Publication:
Behçet disease with vascular involvement: Effects of different therapeutic regimens on the incidence of new relapses

dc.contributor.authorÖner, Fatma Alibaz
dc.contributor.authorKaradeniz, Aslı
dc.contributor.authorYılmaz, Sema
dc.contributor.authorBalkarlı, Ayşe
dc.contributor.authorKimyon, Gezmiş
dc.contributor.authorYazıcı, Ayten
dc.contributor.authorÇınar, Muhammet
dc.contributor.authorYılmaz, Sedat
dc.contributor.authorYıldız, Fatih
dc.contributor.authorBilge, Şule Yaşar
dc.contributor.authorBilgin, Emre
dc.contributor.authorOmma, Ahmet
dc.contributor.authorÇetin, Gözde Yıldırım
dc.contributor.authorÇağatay, Yonca
dc.contributor.authorKaraaslan, Yaşar
dc.contributor.authorSayarlıoğlu, Mehmet
dc.contributor.authorKalyoncu, Umut
dc.contributor.authorKaradağ, Ömer
dc.contributor.authorKaşifoğlu, Timuçin
dc.contributor.authorErken, Eren
dc.contributor.authorPay, Salih
dc.contributor.authorÇefle, Ayşe
dc.contributor.authorKısacık, Bünyamin
dc.contributor.authorOnat, Ahmet Mesut
dc.contributor.authorÇobankara, Veli
dc.contributor.authorDireskeneli, Haner
dc.contributor.buuauthorCoşkun, Belkıs Nihan
dc.contributor.buuauthorPehlivan, Yavuz
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentRomatoloji Ana Bilim Dalı
dc.contributor.orcid0000-0003-0298-4157
dc.contributor.researcheridAAG-7155-2021
dc.contributor.researcheridAAG-8227-2021
dc.contributor.scopusid55646165400
dc.contributor.scopusid13205593600
dc.date.accessioned2022-06-09T07:19:44Z
dc.date.available2022-06-09T07:19:44Z
dc.date.issued2015-02
dc.description.abstractVascular involvement is one of the major causes of mortality and morbidity in Behcet disease (BD). There are no controlled studies for the management of vascular BD (VBD), and according to the EULAR recommendations, only immunosuppressive (IS) agents are recommended. In this study, we aimed to investigate the therapeutic approaches chosen by Turkish physicians during the initial event and relapses of VBD and the association of different treatment options with the relapses retrospectively. Patients with BD (n = 936, female/male: 347/589, mean age: 37.6 +/- 10.8) classified according to ISG criteria from 15 rheumatology centers in Turkey were included. The demographic data, clinical characteristics of the first vascular event and relapses, treatment protocols, and data about complications were acquired. VBD was observed in 27.7% (n = 260) of the patients during follow-up. In 57.3% of the VBD patients, vascular involvement was the presenting sign of the disease. After the first vascular event, ISs were given to 88.8% and AC treatment to 59.8% of the patients. Median duration of AC treatment was 13 months (1-204) and ISs, 22 months (1-204). Minor hemorrhage related to AC treatment was observed in 7 (4.7%) patients. Asecond vascular event developed in 32.9% (n = 86) of the patients. The vascular relapse rate was similar between patients taking only ISs and AC plus IS treatments after the first vascular event (29.1% vs 22.4%, P = 0.28) and was significantly higher in group taking only ACs than taking only ISs (91.6% vs 29.1%, P < 0.001). During follow-up, a third vascular event developed in 17 (n = 6.5%) patients. The relapse rate was also similar between the patients taking only ISs and AC plus IS treatments after second vascular event (25.3% vs 20.8%, P = 0.93). When multivariate analysis was performed, development of vascular relapse negatively correlated with only IS treatments. We did not find any additional positive effect of AC treatment used in combination with ISs in the course of vascular involvement in patients with BD. Severe complications related to AC treatment were also not detected. Our results suggest that short duration of IS treatments and compliance issues of treatment are the major problems in VBD associated with vascular relapses during follow-up.
dc.identifier.citationÖner, F. A. vd. (2015). "Behçet disease with vascular involvement: Effects of different therapeutic regimens on the incidence of new relapses". Medicine, 94(6).
dc.identifier.issn0025-7974
dc.identifier.issue6
dc.identifier.pubmed25674739
dc.identifier.scopus2-s2.0-84926480623
dc.identifier.urihttps://doi.org/10.1097/MD.0000000000000494
dc.identifier.urihttps://journals.lww.com/md-journal/Fulltext/2015/02020/Beh_et_Disease_With_Vascular_Involvement__Effects.10.aspx
dc.identifier.urihttp://hdl.handle.net/11452/26996
dc.identifier.volume94
dc.identifier.wos000349772200012
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherLippincott Williams & Wilkins
dc.relation.collaborationYurt içi
dc.relation.collaborationSanayi
dc.relation.journalMedicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectThrombosis
dc.subjectMortality
dc.subjectGeneral & internal medicine
dc.subject.emtreeAlpha interferon
dc.subject.emtreeAnticoagulant agent
dc.subject.emtreeAzathioprine
dc.subject.emtreeCorticosteroid
dc.subject.emtreeCyclophosphamide
dc.subject.emtreeImmunosuppressive agent
dc.subject.emtreeInfliximab
dc.subject.emtreeLow molecular weight heparin
dc.subject.emtreeMethotrexate
dc.subject.emtreeWarfarin
dc.subject.emtreeAdult
dc.subject.emtreeAnticoagulant therapy
dc.subject.emtreeArticle
dc.subject.emtreeBehcet disease
dc.subject.emtreeBleeding
dc.subject.emtreeClinical feature
dc.subject.emtreeDemography
dc.subject.emtreeEpistaxis
dc.subject.emtreeFemale
dc.subject.emtreeFollow up
dc.subject.emtreeGastrointestinal hemorrhage
dc.subject.emtreeHematoma
dc.subject.emtreeHuman
dc.subject.emtreeImmunosuppressive treatment
dc.subject.emtreeMajor clinical study
dc.subject.emtreeMale
dc.subject.emtreePhysician
dc.subject.emtreePriority journal
dc.subject.emtreeRecurrence risk
dc.subject.emtreeRelapse
dc.subject.emtreeRetrospective study
dc.subject.emtreeTreatment duration
dc.subject.emtreeVascular Behcet disease
dc.subject.emtreeVascular disease
dc.subject.emtreeBehcet Syndrome
dc.subject.emtreePathology
dc.subject.emtreeRecurrent disease
dc.subject.emtreeVasculitis
dc.subject.meshAdult
dc.subject.meshBehcet Syndrome
dc.subject.meshFemale
dc.subject.meshFollow-up studies
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshRecurrence
dc.subject.meshRetrospective studies
dc.subject.meshVasculitis
dc.subject.scopusBehcet Syndrome; False Aneurysm; Case Report
dc.subject.wosMedicine, general & internal
dc.titleBehçet disease with vascular involvement: Effects of different therapeutic regimens on the incidence of new relapses
dc.typeArticle
dc.wos.quartileQ2
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Romatoloji Ana Bilim Dalı
local.indexed.atScopus
local.indexed.atWOS

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