Publication:
Stimulus properties of venlafaxine in a conditioned taste aversion procedure

No Thumbnail Available

Date

2008-10-31

Authors

Göktalay, Gökhan

Authors

Kayır, Hakan
Alıcı, Tevfik
Yıldırım, Murat
Ulusoy, Kemal Gökhan
Ceyhan, Mert
Çelik, Turgay
Uzbay, Tayfun

Journal Title

Journal ISSN

Volume Title

Publisher

Elsevier

Research Projects

Organizational Units

Journal Issue

Abstract

Conditioned stimulus properties of venlafaxine are still unknown. In the present study, the discriminative stimulus properties of venlafaxine by using a conditioned taste aversion procedure were investigated. Swiss Webster mice were allowed to reach water from 2 pipettes for 20 min (09:00-11:30 h), plus 30 min (15:3016:00 h), daily. During the 4 days, the test drugs [fluoxetine, escitalopram, tianeptine, reboxetine, and N omega-nitro-L-arginine methyl ester(L-NAME)l were injected to mice at least 1 h after they had first water session. On day 5, they consumed glucose solution(5%w/v) and immediately injected with conditioning drug (venlafaxine 32 mg/kg). On day 8, mice were allowed to make a choice between water and glucose solution. The amount of glucose consumption as a percentage of total fluid intakes was calculated for each animal. Significant reduction in glucose choice was defined as conditioned taste aversion. Venlafaxine (32 mg/kg) induced a robust conditioned taste aversion in mice. Pre-exposure to tianeptine (2.5-10 mg/kg), fluoxetine (10 mg/kg), escitalopram (32 mg/kg), and reboxetine (5 mg/kg) substituted for venlafaxine by preventing the conditioned taste aversion induced by venlafaxine. L-NAME did not substitute for venlafaxine. Substitution of venlafaxine by fluoxetine, tianeptine, escitalopram, and reboxetine provides further evidence that both 5-HT and noradrenaline reuptake inhibition may play an important role in the stimulus effect of venlafaxine.

Description

Keywords

(Mice), Antidepressant, Conditioned taste aversion, Escitalopram, Fluoxetine, I- name, Reboxetine, Tianeptine, Venlafaxine, Serotonin reuptake inhibitor, Discriminative stimulus, Antidepressant, Citalopram, Drugs, Pharmacology & pharmacy

Citation

Kayır, H. vd. (2008). "Stimulus properties of venlafaxine in a conditioned taste aversion procedure". European Journal of Pharmacology, 596(1-3), 102-106.

0

Views

0

Downloads

Search on Google Scholar