Publication:
Antioxidant treatment in dialysis patients - importance of ferritin

dc.contributor.buuauthorErsoy, Alpaslan
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentNefroloji Ana Bilim Dalı
dc.contributor.orcid0000-0002-0710-0923
dc.contributor.researcheridAAH-5054-2021
dc.contributor.scopusid35612977100
dc.date.accessioned2021-08-23T11:26:50Z
dc.date.available2021-08-23T11:26:50Z
dc.date.issued2006
dc.description.abstractSir, Cardiovascular disease remains one of the leading causes of mortality in haemodialysis (HD) patients. Abnormal oxidative stress and impaired antioxidant defence may contribute to accelerated atherogenesis associated with uraemia. I read with interest the article by Fumeron et al. [1], reporting that short-term oral vitamin C supplementation did not modify well-defined oxidative/antioxidative stress and inflammation markers in HD patients. As stated, they did not evaluate the effect of long-term intravenous vitamin C supplementation with lower or higher doses on oxidative stress, nor the efficacy of co-administration of vitamin E. Iron is a powerful oxidizing substance. Ferritin may have other functions in addition to its well-described role in storing intracellular iron. Elevated ferritin levels are associated with an increased risk of atherosclerotic coronary artery disease and myocardial infarction. Recent proteomics and molecular biology studies have shown that ferritin levels in arteries are increased in diseased tissues [2]. Ferritin may be unregulated under particular physiological conditions and may act as a pro-oxidant. In the mammalian cell, iron stored in ferritin can participate in initiating lipid peroxidation [3]. High levels of serum ferritin may indicate iron overload. However, in many patients results may be elevated due to inflammation, even if iron stores are not increased. Limited evidence shows that elevated iron stores and high-dose intravenous iron therapy may increase morbidity and mortality in HD patients [4], and exacerbate increased oxidative stress in uraemic patients [5].
dc.identifier.citationErsoy, A. (2006). ''Antioxidant treatment in dialysis patients - importance of ferritin''. Nephrology Dialysis Transplantation, 21(7), 2035-2036.,
dc.identifier.endpage2036
dc.identifier.issn0931-0509
dc.identifier.issue7
dc.identifier.pubmed16504978
dc.identifier.scopus2-s2.0-33745607304
dc.identifier.startpage2035
dc.identifier.urihttps://doi.org/10.1093/ndt/gfl050
dc.identifier.urihttps://academic.oup.com/ndt/article/21/7/2035/1821801
dc.identifier.urihttp://hdl.handle.net/11452/21528
dc.identifier.volume21
dc.identifier.wos000238908600063
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherOxford Univ Press
dc.relation.journalNephrology Dialysis Transplantation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTransplantation
dc.subjectUrology & nephrology
dc.subjectSerum ferritin
dc.subjectHemodialysis-patients
dc.subjectOxidative stress
dc.subject.emtreeIron
dc.subject.emtreeFerritin
dc.subject.emtreeAscorbic acid
dc.subject.emtreeApha tocopherol
dc.subject.emtreeVitamin supplementation
dc.subject.emtreeUremia
dc.subject.emtreePriority journal
dc.subject.emtreeOxidative stress
dc.subject.emtreeLipid peroxidation
dc.subject.emtreeLetter
dc.subject.emtreeIron overload
dc.subject.emtreeHuman
dc.subject.emtreeHemodialysis
dc.subject.emtreeFerritin blood level
dc.subject.emtreeDrug megadose
dc.subject.emtreeDisease exacerbation
dc.subject.emtreeDisease association
dc.subject.emtreeCardiovascular risk
dc.subject.emtreeAtherogenesis
dc.subject.emtreeAntioxidant activity
dc.subject.meshRenal dialysis
dc.subject.meshOxidative stress
dc.subject.meshOxidants
dc.subject.meshKidney failure, chronic
dc.subject.meshIron
dc.subject.meshInflammation
dc.subject.meshHumans
dc.subject.meshHemoglobins
dc.subject.meshFerritins
dc.subject.meshAtherosclerosis
dc.subject.meshAscorbic acid
dc.subject.meshAntioxidants
dc.subject.scopusHemodialysis; Ascorbic Acid Deficiency; Chronic Kidney Failure
dc.subject.wosTransplantation
dc.subject.wosUrology & nephrology
dc.titleAntioxidant treatment in dialysis patients - importance of ferritin
dc.typeLetter
dc.wos.quartileQ1 (Urology & nephrology)
dc.wos.quartileQ2 (Transplantation)
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Nefroloji Ana Bilim Dalı
local.indexed.atScopus
local.indexed.atWOS

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