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Parmelia sulcata Taylor and Usnea filipendula Stirt induce apoptosis-like cell death and DNA damage in cancer cells

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dc.contributor.buuauthorArı, Ferda
dc.contributor.buuauthorAztopal, Nazlıhan
dc.contributor.buuauthorOran, Seyhan
dc.contributor.buuauthorBozdemir, Şefika
dc.contributor.buuauthorÇelikler, Serap
dc.contributor.buuauthorÖztürk, Şule
dc.contributor.buuauthorUlukaya, Engin
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentFen Edebiyat Fakültesi
dc.contributor.departmentBiyoloji Bölümü
dc.contributor.departmentBiyokimya Ana Bilim Dalı
dc.contributor.orcid0000-0002-6729-7908
dc.contributor.orcid0000-0001-8196-2065
dc.contributor.orcid0000-0002-4177-3478
dc.contributor.orcid0000-0003-3118-8061
dc.contributor.researcheridAAG-7012-2021
dc.contributor.researcheridAAD-7322-2019
dc.contributor.researcheridAAH-5039-2021
dc.contributor.researcheridK-5792-2018
dc.contributor.researcheridAAH-2767-2021
dc.contributor.researcheridL-6687-2018
dc.contributor.scopusid24376085300
dc.contributor.scopusid55853882900
dc.contributor.scopusid14067648200
dc.contributor.scopusid57506388900
dc.contributor.scopusid8234554800
dc.contributor.scopusid7004555373
dc.contributor.scopusid6602927353
dc.date.accessioned2022-09-05T06:46:53Z
dc.date.available2022-09-05T06:46:53Z
dc.date.issued2014-10
dc.description.abstractSuccessful cancer treatments still require more compounds to be isolated from natural sources. Thus, we have investigated anti-proliferative/apoptotic effects of methanolic extracts of lichen species Parmelia sulcata Taylor and Usnea filipendula Stirt on human lung cancer (A549, PC3), liver cancer (Hep3B) and rat glioma (C6) cells. Materials and methodsAnti-proliferative effects were monitored by MTT and adenosine triphosphate viability assays, while genotoxic activity was studied using the comet assay. Additionally, cell death mode and apoptosis assays (fluorescence staining, caspase-cleaved cytokeratin 18, caspase-3 activity and PARP cleavage) were performed. ResultsExtracts produced anti-population growth effects in a dose-dependent manner (1.56-100g/ml) by inducing apoptosis-like cell death. This resulted in the lines having the presence of pyknotic cell nuclei. In addition, significant increase in genetic damage in the cell lines was seen, indicating that DNA damage may have been responsible for apoptotic cell death. ConclusionIn this study, methanolic extracts of Parmelia sulcata and Usnea filipendula induced apoptosis-like cell death by causing DNA damage, to cancer cells.
dc.identifier.citationArı, F. vd. (2014). "Parmelia sulcata Taylor and Usnea filipendula Stirt induce apoptosis-like cell death and DNA damage in cancer cells". Cell Proliferation, 47(5), 457-464.
dc.identifier.endpage464
dc.identifier.issn0960-7722
dc.identifier.issn1365-2184
dc.identifier.issue5
dc.identifier.pubmed25081971
dc.identifier.scopus2-s2.0-84908653918
dc.identifier.startpage457
dc.identifier.urihttps://doi.org/10.1111/cpr.12123
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/full/10.1111/cpr.12123
dc.identifier.urihttp://hdl.handle.net/11452/28447
dc.identifier.volume47
dc.identifier.wos000341982600009
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherWiley
dc.relation.bapUAP(F)-2011/42
dc.relation.journalCell Proliferation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAntioxidant
dc.subjectLichen
dc.subjectChemotherapy
dc.subjectMetabolites
dc.subjectGrowth
dc.subjectCell biology
dc.subject.emtreeAntineoplastic agent
dc.subject.emtreeCaspase 3
dc.subject.emtreeCytokeratin 18
dc.subject.emtreeMethanol
dc.subject.emtreeNicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase
dc.subject.emtreeParmelia sulcata extract
dc.subject.emtreePlant extract
dc.subject.emtreeUnclassified drug
dc.subject.emtreeUsnea filipendula extract
dc.subject.emtreeAnimal cell
dc.subject.emtreeAntiproliferative activity
dc.subject.emtreeApoptosis
dc.subject.emtreeArticle
dc.subject.emtreeATPase activity assay
dc.subject.emtreeCancer cell
dc.subject.emtreeCancer cell line
dc.subject.emtreeCancer inhibition
dc.subject.emtreeCell death
dc.subject.emtreeCell nucleus
dc.subject.emtreeCell viability assay
dc.subject.emtreeComet assay
dc.subject.emtreeControlled study
dc.subject.emtreeDNA damage
dc.subject.emtreeDose response
dc.subject.emtreeEnzyme activity
dc.subject.emtreeFluorescence
dc.subject.emtreeGenotoxicity
dc.subject.emtreeHuman
dc.subject.emtreeHuman cell
dc.subject.emtreeMedicinal plant
dc.subject.emtreeMTT assay
dc.subject.emtreeNonhuman
dc.subject.emtreeParmelia sulcata
dc.subject.emtreeProtein cleavage
dc.subject.emtreeRat
dc.subject.emtreeUsnea
dc.subject.emtreeUsnea filipendula
dc.subject.emtreeAnimal
dc.subject.emtreeApoptosis
dc.subject.emtreeAscomycetes
dc.subject.emtreeBrain neoplasms
dc.subject.emtreeCell proliferation
dc.subject.emtreeDrug effects
dc.subject.emtreeEnzyme activation
dc.subject.emtreeGlioma
dc.subject.emtreeLiver neoplasms
dc.subject.emtreeLung neoplasms
dc.subject.emtreeMetabolism
dc.subject.emtreeNeoplasms
dc.subject.emtreeTumor cell line
dc.subject.meshAnimals
dc.subject.meshApoptosis
dc.subject.meshAscomycota
dc.subject.meshBrain neoplasms
dc.subject.meshCaspase 3
dc.subject.meshCell line, tumor
dc.subject.meshCell proliferation
dc.subject.meshDNA damage
dc.subject.meshEnzyme activation
dc.subject.meshGlioma
dc.subject.meshHumans
dc.subject.meshKeratin-18
dc.subject.meshLiver neoplasms
dc.subject.meshLung neoplasms
dc.subject.meshNeoplasms
dc.subject.meshPoly(ADP-ribose) polymerases
dc.subject.meshRats
dc.subject.meshUsnea
dc.subject.scopusUsnic Acid; Extract; Lichen (Disease)
dc.subject.wosCell biology
dc.titleParmelia sulcata Taylor and Usnea filipendula Stirt induce apoptosis-like cell death and DNA damage in cancer cells
dc.typeArticle
dc.wos.quartileQ2
dspace.entity.typePublication
local.contributor.departmentFen Edebiyat Fakültesi/Biyoloji Bölümü
local.contributor.departmentTıp Fakültesi/Biyokimya Ana Bilim Dalı
local.indexed.atScopus
local.indexed.atWOS

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