin receptors in the analgesic effect of CDP-choline on acute and neuropathic pain

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dc.contributor.buuauthorBaǧdaş, Deniz
dc.contributor.buuauthorÖzbölük, Hasret Yücel
dc.contributor.buuauthorOrhan, Fulya
dc.contributor.buuauthorKanat, Özkan
dc.contributor.buuauthorBüyükcoşkun, Naciye Işbil
dc.contributor.buuauthorGürün, Mine Sibel
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentFarmokoloji Ana Bilim Dalı
dc.contributor.departmentFizyoloji Ana Bilim Dalı
dc.contributor.researcheridAAH-1692-2021
dc.contributor.researcheridAAG-8716-2019
dc.contributor.scopusid15062425700
dc.contributor.scopusid55865772300
dc.contributor.scopusid55866311800
dc.contributor.scopusid55881548500
dc.contributor.scopusid55665951400
dc.contributor.scopusid55664349700
dc.date.accessioned2023-05-17T12:06:45Z
dc.date.available2023-05-17T12:06:45Z
dc.date.issued2013-12-04
dc.description.abstractRecent studies have demonstrated that arginine vasopressin (AVP) plays a crucial role in pain modulation. In addition, our previous studies have proven that centrally administered cytidine-5-diphosphate-choline (CDP-choline; citicoline) elicits an analgesic effect in different pain models in rats. Given that CDP-choline enhances central and peripheral vasopressin levels, the present study was designed to investigate the role of central AVP receptors in the analgesic effect of CDP-choline in acute and chronic constriction injury-induced neuropathic pain models. For this purpose, rats were pretreated intracerebroventricularly with the AVP V-1 or AVP V-2 receptor antagonist 15 min before intracerebroventricular injection of CDP-choline or saline, and pain threshold was determined using the Randall-Selitto test. AVP V-1 and AVP V-2 receptor antagonist blocked the CDP-choline-induced analgesic effect either in acute or neuropathic models of pain in rats. These results suggest, for the first time, that central AVP receptors are involved in the CDP-choline-elicited analgesic effect.
dc.identifier.citationBağdaş, D. vd. (2013). “Role of central arginine vasopressin receptors in the analgesic effect of CDP-choline on acute and neuropathic pain”. Neuroreport, 24(17), 941-946.
dc.identifier.endpage946
dc.identifier.issn0959-4965
dc.identifier.issn1473-558X
dc.identifier.issue17
dc.identifier.pubmed24089014
dc.identifier.scopus2-s2.0-84887096620
dc.identifier.startpage941
dc.identifier.urihttps://doi.org/10.1097/WNR.0000000000000009
dc.identifier.urihttp://hdl.handle.net/11452/32700
dc.identifier.volume24
dc.identifier.wos000326582800002
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherLippincott Williams and Wilkins
dc.relation.bapT(U) 2009/9
dc.relation.journalNeuroreport
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectNeurosciences & neurology
dc.subjectAcute pain
dc.subjectAnalgesia
dc.subjectArginine vasopressin
dc.subjectCDP-choline
dc.subjectNeuropathic pain
dc.subjectPeriaqueductal gray
dc.subjectAntinociception
dc.subjectRat
dc.subjectInvolvement
dc.subjectNociception
dc.subjectNuclei
dc.subjectModels
dc.subject.emtreeArgipressin receptor
dc.subject.emtreeCiticoline
dc.subject.emtreeAnalgesic activity
dc.subject.emtreeAnimal experiment
dc.subject.emtreeAnimal model
dc.subject.emtreeAntinociception
dc.subject.emtreeArticle
dc.subject.emtreeControlled study
dc.subject.emtreeMale
dc.subject.emtreeNerve ligation
dc.subject.emtreeNeuropathic pain
dc.subject.emtreeNonhuman
dc.subject.emtreePain threshold
dc.subject.emtreePriority journal
dc.subject.emtreeRat
dc.subject.meshAcute pain
dc.subject.meshAnalgesics
dc.subject.meshAnimals
dc.subject.meshArginine vasopressin
dc.subject.meshBrain
dc.subject.meshCytidine diphosphate choline
dc.subject.meshMale
dc.subject.meshNeuralgia
dc.subject.meshPain measurement
dc.subject.meshPain threshold
dc.subject.meshRats
dc.subject.meshRats, Sprague-Dawley
dc.subject.meshReceptors, vasopressin
dc.subject.scopusPain; Atosiban; Vasopressins
dc.subject.wosNeurosciences
dc.titleRole of central arginine vasopressin receptors in the analgesic effect of CDP-choline on acute and neuropathic pain
dc.typeArticle
dc.wos.quartileQ4
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Farmokoloji Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Fizyoloji Ana Bilim Dalı
local.indexed.atScopus
local.indexed.atWOS

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