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Birth outcomes in pregnant women with epilepsy: A nationwide multicenter study from Turkiye

dc.contributor.authorPeköz, Mehmet Taylan
dc.contributor.authorAslan-Kara, Kezban
dc.contributor.authorTekin, Betül
dc.contributor.authorGürses, Candan
dc.contributor.authorYeni, Seher Naz
dc.contributor.authorBozdemir, Hacer
dc.contributor.authorKeskin-Güler, Selda
dc.contributor.authorAtaklı, Dilek
dc.contributor.authorGül, Günay
dc.contributor.authorEren, Fulya
dc.contributor.authorSarı, Hüseyin
dc.contributor.authorGül, Zeynep Bastuğ
dc.contributor.authorCeyhan-Dirican, Ayten
dc.contributor.authorGenç, Fatma
dc.contributor.authorBiçer-Gömceli, Yasemin
dc.contributor.authorÖzkara, Ciğdem
dc.contributor.authorDelil, Şakir
dc.contributor.authorAtalar, Arife Çimen
dc.contributor.authorBebek, Nerses
dc.contributor.authorBaykan, Betül
dc.contributor.authorBican-Demir, Aylin
dc.contributor.authorMısırlı Cemile Handan
dc.contributor.authorTutkavul, Kemal
dc.contributor.authorVelioğlu, Sibel K. K.
dc.contributor.authorIlhan-Algın, Demet
dc.contributor.authorErdinç, Oğuz
dc.contributor.authorSaygı, Serap
dc.contributor.authorTezer-Filik, Irsel
dc.contributor.authorApaydın-Doğan, Ebru
dc.contributor.authorAkyol, Ali
dc.contributor.authorKamışlı, Özden
dc.contributor.authorYalçın, A. Destina
dc.contributor.authorÇakmak, Gönül
dc.contributor.authorErsoy, Alevtina
dc.contributor.authorÜstün-Özek, Sibel
dc.contributor.authorHalaç, Gülistan
dc.contributor.authorKutlu, Gülnihal
dc.contributor.authorTantik-Pak, Aygül
dc.contributor.authorYücel, Sevinç P. P.
dc.contributor.buuauthorBora, İbrahim
dc.contributor.buuauthorBORA, İBRAHİM HAKKI
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentNefroloji Ana Bilim Dalı
dc.contributor.researcheridENC-9727-2022
dc.contributor.researcheridENI-7759-2022
dc.date.accessioned2024-12-04T05:55:10Z
dc.date.available2024-12-04T05:55:10Z
dc.date.issued2023-07-14
dc.description.abstractObjectiveThe present study was aimed at investigating the effects of anti-seizure medications (ASMs), patient demographic characteristics, and the seizure type and frequency on the development of congenital malformations (CMs) in the infants of pregnant women with epilepsy (PWWE).MethodsPWWE followed up at the neurology outpatient clinic of 21 centers between 2014 and 2019 were included in this prospective study. The follow-up of PWWE was conducted using structured, general pregnant follow-up forms prepared by the Pregnancy and Epilepsy Study Committee. The newborns were examined by a neonatologist after delivery and at 1 and 3 months postpartum.ResultsOf the infants of 759 PWWE, 7.2% had CMs, with 5.6% having major CMs. Polytherapy, monotherapy, and no medications were received by 168 (22.1%), 548 (72.2 %), and 43 (5.7 %) patients, respectively. CMs were detected at an incidence of 2.3% in infants of PWWE who did not receive medication, 5.7% in infants of PWWE who received monotherapy, and 13.7% in infants of PWWE who received polytherapy. The risk of malformation was 2.31-fold (95% confidence interval (CI): 1.48-4.61, p < .001) higher in infants of PWWE who received polytherapy. Levetiracetam was the most frequently used seizure medication as monotherapy, with the highest incidence of CMs occurring with valproic acid (VPA) use (8.5%) and the lowest with lamotrigine use (2.1%). The incidence of CMs was 5% at a carbamazepine dose <700 mg, 10% at a carbamazepine dose & GE;700 mg, 5.5% at a VPA dose <750 mg, and 14.8% at a VPA dose =750 mg. Thus the risk of malformation increased 2.33 times (p = .041) in infants of PWWE receiving high-dose ASMs.SignificanceBirth outcomes of PWWE receiving and not receiving ASMs were evaluated. The risk of CMs occurrence was higher, particularly in infants of PWWE using VPA and receiving polytherapy. The incidence of CMs was found to be lower in infants of PWWE receiving lamotrigine.
dc.identifier.doi10.1111/epi.17692
dc.identifier.endpage2321
dc.identifier.issn0013-9580
dc.identifier.issue9
dc.identifier.startpage2310
dc.identifier.urihttps://doi.org/10.1111/epi.17692
dc.identifier.urihttps://hdl.handle.net/11452/48854
dc.identifier.volume64
dc.identifier.wos001029932900001
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherWiley
dc.relation.journalEpilepsia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectMajor congenital-malformations
dc.subjectAntiepileptic drugs
dc.subjectRisk
dc.subjectRegistry
dc.subjectPrevalence
dc.subjectExposure
dc.subjectEurap
dc.subjectDefects
dc.subjectAutism
dc.subjectAcid
dc.subjectAnti-seizure medications
dc.subjectCongenital malformation
dc.subjectPregnant women with epilepsy
dc.subjectTeratogenicity
dc.subjectScience & technology
dc.subjectLife sciences & biomedicine
dc.subjectClinical neurology
dc.subjectNeurosciences & neurology
dc.titleBirth outcomes in pregnant women with epilepsy: A nationwide multicenter study from Turkiye
dc.typeArticle
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Nefroloji Ana Bilim Dalı
relation.isAuthorOfPublication7674bbf4-9c63-42a4-b1e0-09ecdcb8f05a
relation.isAuthorOfPublication.latestForDiscovery7674bbf4-9c63-42a4-b1e0-09ecdcb8f05a

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