Publication:
Testicular adrenal rest tumors in patients with congenital adrenal hyperplasia

dc.contributor.buuauthorÇakır, Esra Deniz Papatya
dc.contributor.buuauthorMutlu, Fatma Şentürk
dc.contributor.buuauthorEren, Erdal
dc.contributor.buuauthorPaşa, Aliye Özlem
dc.contributor.buuauthorSağlam, Halil
dc.contributor.buuauthorTarım, Ömer
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentRadyoloji Ana Bilim Dalı
dc.contributor.departmentÇocuk Endokrinoloji Ana Bilim Dalı
dc.contributor.orcid0000-0003-0710-5422
dc.contributor.orcid0000-0002-1684-1053
dc.contributor.researcheridC-7392-2019
dc.contributor.researcheridAAM-1734-2020
dc.contributor.researcheridAAH-1155-2021
dc.contributor.scopusid37003613900
dc.contributor.scopusid48061357900
dc.contributor.scopusid36113153400
dc.contributor.scopusid55270612300
dc.contributor.scopusid35612700100
dc.contributor.scopusid6701427186
dc.date.accessioned2021-11-24T09:45:22Z
dc.date.available2021-11-24T09:45:22Z
dc.date.issued2012
dc.description.abstractObjective: Early diagnosis and treatment of testicular adrenal rest tumors (TART) is important for gonadal functions and fertility protection in boys with congenital adrenal hyperplasia (CAH). In this descriptive study, we investigated the prevalence of TART in boys with 21-hydroxylase deficient (21OHD) CAH followed in our pediatric endocrine clinic. Methods: The study group consisted of 14 male patients with a mean age of 9.6+/-5.1 (range: 0.8-18.3) years. Six (42.9%) of the 14 patients were diagnosed as having salt-wasting type (SW) and eight (57.1%) patients - as having the simple virilizing (SV) form of 21OHD. Mean age at diagnosis was 2.9+/-2.7 (range: 0.03-6.3) years. Two different radiologists performed scrotal ultrasonography. Chronological age, bone age, and anthropometric measurements were evaluated. Serum adrenocorticotropic hormone (ACTH), 17-alpha-hydroxyprogesterone (17OHP) and androstenedione levels were also evaluated in all patients during the follow-up period. Results: Scrotal ultrasonography revealed bilateral TART in two patients (14.3%) and testicular microlithiasis (TM) in four patients (28.6%). One patient had both TART and TM bilaterally. During the follow-up period, the mean serum adrenocorticotropic hormone, 17OHP and androstenedione levels in the total group of patients were 130.0+/-179.1 pg/mL (21.7-726.5), 5.8+/-3.3 ng/mL (0.8-11.4) and 4.3+/-4.1 (0.2-11.0) ng/mL, respectively. Conclusions: Microlithiasis or TART may be frequently encountered during the follow-up of patients with CAH. In order to prevent late complications including infertility, we suggest that ultrasonographic evaluations be performed yearly in all male CAH patients.
dc.identifier.citationÇakır, E. D. P. vd. (2012). "Testicular adrenal rest tumors in patients with congenital adrenal hyperplasia". Journal of Clinical Research in Pediatric Endocrinology, 4(2), 94-100.
dc.identifier.endpage100
dc.identifier.issn1308-5727
dc.identifier.issn1308-5735
dc.identifier.issue2
dc.identifier.pubmed22672867
dc.identifier.scopus2-s2.0-84863113855
dc.identifier.startpage94
dc.identifier.urihttps://doi.org/10.4274/jcrpe.563
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/22672867/
dc.identifier.urihttp://hdl.handle.net/11452/22785
dc.identifier.volume4
dc.identifier.wos000209012600008
dc.indexed.wosSCIE
dc.indexed.wosBKCIS
dc.language.isoen
dc.publisherGalenos Yayıncılık
dc.relation.journalJournal of Clinical Research in Pediatric Endocrinology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectEndocrinology & metabolism
dc.subjectPediatrics
dc.subjectTesticular adrenal rest tumors
dc.subjectTesticular microlithiasis
dc.subjectCongenital adrenal hyperplasia
dc.subject.emtreeAndrostenedione
dc.subject.emtreeCorticotropin
dc.subject.emtreeCyproterone acetate
dc.subject.emtreeFludrocortisone
dc.subject.emtreeGlucocorticoid
dc.subject.emtreeGrowth hormone
dc.subject.emtreeHydrocortisone
dc.subject.emtreeHydroxyprogesterone
dc.subject.emtreeLeuprorelin
dc.subject.emtreeTamoxifen
dc.subject.emtreeAdolescent
dc.subject.emtreeAdrenal cortex tumor
dc.subject.emtreeAdult
dc.subject.emtreeAge
dc.subject.emtreeAndrostenedione blood level
dc.subject.emtreeAnthropometry
dc.subject.emtreeArticle
dc.subject.emtreeBone age
dc.subject.emtreeCancer patient
dc.subject.emtreeChild
dc.subject.emtreeClinical article
dc.subject.emtreeClinical evaluation
dc.subject.emtreeCongenital adrenal hyperplasia
dc.subject.emtreeControlled study
dc.subject.emtreeDescriptive research
dc.subject.emtreeEchography
dc.subject.emtreeFollow up
dc.subject.emtreeGynecomastia
dc.subject.emtreeHormone blood level
dc.subject.emtreeHuman
dc.subject.emtreeInfant
dc.subject.emtreeInfertility
dc.subject.emtreeMale
dc.subject.emtreePreschool child
dc.subject.emtreePrevalence
dc.subject.emtreeRadiologist
dc.subject.emtreeSalt wasting
dc.subject.emtreeSchool child
dc.subject.emtreeSteroid 21 monooxygenase deficiency
dc.subject.emtreeTestis tumor
dc.subject.emtreeTumor diagnosis
dc.subject.emtreeVirilization
dc.subject.mesh17-alpha-hydroxyprogesterone
dc.subject.meshAdolescent
dc.subject.meshAdrenal hyperplasia, congenital
dc.subject.meshAdrenal rest tumor
dc.subject.meshAdrenocorticotropic hormone
dc.subject.meshAge determination by skeleton
dc.subject.meshAndrostenedione
dc.subject.meshChild
dc.subject.meshChild, preschool
dc.subject.meshFollow-up studies
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshScrotum
dc.subject.meshSteroid 21-hydroxylase
dc.subject.meshTesticular neoplasms
dc.subject.meshTreatment outcome
dc.subject.meshUltrasonography
dc.subject.scopusAdrenal Cortex Tumor; Congenital Adrenal Hyperplasia; Testicular Neoplasms
dc.subject.wosEndocrinology & metabolism
dc.subject.wosPediatrics
dc.titleTesticular adrenal rest tumors in patients with congenital adrenal hyperplasia
dc.typeArticle
dc.typeBook Chapter
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Çocuk Endokrinoloji Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Radyoloji Ana Bilim Dalı
local.indexed.atScopus
local.indexed.atWOS

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