Publication: Systemic immune inflammation index in ankylosing spondylitis patients
dc.contributor.author | Mısırcı, Salim | |
dc.contributor.author | Alp, Alev | |
dc.contributor.author | Altan, Lale | |
dc.contributor.author | Yılmaz, Büşra Başar | |
dc.contributor.buuauthor | MISIRCI, SALİM | |
dc.contributor.buuauthor | ALP, ALEV | |
dc.contributor.buuauthor | ALTAN İNCEOĞLU, LALE | |
dc.contributor.buuauthor | Yılmaz, Büşra Başar | |
dc.contributor.department | Tıp Fakültesi | |
dc.contributor.department | Fiziksel Tıp ve Rehabilitasyon Ana Bilim Dalı | |
dc.contributor.department | Biyoistatistik Ana Bilim Dalı | |
dc.contributor.researcherid | DHX-0337-2022 | |
dc.contributor.researcherid | EKZ-2544-2022 | |
dc.contributor.researcherid | JWQ-3548-2024 | |
dc.contributor.researcherid | LDE-2072-2024 | |
dc.date.accessioned | 2025-02-06T08:24:36Z | |
dc.date.available | 2025-02-06T08:24:36Z | |
dc.date.issued | 2024-04-01 | |
dc.description.abstract | Objective: Our objective was to assess the relationship between disease activity and the systemic immune -inflammation index [SII; (platelet count x neutrophil count / lymphocyte count)] in individuals with ankylosing spondylitis (AS). Materials and Methods: A total of 201 participants (130 AS patients and 71 healthy volunteers) aged 18-65 years were included in this single center cross-sectional study. Based on their ratings on the Bath Ankylosing Spondylitis Disease Activity index (BASDAI), patients with AS were split into two groups: remission (n=90, those with BASDAI <4) and active disease (n=40, those with BASDAI >4). The study employed Spearman correlation analysis to assess the relationship between SII and C -reactive protein (CRP), erythrocyte sedimentation rate (ESR), BASDAI, Ankylosing Spondylitis Disease Activity score-ESR (ASDAS-ESR), and ASDAS-CRP. The effectiveness of SII and other measures in evaluating the disease activity in the active AS and remission AS groups was ascertained using receiver operating characteristic curve analysis. Results: SII values were significantly higher in the AS group than healthy controls, as well as in the active AS group than AS patients in remission (p<0.001 for each). SII values were positively correlated with CRP [Spearman correlation coefficient (rs): 0.384, p<0.001], ESR (rs: 0.243, p=0.005), BASDAI (rs: 0.668, p<0.001), ASDAS-ESR (rs: 0.619, p<0.001) and ASDAS-CRP (rs: 0.700, p<0.001) values. The optimal cutoff value for the determination of AS disease activity was found to be 530.22x10 9 /L (area under the curve: 0.902, 95% confidence interval: 0.838-0.947, sensitivity: 72.50% and specificity: 92.22%). Conclusion: When assessing the activity of AS disease, SII appears to be a useful biomarker. | |
dc.identifier.doi | 10.4274/tod.galenos.2023.14892 | |
dc.identifier.endpage | 29 | |
dc.identifier.issn | 2147-2653 | |
dc.identifier.issue | 1 | |
dc.identifier.startpage | 22 | |
dc.identifier.uri | https://doi.org/10.4274/tod.galenos.2023.14892 | |
dc.identifier.uri | https://turkosteoporozdergisi.org/articles/doi/tod.galenos.2023.14892 | |
dc.identifier.uri | https://hdl.handle.net/11452/50158 | |
dc.identifier.volume | 30 | |
dc.identifier.wos | 001279549900001 | |
dc.indexed.wos | WOS.ESCI | |
dc.language.iso | en | |
dc.publisher | Galenos Yayınevi | |
dc.relation.journal | Türk Osteoporoz Dergisi-Turkish Journal of Osteoporosis | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | Neutrophil-lymphocyte ratio | |
dc.subject | Disease-activity | |
dc.subject | Drugs | |
dc.subject | Ankylosing spondylitis | |
dc.subject | C-reactive protein | |
dc.subject | Neutrophil to lymphocyte ratio | |
dc.subject | Systemic immune-inflammation index | |
dc.subject | Rheumatology | |
dc.title | Systemic immune inflammation index in ankylosing spondylitis patients | |
dc.type | Article | |
dspace.entity.type | Publication | |
local.contributor.department | Tıp Fakültesi/Fiziksel Tıp ve Rehabilitasyon Ana Bilim Dalı | |
local.contributor.department | Tıp Fakültesi/Biyoistatistik Ana Bilim Dalı | |
local.indexed.at | WOS | |
relation.isAuthorOfPublication | 37ca4e99-defa-49d6-b361-86c008db6da1 | |
relation.isAuthorOfPublication | aeb31fbb-a4e9-4ed3-a5b8-16c1ffac93bd | |
relation.isAuthorOfPublication | 2aba29a4-d7c1-443c-8dec-31e291a1e5a8 | |
relation.isAuthorOfPublication.latestForDiscovery | 37ca4e99-defa-49d6-b361-86c008db6da1 |
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