Publication:
Cytokine gene polymorphisms in Behçet's disease and their association with clinical and laboratory findings

dc.contributor.authorÖzçimen, Ahmet Ata
dc.contributor.buuauthorDilek, Kamil
dc.contributor.buuauthorSancaoğlu, Hayriye
dc.contributor.buuauthorSaba, Davit
dc.contributor.buuauthorYücel, Ali
dc.contributor.buuauthorYurtkuran, Mustafa Abbas
dc.contributor.buuauthorYurtkuran, Merih
dc.contributor.buuauthorOral, Haluk Barbaros
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentNefroloji ve Romatoloji Ana Bilim Dalı
dc.contributor.departmentDermatoloji Ana Bilim Dalı
dc.contributor.departmentKalp Damar Cerrahisi Ana Bilim Dalı
dc.contributor.orcid0000-0003-0463-6818
dc.contributor.researcheridK-7285-2012
dc.contributor.scopusid56005080200
dc.contributor.scopusid35485529800
dc.contributor.scopusid55987378200
dc.contributor.scopusid57225839918
dc.contributor.scopusid55408539300
dc.contributor.scopusid7003389525
dc.contributor.scopusid7004498001
dc.date.accessioned2021-11-26T10:16:24Z
dc.date.available2021-11-26T10:16:24Z
dc.date.issued2009
dc.description.abstractThe association of the cytokine gene polymorphisms with the development of Behcet's Disease (BD) was investigated in this study. DNA samples were obtained from a Turkish population of 97 unrelated patients with BD, and 12 7 unrelated health), control subjects. All genotyping (IL-6, IL10, IFN-gamma, TGF-beta 1 and TNF-alpha) experiments were performed using sequence-specific primers PCR. The frequency of TGF-beta 1 codon 25 GG genotype was found significantly lower in BD patients compared to healthy control subjects. The IL-10 -1082 GA genotype was more frequent whereas the AA genotype was less common in the BD group compared to the control group. The association between clinial findings and cytokine gene polymorphisms was further investigated in the patients with BD. The frequency of IFN-gamma AA genotype was lower in the patients with genital ulcer. Additionally, it was found that the frequency of IL-6 -174 GG genotype was lower in the patients with Pathergy positivity. These results suggest that TGF-beta 1 and IL-10 gene polymorphisms may affect host susceptibility to BD. Also, to confirm the biological significance of our results, further studies should be performed on other population groups and in large number of cases.
dc.identifier.citationDilek, K. vd. (2009). "Cytokine gene polymorphisms in Behçet's disease and their association with clinical and laboratory findings". Clinical and Experimental Rheumatology, 27(2), Supplement 53, 73-78.
dc.identifier.endpage78
dc.identifier.issn0392-856X
dc.identifier.issue2 Supplement 53
dc.identifier.pubmed19796538
dc.identifier.scopus2-s2.0-70350141054
dc.identifier.startpage73
dc.identifier.urihttp://hdl.handle.net/11452/22825
dc.identifier.volume27
dc.identifier.wos000272424000015
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherClinical & Exper Rheumatology
dc.relation.bapT-2004/59
dc.relation.collaborationYurt içi
dc.relation.journalClinical and Experimental Rheumatology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCytokine
dc.subjectGenotyping
dc.subjectPCR-SSP
dc.subjectBehcet's disease
dc.subjectTGF-beta
dc.subjectIL-10
dc.subjectNecrosis-factor-alpha
dc.subjectPromoter polymorphisms
dc.subjectInterleukin-10 il-10
dc.subjectSusceptibility
dc.subjectTnf
dc.subjectGrowth
dc.subjectSuppression
dc.subjectMonocytes
dc.subjectCells
dc.subjectTh17
dc.subjectRheumatology
dc.subject.emtreeGamma interferon
dc.subject.emtreeInterleukin 10
dc.subject.emtreeInterleukin 6
dc.subject.emtreeTransforming growth factor beta1
dc.subject.emtreeTumor necrosis factor alpha
dc.subject.emtreeArticle
dc.subject.emtreeBehcet disease
dc.subject.emtreeCodon
dc.subject.emtreeControlled study
dc.subject.emtreeDisease predisposition
dc.subject.emtreeDNA determination
dc.subject.emtreeErythema nodosum
dc.subject.emtreeEye disease
dc.subject.emtreeGene frequency
dc.subject.emtreeGene sequence
dc.subject.emtreeGenetic association
dc.subject.emtreeGenetic susceptibility
dc.subject.emtreeGenital ulcer
dc.subject.emtreeGenotype
dc.subject.emtreeHuman
dc.subject.emtreeLaboratory test
dc.subject.emtreeMajor clinical study
dc.subject.emtreePolymerase chain reaction
dc.subject.emtreePriority journal
dc.subject.emtreeSingle nucleotide polymorphism
dc.subject.meshBehcet syndrome
dc.subject.meshCase-control studies
dc.subject.meshGene frequency
dc.subject.meshGenetic predisposition to disease
dc.subject.meshGenotype
dc.subject.meshHumans
dc.subject.meshInterferon-gamma
dc.subject.meshInterleukin-10
dc.subject.meshInterleukin-6
dc.subject.meshPolymorphism, single nucleotide
dc.subject.meshTransforming growth factor beta1
dc.subject.meshTumor necrosis factor-alpha
dc.subject.scopusBehcet Syndrome; Uveitis; Infliximab
dc.subject.wosRheumatology
dc.titleCytokine gene polymorphisms in Behçet's disease and their association with clinical and laboratory findings
dc.typeArticle
dc.wos.quartileQ3
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Nefroloji ve Romatoloji Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Dermatoloji Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Kalp Damar Cerrahisi Ana Bilim Dalı
local.indexed.atPubMed
local.indexed.atWOS

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