Publication:
Systemic immune inflammation index in ankylosing spondylitis patients

dc.contributor.authorMısırcı, Salim
dc.contributor.authorAlp, Alev
dc.contributor.authorAltan, Lale
dc.contributor.authorYılmaz, Büşra Başar
dc.contributor.buuauthorMISIRCI, SALİM
dc.contributor.buuauthorALP, ALEV
dc.contributor.buuauthorALTAN İNCEOĞLU, LALE
dc.contributor.buuauthorYılmaz, Büşra Başar
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentFiziksel Tıp ve Rehabilitasyon Ana Bilim Dalı
dc.contributor.departmentBiyoistatistik Ana Bilim Dalı
dc.contributor.researcheridDHX-0337-2022
dc.contributor.researcheridEKZ-2544-2022
dc.contributor.researcheridJWQ-3548-2024
dc.contributor.researcheridLDE-2072-2024
dc.date.accessioned2025-02-06T08:24:36Z
dc.date.available2025-02-06T08:24:36Z
dc.date.issued2024-04-01
dc.description.abstractObjective: Our objective was to assess the relationship between disease activity and the systemic immune -inflammation index [SII; (platelet count x neutrophil count / lymphocyte count)] in individuals with ankylosing spondylitis (AS). Materials and Methods: A total of 201 participants (130 AS patients and 71 healthy volunteers) aged 18-65 years were included in this single center cross-sectional study. Based on their ratings on the Bath Ankylosing Spondylitis Disease Activity index (BASDAI), patients with AS were split into two groups: remission (n=90, those with BASDAI <4) and active disease (n=40, those with BASDAI >4). The study employed Spearman correlation analysis to assess the relationship between SII and C -reactive protein (CRP), erythrocyte sedimentation rate (ESR), BASDAI, Ankylosing Spondylitis Disease Activity score-ESR (ASDAS-ESR), and ASDAS-CRP. The effectiveness of SII and other measures in evaluating the disease activity in the active AS and remission AS groups was ascertained using receiver operating characteristic curve analysis. Results: SII values were significantly higher in the AS group than healthy controls, as well as in the active AS group than AS patients in remission (p<0.001 for each). SII values were positively correlated with CRP [Spearman correlation coefficient (rs): 0.384, p<0.001], ESR (rs: 0.243, p=0.005), BASDAI (rs: 0.668, p<0.001), ASDAS-ESR (rs: 0.619, p<0.001) and ASDAS-CRP (rs: 0.700, p<0.001) values. The optimal cutoff value for the determination of AS disease activity was found to be 530.22x10 9 /L (area under the curve: 0.902, 95% confidence interval: 0.838-0.947, sensitivity: 72.50% and specificity: 92.22%). Conclusion: When assessing the activity of AS disease, SII appears to be a useful biomarker.
dc.identifier.doi10.4274/tod.galenos.2023.14892
dc.identifier.endpage29
dc.identifier.issn2147-2653
dc.identifier.issue1
dc.identifier.startpage22
dc.identifier.urihttps://doi.org/10.4274/tod.galenos.2023.14892
dc.identifier.urihttps://turkosteoporozdergisi.org/articles/doi/tod.galenos.2023.14892
dc.identifier.urihttps://hdl.handle.net/11452/50158
dc.identifier.volume30
dc.identifier.wos001279549900001
dc.indexed.wosWOS.ESCI
dc.language.isoen
dc.publisherGalenos Yayınevi
dc.relation.journalTürk Osteoporoz Dergisi-Turkish Journal of Osteoporosis
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectNeutrophil-lymphocyte ratio
dc.subjectDisease-activity
dc.subjectDrugs
dc.subjectAnkylosing spondylitis
dc.subjectC-reactive protein
dc.subjectNeutrophil to lymphocyte ratio
dc.subjectSystemic immune-inflammation index
dc.subjectRheumatology
dc.titleSystemic immune inflammation index in ankylosing spondylitis patients
dc.typeArticle
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Fiziksel Tıp ve Rehabilitasyon Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Biyoistatistik Ana Bilim Dalı
local.indexed.atWOS
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relation.isAuthorOfPublicationaeb31fbb-a4e9-4ed3-a5b8-16c1ffac93bd
relation.isAuthorOfPublication2aba29a4-d7c1-443c-8dec-31e291a1e5a8
relation.isAuthorOfPublication.latestForDiscovery37ca4e99-defa-49d6-b361-86c008db6da1

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