Publication:
Postmenopausal estrogen receptor positive breast cancer and obesity associated gene variants

dc.contributor.authorÖzgöz, Asuman
dc.contributor.authorİçduygu, Fadime Mutlu
dc.contributor.authorYükseltürk, Ayşegül
dc.contributor.authorÖztürk, Kuyas Hekimler
dc.contributor.authorBaşkan, Zuhal
dc.contributor.authorTütüncü, İlknur
dc.contributor.buuauthorŞamlı, Hale
dc.contributor.departmentVeteriner Fakültesi
dc.contributor.departmentGenetik Ana Bilim Dalı
dc.contributor.orcid0000-0003-4728-0735
dc.contributor.researcheridFVW-7687-2022
dc.contributor.scopusid6507670789
dc.date.accessioned2024-01-11T13:20:04Z
dc.date.available2024-01-11T13:20:04Z
dc.date.issued2021
dc.description.abstractObesity is one of the most important health risks in postmenopausal women. Molecular pathways that are connected with obesity are believed to interact with the pathogenesis of breast cancer (BC). The aim of this research was to study the polymorphisms of two obesity-associated genes ADIPOQ and FTO that are also related to the pathogenesis of BC. Obesity-associated gene polymorphisms ADIPOQ rs1501299 and rs2241766, and FTO rs1477196, rs7206790, rs8047395, and rs9939609 were studied in 101 Turkish postmenopausal estrogen receptor-positive BC patients and 100 healthy control individuals. ADIPOQ rs1501299 was detected to be associated with protection against BC. The ADIPOQ rs1501299 TT genotype, the rs2241766 GT genotype and the G allele were found to be significantly higher in the control group. In addition, ADIPOQ rs1501299 polymorphism was protective in the recessive model and rs2241766 polymorphism was protective in the dominant model. While none of the FTO gene polymorphisms were found to be associated with BC, the frequencies of rs9939609 A allele and rs7206790 G allele were correlated with body mass index (BMI) in BC patients. ADIPOQ rs1501299 TT genotype, rs2241766 GT genotype, and G allele might be protective against BC in the Turkish population but this conclusion needs to be further verified.
dc.description.sponsorshipKastamonu Üniversitesi Bilimsel Araştırma Projeleri Yönetim Koordinatörlüğü - KUBAP-01/2013-30
dc.identifier.citationÖzgöz, A. vd. (2021). "Postmenopausal estrogen receptor positive breast cancer and obesity associated gene variants". EXCLI Journal, 20, 1133-1144.
dc.identifier.doihttps://doi.org/10.17179/excli2020-2860
dc.identifier.endpage1144
dc.identifier.issn1611-2156
dc.identifier.pubmed34345232
dc.identifier.scopus2-s2.0-85111114064
dc.identifier.startpage1133
dc.identifier.urihttps://www.excli.de/index.php/excli/article/view/2860
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8326496/
dc.identifier.urihttps://hdl.handle.net/11452/38970
dc.identifier.volume20
dc.identifier.wos000669494900001
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherEXCLI
dc.relation.collaborationYurt içi
dc.relation.collaborationSanayi
dc.relation.journalEXCLI Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectADIPOQ
dc.subjectFTO
dc.subjectPolymorphism
dc.subjectPostmenopausal
dc.subjectBreast cancer
dc.subjectAdiponectin
dc.subjectLevels
dc.subjectRisk
dc.subjectPolymorphisms
dc.subjectSusceptibility
dc.subjectAdipoq
dc.subjectWomen
dc.subjectPredictors
dc.subjectLeptin
dc.subjectLEPR
dc.subjectLife sciences & biomedicine-other topics
dc.subject.emtreeEstrogen receptor
dc.subject.emtreeAdipoq gene
dc.subject.emtreeAdult
dc.subject.emtreeAllele
dc.subject.emtreeArticle
dc.subject.emtreeBody mass
dc.subject.emtreeCancer grading
dc.subject.emtreeControlled study
dc.subject.emtreeEstrogen receptor positive breast cancer
dc.subject.emtreeFamily history
dc.subject.emtreeFemale
dc.subject.emtreeFto gene
dc.subject.emtreeGene function
dc.subject.emtreeGene identification
dc.subject.emtreeGenetic polymorphism
dc.subject.emtreeGenetic variability
dc.subject.emtreeGenotype
dc.subject.emtreeHuman
dc.subject.emtreeMajor clinical study
dc.subject.emtreeMatrix assisted laser desorption ionization time of flight mass spectrometry
dc.subject.emtreeObesity
dc.subject.emtreePathogenesis
dc.subject.emtreePostmenopause
dc.subject.emtreeSmoking habit
dc.subject.emtreeTumor gene
dc.subject.emtreeTumor volume
dc.subject.scopusLeptin Receptors; Adiponectin; Obesity
dc.subject.wosBiology
dc.titlePostmenopausal estrogen receptor positive breast cancer and obesity associated gene variants
dc.typeArticle
dc.wos.quartileQ2 (Biology)
dc.wos.quartileQ1 (Biology)
dspace.entity.typePublication
local.contributor.departmentVeteriner Fakültesi/Genetik Ana Bilim Dalı
local.indexed.atWOS
local.indexed.atScopus

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