Publication:
Prognostic value of neutrophile-to-lymphocyte ratio (NLR) and lactate dehydrogenase (LDH) levels for geriatric patients with COVID-19

dc.contributor.authorDemirci, Nese
dc.contributor.authorÖzden, Ahmet
dc.contributor.authorErol, Nazlı
dc.contributor.authorIşık, Sema
dc.contributor.authorGulten, Sedat
dc.contributor.authorAtalay, Fatma
dc.contributor.authorCoplu, Nilay
dc.contributor.buuauthorÖNAL, UĞUR
dc.contributor.departmentUludağ Üniversite
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentEnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Ana Bilim Dalı
dc.contributor.orcid0000-0001-6953-8499
dc.contributor.researcheridACQ-7832-2022
dc.date.accessioned2024-09-13T12:49:21Z
dc.date.available2024-09-13T12:49:21Z
dc.date.issued2022-04-25
dc.description.abstractAim In this study it was aimed to evaluate the prognostic factors for the geriatric patients with confirmed COVID-19 in a tertiary-care hospital at Kastamonu region of Turkey. Method Patients (>= 65-year-old) who had PCR positivity for COVID-19 between March 2020 and April 2020 in our center were recorded retrospectively. A p value less than 0.05 was considered significant. Ethical committee approval was given from the Bolu University with decision number 2020/176. Results There were a total of 100 patients (44% female). In-hospital mortality was recorded as 7%. In univariate analysis for 1 month mortality, diabetes mellitus (p = 0.038), leucocyte count (p = 0.005), neutrophile count (p = 0.02), neutrophile-to-lymphocyte ratio (NLR) (p < 0.001), thrombocyte-to-lymphocyte ratio (TLR) (p = 0.001), C-reactive protein (CRP) (p = 0.002), lactate dehydrogenase (LDH) (p = 0.001), sequential organ failure assessment (SOFA) score (p = 0.001) and qSOFA score (p = 0.002) were found as independent risk factors. On admission, one point increase of NLR (p = 0.014, odds ratio (OR) = 1.371, 95% CI = 1.067-1.761) and one point increase of LDH (p = 0.047, OR = 1.011, 95% CI = 1.001-1.023) were associated with mortality on day 30 according to logistic regression analysis. The cut-off values were found as > 7.8 for NLR (83.33% sensitivity, 97.7% specificity) and > 300 U/L for LDH (100% sensitivity, 79.31% specificity) regarding the prediction of 30-day mortality. Conclusion In order to improve clinical management and identify the geriatric patients with COVID-19 who have high risk for mortality, NLR and LDH levels on admission might be useful prognostic tools.
dc.identifier.doi10.1186/s12877-022-03059-7
dc.identifier.issue1
dc.identifier.urihttps://doi.org/10.1186/s12877-022-03059-7
dc.identifier.urihttps://bmcgeriatr.biomedcentral.com/articles/10.1186/s12877-022-03059-7
dc.identifier.urihttps://hdl.handle.net/11452/44733
dc.identifier.volume22
dc.identifier.wos000787289600002
dc.indexed.wosWOS.SCI
dc.indexed.wosWOS.SSCI
dc.language.isoen
dc.publisherBmc
dc.relation.journalBmc Geriatrics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectMortality
dc.subjectSeverity
dc.subjectPredict
dc.subjectPrognostic factors
dc.subjectGeriatric patients
dc.subjectCovid-19
dc.subjectNeutrophile-to-lymphocyte ratio
dc.subjectLactate dehydrogenase
dc.subjectGeriatrics & gerontology
dc.titlePrognostic value of neutrophile-to-lymphocyte ratio (NLR) and lactate dehydrogenase (LDH) levels for geriatric patients with COVID-19
dc.typeArticle
dspace.entity.typePublication
local.contributor.departmentUludağ Üniversite/Tıp Fakültesi/Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Ana Bilim Dalı
relation.isAuthorOfPublication73351d49-e518-4e6a-8f69-c922f8f24611
relation.isAuthorOfPublication.latestForDiscovery73351d49-e518-4e6a-8f69-c922f8f24611

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