Publication: Prognostic value of neutrophile-to-lymphocyte ratio (NLR) and lactate dehydrogenase (LDH) levels for geriatric patients with COVID-19
dc.contributor.author | Demirci, Nese | |
dc.contributor.author | Özden, Ahmet | |
dc.contributor.author | Erol, Nazlı | |
dc.contributor.author | Işık, Sema | |
dc.contributor.author | Gulten, Sedat | |
dc.contributor.author | Atalay, Fatma | |
dc.contributor.author | Coplu, Nilay | |
dc.contributor.buuauthor | ÖNAL, UĞUR | |
dc.contributor.department | Uludağ Üniversite | |
dc.contributor.department | Tıp Fakültesi | |
dc.contributor.department | Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Ana Bilim Dalı | |
dc.contributor.orcid | 0000-0001-6953-8499 | |
dc.contributor.researcherid | ACQ-7832-2022 | |
dc.date.accessioned | 2024-09-13T12:49:21Z | |
dc.date.available | 2024-09-13T12:49:21Z | |
dc.date.issued | 2022-04-25 | |
dc.description.abstract | Aim In this study it was aimed to evaluate the prognostic factors for the geriatric patients with confirmed COVID-19 in a tertiary-care hospital at Kastamonu region of Turkey. Method Patients (>= 65-year-old) who had PCR positivity for COVID-19 between March 2020 and April 2020 in our center were recorded retrospectively. A p value less than 0.05 was considered significant. Ethical committee approval was given from the Bolu University with decision number 2020/176. Results There were a total of 100 patients (44% female). In-hospital mortality was recorded as 7%. In univariate analysis for 1 month mortality, diabetes mellitus (p = 0.038), leucocyte count (p = 0.005), neutrophile count (p = 0.02), neutrophile-to-lymphocyte ratio (NLR) (p < 0.001), thrombocyte-to-lymphocyte ratio (TLR) (p = 0.001), C-reactive protein (CRP) (p = 0.002), lactate dehydrogenase (LDH) (p = 0.001), sequential organ failure assessment (SOFA) score (p = 0.001) and qSOFA score (p = 0.002) were found as independent risk factors. On admission, one point increase of NLR (p = 0.014, odds ratio (OR) = 1.371, 95% CI = 1.067-1.761) and one point increase of LDH (p = 0.047, OR = 1.011, 95% CI = 1.001-1.023) were associated with mortality on day 30 according to logistic regression analysis. The cut-off values were found as > 7.8 for NLR (83.33% sensitivity, 97.7% specificity) and > 300 U/L for LDH (100% sensitivity, 79.31% specificity) regarding the prediction of 30-day mortality. Conclusion In order to improve clinical management and identify the geriatric patients with COVID-19 who have high risk for mortality, NLR and LDH levels on admission might be useful prognostic tools. | |
dc.identifier.doi | 10.1186/s12877-022-03059-7 | |
dc.identifier.issue | 1 | |
dc.identifier.uri | https://doi.org/10.1186/s12877-022-03059-7 | |
dc.identifier.uri | https://bmcgeriatr.biomedcentral.com/articles/10.1186/s12877-022-03059-7 | |
dc.identifier.uri | https://hdl.handle.net/11452/44733 | |
dc.identifier.volume | 22 | |
dc.identifier.wos | 000787289600002 | |
dc.indexed.wos | WOS.SCI | |
dc.indexed.wos | WOS.SSCI | |
dc.language.iso | en | |
dc.publisher | Bmc | |
dc.relation.journal | Bmc Geriatrics | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | Mortality | |
dc.subject | Severity | |
dc.subject | Predict | |
dc.subject | Prognostic factors | |
dc.subject | Geriatric patients | |
dc.subject | Covid-19 | |
dc.subject | Neutrophile-to-lymphocyte ratio | |
dc.subject | Lactate dehydrogenase | |
dc.subject | Geriatrics & gerontology | |
dc.title | Prognostic value of neutrophile-to-lymphocyte ratio (NLR) and lactate dehydrogenase (LDH) levels for geriatric patients with COVID-19 | |
dc.type | Article | |
dspace.entity.type | Publication | |
local.contributor.department | Uludağ Üniversite/Tıp Fakültesi/Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Ana Bilim Dalı | |
relation.isAuthorOfPublication | 73351d49-e518-4e6a-8f69-c922f8f24611 | |
relation.isAuthorOfPublication.latestForDiscovery | 73351d49-e518-4e6a-8f69-c922f8f24611 |