Publication:
The chondroprotective effects of intraarticular application of statin in osteoarthritis: An experimental study

dc.contributor.authorBayyurt, Sarp
dc.contributor.authorKüçükalp, Abdullah
dc.contributor.buuauthorBilgen, Muhammed Sadık
dc.contributor.buuauthorBilgen, Ömer Faruk
dc.contributor.buuauthorÇavuşoğlu, İlkin
dc.contributor.buuauthorYalçınkaya, Ulviye
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıbbi Patoloji Ana Bilim Dalı
dc.contributor.researcheridELH-9133-2022tr_TR
dc.contributor.researcheridCHS-2100-2022tr_TR
dc.contributor.researcheridCIC-4882-2022tr_TR
dc.contributor.researcheridAAH-8924-2021tr_TR
dc.contributor.scopusid35723877700tr_TR
dc.contributor.scopusid16933501900tr_TR
dc.contributor.scopusid6602910240tr_TR
dc.contributor.scopusid6508300295tr_TR
dc.date.accessioned2024-02-05T12:09:07Z
dc.date.available2024-02-05T12:09:07Z
dc.date.issued2015
dc.description.abstractBackground: Osteoarthritis (OA) is the most frequent chronic joint disease causing pain and disability. Recent reports have shown that statin may have the potential to inhibit osteoarthritis. This study of early stage OA developed in an experimental rabbit model, aimed to evaluate the chondroprotective effects of intraarticularly applied atorvastatin on cartilage tissue macroscopically and histopathologically by examining intracellular and extracellular changes by light and electron microscope. Materials and Methods: The experimental knee OA model was created by cutting the anterior cruciate ligament of the 20 mature New Zealand rabbits. The rabbits were randomly allocated into two groups of 10. Study group: The group that received intraarticular statin therapy; Control group: The group that did not receive any intraarticular statin therapy. The control group received an intraarticular administration of saline and the study group atorvastatin from the 1st week postoperatively, once a week for 3 weeks. The knee joints were removed including the femoral and tibial joint surfaces for light and electron microscopic studies of articular cartilages. Results: The mean total points obtained from the evaluation of the lesions that developed in the medial femoral condyle were 11.33 +/- 0.667 for the control group and 1.5 +/- 0.687 for the study group. The mean total points obtained from the evaluation of the lesions that developed in medial tibial plateau cartilage tissue were 11.56 +/- 0.709 for the control group and 1.40 +/- 0.618 for the study group. Electron microscopic evaluation revealed healthy cartilage tissue with appropriate chondrocyte and matrix structure in study group and impaired cartilage tissue in control group. Conclusion: Chondroprotective effect of statin on cartilage tissue was determined in this experimental OA model evaluated macroscopically and by light and electron microscope. There are some evidences to believe that the chondroprotective effect of the statin is that, by protecting the structure of the endoplasmic reticulum and the Golgi complex.en_US
dc.identifier.citationBayyurt, S. vd. (2015). "The chondroprotective effects of intraarticular application of statin in osteoarthritis: An experimental study". Indian Journal of Orthopaedics, 49(6), 665-671.en_US
dc.identifier.endpage671tr_TR
dc.identifier.issn0019-5413
dc.identifier.issue6tr_TR
dc.identifier.pubmed26806976tr_TR
dc.identifier.scopus2-s2.0-84948402159tr_TR
dc.identifier.startpage665tr_TR
dc.identifier.urihttps://doi.org/10.4103/0019-5413.168751en_US
dc.identifier.urihttps://link.springer.com/article/10.4103/0019-5413.168751en_US
dc.identifier.urihttps://hdl.handle.net/11452/39523en_US
dc.identifier.volume49tr_TR
dc.identifier.wos000365764300015
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.collaborationSanayitr_TR
dc.relation.journalIndian Journal of Orthopaedicsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOrthopedicsen_US
dc.subjectChondroprotective effecten_US
dc.subjectElectron microscopeen_US
dc.subjectExperimental osteoarthritisen_US
dc.subjectStatinen_US
dc.subjectRabbit experimental osteoarthritisen_US
dc.subjectArticular-cartilageen_US
dc.subjectInhibitionen_US
dc.subjectKneeen_US
dc.subject.scopusSimvastatin; Hydroxymethylglutaryl-coa reductase inhibitor; Asthmaen_US
dc.subject.wosOrthopedicsen_US
dc.titleThe chondroprotective effects of intraarticular application of statin in osteoarthritis: An experimental studyen_US
dc.typeArticleen_US
dc.wos.quartileQ4en_US
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Ortopedi ve Travmatoloji Ana Bilim Dalıtr_TR
local.contributor.departmentTıp Fakültesi/Histoloji ve Embriyoloji Ana Bilim Dalıtr_TR
local.contributor.departmentTıp Fakültesi/Tıbbi Patoloji Ana Bilim Dalıtr_TR

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