Publication:
Genome-wide association mapping for identification of quantitative trait loci for rectal temperature during heat stress in holstein cattle

dc.contributor.authorCole, John B.
dc.contributor.authorNull, Daniel J.
dc.contributor.authorHansen, Peter J.
dc.contributor.buuauthorDikmen, Serdal
dc.contributor.departmentVeterinerlik Fakültesi
dc.contributor.departmentHayvan Bilimleri Ana Bilim Dalı
dc.contributor.orcid0000-0002-5611-4993
dc.contributor.researcheridA-5731-2018
dc.contributor.scopusid8280302600
dc.date.accessioned2022-10-06T08:12:37Z
dc.date.available2022-10-06T08:12:37Z
dc.date.issued2013-07-23
dc.description.abstractHeat stress compromises production, fertility, and health of dairy cattle. One mitigation strategy is to select individuals that are genetically resistant to heat stress. Most of the negative effects of heat stress on animal performance are a consequence of either physiological adaptations to regulate body temperature or adverse consequences of failure to regulate body temperature. Thus, selection for regulation of body temperature during heat stress could increase thermotolerance. The objective was to perform a genome-wide association study (GWAS) for rectal temperature (RT) during heat stress in lactating Holstein cows and identify SNPs associated with genes that have large effects on RT. Records on afternoon RT where the temperature-humidity index was >= 78.2 were obtained from 4,447 cows sired by 220 bulls, resulting in 1,440 useable genotypes from the Illumina BovineSNP50 BeadChip with 39,759 SNP. For GWAS, 2, 3, 4, 5, and 10 adjacent SNP were averaged to identify consensus genomic regions associated with RT. The largest proportion of SNP variance (0.07 to 0.44%) was explained by markers flanking the region between 28,877,547 and 28,907,154 bp on Bos taurus autosome (BTA) 24. That region is flanked by U1 (28,822,883 to 28,823,043) and NCAD (28,992,666 to 29,241,119). In addition, the SNP at 58,500,249 bp on BTA 16 explained 0.08% and 0.11% of the SNP variance for 2- and 3-SNP analyses, respectively. That contig includes SNORA19, RFWD2 and SCARNA3. Other SNPs associated with RT were located on BTA 16 (close to CEP170 and PLD5), BTA 5 (near SLCO1C1 and PDE3A), BTA 4 (near KBTBD2 and LSM5), and BTA 26 (located in GOT1, a gene implicated in protection from cellular stress). In conclusion, there are QTL for RT in heat-stressed dairy cattle. These SNPs could prove useful in genetic selection and for identification of genes involved in physiological responses to heat stress.
dc.description.sponsorshipUnited States Department of Agriculture (USDA) (2010-85122-20623)
dc.description.sponsorshipUnited States Department of Agriculture (USDA) (2013-68004-20365)
dc.description.sponsorshipSoutheast Dairy Inc. Milk Checkoff Program
dc.identifier.citationDikmen, S. vd. (2013). "Genome-wide association mapping for identification of quantitative trait loci for rectal temperature during heat stress in holstein cattle". Plos One, 8(7).
dc.identifier.issn1932-6203
dc.identifier.issue7
dc.identifier.pubmed23935954
dc.identifier.scopus2-s2.0-84880724183
dc.identifier.urihttps://doi.org/10.1371/journal.pone.0069202
dc.identifier.urihttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0069202
dc.identifier.urihttp://hdl.handle.net/11452/28995
dc.identifier.volume8
dc.identifier.wos000325211000089
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherPublic Library Science
dc.relation.collaborationSanayi
dc.relation.collaborationYurt dışı
dc.relation.journalPlos One
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectScience & technology - other topics
dc.subjectFull pedigree
dc.subjectGenetic evaluation
dc.subjectDairy-cows
dc.subjectTolerance
dc.subjectReproduction
dc.subjectProteins
dc.subjectLength
dc.subject.emtreeContig
dc.subject.emtreeArticle
dc.subject.emtreeAutosome
dc.subject.emtreeCEP170 gene
dc.subject.emtreeCow
dc.subject.emtreeFemale
dc.subject.emtreeGene
dc.subject.emtreeGenetic association
dc.subject.emtreeGenotype
dc.subject.emtreeGot1 gene
dc.subject.emtreeHeat stress
dc.subject.emtreeHumidity
dc.subject.emtreeKBTBD2 gene
dc.subject.emtreeLactation
dc.subject.emtreeLSM5 gene
dc.subject.emtreeNCAD gene
dc.subject.emtreeNonhuman
dc.subject.emtreePDE3A gene
dc.subject.emtreePLD5 gene
dc.subject.emtreeQuantitative trait locus mapping
dc.subject.emtreeRectum temperature
dc.subject.emtreeRFWD2 gene
dc.subject.emtreeSCARNA3 gene
dc.subject.emtreeSingle nucleotide polymorphism
dc.subject.emtreeSLCO1C1 gene
dc.subject.emtreeSNORA19 gene
dc.subject.emtreeU1 gene
dc.subject.emtreeAnimal
dc.subject.emtreeBody temperature
dc.subject.emtreeCattle
dc.subject.emtreeChromosome map
dc.subject.emtreeGene locus
dc.subject.emtreeGenetics
dc.subject.emtreeHeat shock response
dc.subject.emtreePathophysiology
dc.subject.emtreeQuantitative trait locus
dc.subject.emtreeRectum
dc.subject.emtreeBody temperature
dc.subject.emtreeBovinae
dc.subject.meshAnimals
dc.subject.meshBody temperature
dc.subject.meshCattle
dc.subject.meshChromosome mapping
dc.subject.meshGenetic loci
dc.subject.meshGenome-wide association study
dc.subject.meshHeat-shock response
dc.subject.meshPolymorphism, single nucleotide
dc.subject.meshQuantitative trait loci
dc.subject.meshRectum
dc.subject.scopusDairy Cows; Holstein-Friesian Cattle; Cattle
dc.subject.wosMultidisciplinary sciences
dc.titleGenome-wide association mapping for identification of quantitative trait loci for rectal temperature during heat stress in holstein cattle
dc.typeArticle
dc.wos.quartileQ1
dspace.entity.typePublication
local.contributor.departmentVeterinerlik Fakültesi/Hayvan Bilimleri Ana Bilim Dalı
local.indexed.atScopus
local.indexed.atWOS

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