Publication:
The chondroprotective effects of intraarticular application of statin in osteoarthritis: An experimental study

dc.contributor.authorBayyurt, Sarp
dc.contributor.authorKüçükalp, Abdullah
dc.contributor.buuauthorBilgen, Muhammed Sadık
dc.contributor.buuauthorBilgen, Ömer Faruk
dc.contributor.buuauthorÇavuşoğlu, İlkin
dc.contributor.buuauthorYalçınkaya, Ulviye
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıbbi Patoloji Ana Bilim Dalı
dc.contributor.departmentOrtopedi ve Travmatoloji Ana Bilim Dalı
dc.contributor.departmentHistoloji ve Embriyoloji Ana Bilim Dalı
dc.contributor.researcheridELH-9133-2022
dc.contributor.researcheridCHS-2100-2022
dc.contributor.researcheridCIC-4882-2022
dc.contributor.researcheridAAH-8924-2021
dc.contributor.scopusid35723877700
dc.contributor.scopusid16933501900
dc.contributor.scopusid6602910240
dc.contributor.scopusid6508300295
dc.date.accessioned2024-02-05T12:09:07Z
dc.date.available2024-02-05T12:09:07Z
dc.date.issued2015
dc.description.abstractBackground: Osteoarthritis (OA) is the most frequent chronic joint disease causing pain and disability. Recent reports have shown that statin may have the potential to inhibit osteoarthritis. This study of early stage OA developed in an experimental rabbit model, aimed to evaluate the chondroprotective effects of intraarticularly applied atorvastatin on cartilage tissue macroscopically and histopathologically by examining intracellular and extracellular changes by light and electron microscope. Materials and Methods: The experimental knee OA model was created by cutting the anterior cruciate ligament of the 20 mature New Zealand rabbits. The rabbits were randomly allocated into two groups of 10. Study group: The group that received intraarticular statin therapy; Control group: The group that did not receive any intraarticular statin therapy. The control group received an intraarticular administration of saline and the study group atorvastatin from the 1st week postoperatively, once a week for 3 weeks. The knee joints were removed including the femoral and tibial joint surfaces for light and electron microscopic studies of articular cartilages. Results: The mean total points obtained from the evaluation of the lesions that developed in the medial femoral condyle were 11.33 +/- 0.667 for the control group and 1.5 +/- 0.687 for the study group. The mean total points obtained from the evaluation of the lesions that developed in medial tibial plateau cartilage tissue were 11.56 +/- 0.709 for the control group and 1.40 +/- 0.618 for the study group. Electron microscopic evaluation revealed healthy cartilage tissue with appropriate chondrocyte and matrix structure in study group and impaired cartilage tissue in control group. Conclusion: Chondroprotective effect of statin on cartilage tissue was determined in this experimental OA model evaluated macroscopically and by light and electron microscope. There are some evidences to believe that the chondroprotective effect of the statin is that, by protecting the structure of the endoplasmic reticulum and the Golgi complex.
dc.identifier.citationBayyurt, S. vd. (2015). "The chondroprotective effects of intraarticular application of statin in osteoarthritis: An experimental study". Indian Journal of Orthopaedics, 49(6), 665-671.
dc.identifier.endpage671
dc.identifier.issn0019-5413
dc.identifier.issue6
dc.identifier.pubmed26806976
dc.identifier.scopus2-s2.0-84948402159
dc.identifier.startpage665
dc.identifier.urihttps://doi.org/10.4103/0019-5413.168751
dc.identifier.urihttps://link.springer.com/article/10.4103/0019-5413.168751
dc.identifier.urihttps://hdl.handle.net/11452/39523
dc.identifier.volume49
dc.identifier.wos000365764300015
dc.indexed.scopusScopus
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherSpringer Heidelberg
dc.relation.collaborationSanayi
dc.relation.journalIndian Journal of Orthopaedics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectOrthopedics
dc.subjectChondroprotective effect
dc.subjectElectron microscope
dc.subjectExperimental osteoarthritis
dc.subjectStatin
dc.subjectRabbit experimental osteoarthritis
dc.subjectArticular-cartilage
dc.subjectInhibition
dc.subjectKnee
dc.subject.scopusSimvastatin; Hydroxymethylglutaryl-coa reductase inhibitor; Asthma
dc.subject.wosOrthopedics
dc.titleThe chondroprotective effects of intraarticular application of statin in osteoarthritis: An experimental study
dc.typeArticle
dc.wos.quartileQ4
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Ortopedi ve Travmatoloji Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Histoloji ve Embriyoloji Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Tıbbi Patoloji Ana Bilim Dalı
local.indexed.atWOS
local.indexed.atScopus

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