Publication:
Evaluation of Nigella sativa oil loaded electrospun polyurethane nanofibrous mat as wound dressing

dc.contributor.authorAras, Cansu
dc.contributor.authorÖzer, Elif Tümay
dc.contributor.authorGöktalay, Gökhan
dc.contributor.authorSaat, Gülbahar
dc.contributor.authorKaraca, Esra
dc.contributor.buuauthorARAS GÜL, CANSU
dc.contributor.buuauthorTÜMAY ÖZER, ELİF
dc.contributor.buuauthorGÖKTALAY, GÖKHAN
dc.contributor.buuauthorKARACA, ESRA
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentFarmakoloji Ana Bilim Dalı
dc.contributor.orcid0000-0003-1777-3977
dc.contributor.researcheridAAI-3137-2021
dc.contributor.researcheridAAS-8480-2020
dc.contributor.researcheridEKA-8835-2022
dc.contributor.researcheridAAI-3137-2021
dc.contributor.researcheridJKY-1522-2023
dc.contributor.researcheridDPL-6507-2022
dc.date.accessioned2024-06-10T10:04:14Z
dc.date.available2024-06-10T10:04:14Z
dc.date.issued2021-06-02
dc.description.abstractElectrospun nanofibers have a natural wound healing effect due to their similarity to the extracellular matrix (ECM). Nigella sativa oil, which has therapeutic properties, is used for a wide variety of applications in traditional medicine. The aim of this study was to investigate the release characteristic and wound healing performance of Nigella sativa oil (NSO) loaded polyurethane (PU) electrospun nanofibrous mats in wound dressing applications. In addition, the antibacterial activity and cytotoxicity of the electrospun mats were studied. Analyses using a scanning electron microscope (SEM) showed that PU/NSO nanofibrous mat with an average fiber diameter of 416 +/- 66 nm were successfully fabricated. NSO was released at a maximum ratio of 30% from the electrospun mat, and the Korsmeyer-Peppas model was identified as best for determining the release mechanism. Significant antibacterial activity was observed against Staphylococcus aureus (90.26%) and Escherichia coli (95.75%). The developed PU/NSO nanofibrous mat increased the cell viability more than 100% in human umbilical vein endothelial cell line (HUVEC) cell line. The NSO loaded PU nanofibrous mat significantly promoted the wound healing process on a rat wound model, and its wound closure reached approximately 85% compared to the control groups on the 9(th) day (p < 0.01). The results indicated PU/NSO nanofibrous mat is a suitable candidate for a wound dressing.
dc.identifier.doi10.1080/09205063.2021.1937463
dc.identifier.eissn1568-5624
dc.identifier.endpage1735
dc.identifier.issn0920-5063
dc.identifier.issue13
dc.identifier.startpage1718
dc.identifier.urihttps://doi.org/10.1080/09205063.2021.1937463
dc.identifier.urihttps://www.tandfonline.com/doi/full/10.1080/09205063.2021.1937463
dc.identifier.urihttps://hdl.handle.net/11452/41922
dc.identifier.volume32
dc.identifier.wos000673483400001
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherTaylor
dc.relation.journalJournal of Biomaterials Science-polymer Edition
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectDrug-delivery
dc.subjectTherapeutic agents
dc.subjectPolymer nanofibers
dc.subjectActive principle
dc.subjectRelease systems
dc.subjectThymoquinone
dc.subjectNigella sativa oil
dc.subjectPolyurethane
dc.subjectNanofiber
dc.subjectWound dressing
dc.subjectRelease
dc.subjectWound healing
dc.subjectScience & technology
dc.subjectTechnology
dc.subjectPhysical sciences
dc.subjectEngineering, biomedical
dc.subjectMaterials science, biomaterials
dc.subjectPolymer science
dc.subjectEngineering
dc.subjectMaterials science
dc.titleEvaluation of Nigella sativa oil loaded electrospun polyurethane nanofibrous mat as wound dressing
dc.typeArticle
dspace.entity.typePublication
local.contributor.departmentMühendislik Fakültesi/Tekstil Bölümü
local.contributor.departmentFen Edebiyat Fakültesi/Kimya Bölümü
local.contributor.departmentTıp Fakültesi/Farmakoloji Ana Bilim Dalı
relation.isAuthorOfPublication140d0426-4f10-41da-9718-9d082e57c943
relation.isAuthorOfPublication7b3ec35a-e96e-4664-8c05-e423a7662a1a
relation.isAuthorOfPublicationc134bdf1-13f0-4729-829d-1f6b6b68d435
relation.isAuthorOfPublication4ece70c9-8b96-4a7f-a755-25022ef3b32d
relation.isAuthorOfPublication.latestForDiscovery140d0426-4f10-41da-9718-9d082e57c943

Files