Publication:
Central injection of captopril inhibits the blood pressure response to intracerebroventricular choline

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dc.contributor.buuauthorİsbil, Naciye Büyükcoşkun
dc.contributor.buuauthorÖzlük, Kasım
dc.contributor.buuauthorUlus, İsmail Hakkı
dc.contributor.buuauthorGüleç, Gamze Gül
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentPsikiyatri Bölümü
dc.contributor.departmentFarmakoloji Ana Bilim Dalı
dc.contributor.researcheridD-5340-2015
dc.contributor.researcheridAAH-1692-2021
dc.contributor.scopusid55665951400
dc.contributor.scopusid6602752303
dc.contributor.scopusid6602676331
dc.contributor.scopusid7004271086
dc.date.accessioned2022-01-05T07:07:17Z
dc.date.available2022-01-05T07:07:17Z
dc.date.issued2001-06
dc.description.abstractIn the present study, we investigated the involvement of the brain renin-angiotensin system in the effects of central cholinergic stimulation on blood pressure in conscious, freely moving normotensive rats. In the first step, we determined the effects of intracerebroventricular (icv) choline (50, 100 and 150 μg) on blood pressure. Choline increased blood pressure in a dose-dependent manner. In order to investigate the effects of brain renin-angiotensin system blockade on blood pressure increase induced by choline (150 μg, icv), an angiotensin-converting enzyme inhibitor, captopril (25 and 50 μg, icv), was administered 3 rain before choline. Twenty-five μg captopril did not block the pressor effect of choline, while 50 μg captopril blocked it significantly. Our results suggest that the central renin-angiotensin system may participate in the increase in blood pressure induced by icv choline in normotensive rats.
dc.identifier.citationİşbil, B. N. vd. (2001). "Central injection of captopril inhibits the blood pressure response to intracerebroventricular choline". Brazilian Journal of Medical and Biological Research, 34(6), 815-820.
dc.identifier.endpage820
dc.identifier.issn0100-879X
dc.identifier.issue6
dc.identifier.pubmed11378673
dc.identifier.scopus2-s2.0-0034952686
dc.identifier.startpage815
dc.identifier.urihttps://doi.org/10.1590/S0100-879X2001000600018
dc.identifier.urihttps://www.scielo.br/j/bjmbr/a/B7ZmggtDxTPVYkTQVTkZqCh/?lang=en
dc.identifier.urihttp://hdl.handle.net/11452/23858
dc.identifier.volume34
dc.identifier.wos000169443400018
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherAssoc Bras Divulg Cientifica
dc.relation.journalBrazilian Journal of Medical and Biological Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBlood pressure
dc.subjectCaptopril
dc.subjectCholine
dc.subjectIntracerebroventricular choline
dc.subjectSpontaneously hypertensive rats
dc.subjectRenin-angiotensin system
dc.subjectConscious rabbits
dc.subjectNormotensive rats
dc.subjectBrain
dc.subjectHemorrhage
dc.subjectStimulation
dc.subjectCarbachol
dc.subjectDrinking
dc.subjectLife sciences & biomedicine - other topics
dc.subjectResearch & experimental medicine
dc.subject.emtreeAngiotensin
dc.subject.emtreeDipeptidyl carboxypeptidase inhibitor
dc.subject.emtreeAnimal model
dc.subject.emtreeCaptopril
dc.subject.emtreeRenin angiotensin aldosterone system
dc.subject.emtreeDose response
dc.subject.emtreeAnimal experiment
dc.subject.emtreeCholine
dc.subject.emtreeLosartan
dc.subject.emtreeBlood pressure regulation
dc.subject.emtreeRamipril
dc.subject.emtreeArticle
dc.subject.emtreeRessure
dc.subject.emtreeCholinergic stimulation
dc.subject.emtreeControlled study
dc.subject.emtreeMale
dc.subject.emtreeNonhuman
dc.subject.emtreeRat
dc.subject.scopusPregnanolone; Orexins; Scotophase
dc.subject.wosBiology
dc.subject.wosMedicine, research & experimental
dc.titleCentral injection of captopril inhibits the blood pressure response to intracerebroventricular choline
dc.typeArticle
dc.wos.quartileQ3
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Psikiyatri Bölümü
local.contributor.departmentTıp Fakültesi/Farmakoloji Ana Bilim Dalı
local.indexed.atScopus
local.indexed.atWOS

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