Publication:
Molecular identification, genotyping, and drug susceptibility of the basidiomycetous yeast pathogen Trichosporon isolated from Turkish patients

dc.contributor.authorKalkancı, Ayşe
dc.contributor.authorSugita, Takashi
dc.contributor.authorArıkan, Sevtap Akdağlı
dc.contributor.authorYücesoy, Mine
dc.contributor.authorOtağ, Feza
dc.contributor.authorKiraz, Nuri
dc.contributor.authorKuştimur, Semra
dc.contributor.authorSancak, Banu
dc.contributor.authorEmektaş, Gürol
dc.contributor.buuauthorEner, Beyza
dc.contributor.buuauthorEvci, Canan
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentEnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Ana Bilim Dalı
dc.contributor.orcid0000-0002-4803-8206
dc.contributor.researcheridAAG-8523-2021
dc.contributor.scopusid15053025300
dc.contributor.scopusid22034011200
dc.date.accessioned2022-08-22T05:51:37Z
dc.date.available2022-08-22T05:51:37Z
dc.date.issued2010-02
dc.description.abstractDeep-seated infections due to Trichosporon species are emerging mycoses that have a very poor prognosis in patients with persistent neutropenia. This study elucidated the mycological characteristics of Trichosporon strains obtained from deep-seated infections in Turkish patients and identified by DNA sequence analysis of intergenic spacer (IGS) region 1 of the rDNA locus. In addition, we genotyped the major causative agent, T asahii, and evaluated the in vitro drug susceptibility of the isolates. While 87 (81.3%) of the 107 isolates were T asahii, the remaining 20 were T. faecale (14.0%), T asteroids (0.9%), T. coremiiforme (0.9%), T japonicum, (0.9%), T. lactis (0.9%), and a new species (0.9%). In addition to the eight known T. asahii genotypes, one novel genotype was identified. The distribution of the T. asahii genotypes in this study were genotype 1 (79.3%), followed by 5 (8.0%), 3 (6.9%), 6 (3.4%), 4 (1.1%), and 9 (1.1%). Turkish isolates showed low susceptibility to amphotericin 13, 5-flucytosine, and fluconazole. Although relatively low minimum inhibitory concentrations (MICs) were found with all drugs, voriconazole appeared to be the most active. The MICs of the non-Trichosporon asahiiTrichosporon species were similar to those of the T. asahii strains. Our findings suggest that Trichosporon species isolated from Turkish patients are more diverse than those reported from other countries.
dc.description.sponsorshipMinistry of Health, Labour and Welfare, Japan
dc.description.sponsorshipMinistry of Education, Culture, Sports, Science and Technology, Japan (MEXT)
dc.description.sponsorshipMeiji Pharmaceutical University
dc.identifier.citationKalkancı, A. vd. (2010). "Molecular identification, genotyping, and drug susceptibility of the basidiomycetous yeast pathogen Trichosporon isolated from Turkish patients". Medical Mycology, 48(1), 141-146.
dc.identifier.endpage146
dc.identifier.issn1369-3786
dc.identifier.issn1460-2709
dc.identifier.issue1
dc.identifier.pubmed19462333
dc.identifier.scopus2-s2.0-74949131584
dc.identifier.startpage141
dc.identifier.urihttps://doi.org/10.3109/13693780902977984
dc.identifier.urihttps://academic.oup.com/mmy/article/48/1/141/1244334?login=true
dc.identifier.urihttp://hdl.handle.net/11452/28284
dc.identifier.volume48
dc.identifier.wos000274739900017
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherOxford University
dc.relation.collaborationYurt içi
dc.relation.collaborationYurt dışı
dc.relation.journalMedical Mycology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTrichosporon asahii
dc.subjectGenotype
dc.subjectDrug susceptibility
dc.subjectTurkey
dc.subjectIntergenic spacer-1
dc.subjectSequence-analysis
dc.subjectFungal pathogens
dc.subjectAmphotericin-B
dc.subjectPichia-anomala
dc.subjectAsahii
dc.subjectInfection
dc.subjectRegions
dc.subjectMalignancies
dc.subjectDiversity
dc.subjectInfectious diseases
dc.subjectMycology
dc.subjectVeterinary sciences
dc.subjectTrichosporon asahii
dc.subjectTrichosporon coremiiforme
dc.subjectTrichosporon faecale
dc.subjectTrichosporon japonicum
dc.subjectTrichosporon lactis
dc.subject.emtreeAmphotericin B
dc.subject.emtreeFluconazole
dc.subject.emtreeFlucytosine
dc.subject.emtreeRibosome DNA
dc.subject.emtreeSpacer DNA
dc.subject.emtreeVoriconazole
dc.subject.emtreeAntifungal agent
dc.subject.emtreeFungal DNA
dc.subject.emtreeRibosomal spacer DNA
dc.subject.emtreeRibosome DNA
dc.subject.emtreeArticle
dc.subject.emtreeBasidiomycetes
dc.subject.emtreeControlled study
dc.subject.emtreeDNA sequence
dc.subject.emtreeDrug sensitivity
dc.subject.emtreeFungal strain
dc.subject.emtreeGenotype
dc.subject.emtreeMinimum inhibitory concentration
dc.subject.emtreeMycosis
dc.subject.emtreeNonhuman
dc.subject.emtreeNucleotide sequence
dc.subject.emtreePathogenesis
dc.subject.emtreeTrichosporon
dc.subject.emtreeTrichosporon asahii
dc.subject.emtreeTrichosporon asteroids
dc.subject.emtreeTrichosporon coremiiforme
dc.subject.emtreeTrichosporon faecale
dc.subject.emtreeTrichosporon japonicum
dc.subject.emtreeTrichosporon lactis
dc.subject.emtreeTurkey (republic)
dc.subject.emtreeYeast
dc.subject.emtreeChemistry
dc.subject.emtreeClassification
dc.subject.emtreeCluster analysis
dc.subject.emtreeDrug effects
dc.subject.emtreeGenetics
dc.subject.emtreeHuman
dc.subject.emtreeIsolation and purification
dc.subject.emtreeMicrobial sensitivity test
dc.subject.emtreeMicrobiology
dc.subject.emtreeMycosis
dc.subject.emtreePhylogeny
dc.subject.emtreeTrichosporon
dc.subject.emtreeTurkey
dc.subject.meshAntifungal agents
dc.subject.meshCluster analysis
dc.subject.meshDNA, fungal
dc.subject.meshDNA, ribosomal
dc.subject.meshDNA, ribosomal spacer
dc.subject.meshGenotype
dc.subject.meshHumans
dc.subject.meshMicrobial sensitivity tests
dc.subject.meshMycoses
dc.subject.meshPhylogeny
dc.subject.meshSequence analysis, DNA
dc.subject.meshTrichosporon
dc.subject.meshTurkey
dc.subject.scopusTrichosporon Asahii; Infection; Geotrichum
dc.subject.wosInfectious diseases
dc.subject.wosMycology
dc.subject.wosVeterinary sciences
dc.titleMolecular identification, genotyping, and drug susceptibility of the basidiomycetous yeast pathogen Trichosporon isolated from Turkish patients
dc.typeArticle
dc.wos.quartileQ1
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Ana Bilim Dalı
local.indexed.atScopus
local.indexed.atWOS

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