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Detection of fragile sites induced by pyrimethamine

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dc.contributor.buuauthorEgeli, Ünal
dc.contributor.buuauthorTunca, Berrin
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentFen Edebiyat Fakültesi
dc.contributor.departmentMoleküler Biyoloji Bölümü
dc.contributor.departmentTıbbi Biyoloji Ana Bilim Dalı
dc.contributor.orcid0000-0002-1619-6680
dc.contributor.researcheridABI-6078-2020
dc.contributor.scopusid55665145000
dc.contributor.scopusid6602965754
dc.date.accessioned2021-10-04T08:40:24Z
dc.date.available2021-10-04T08:40:24Z
dc.date.issued1997
dc.description.abstractIn this study, the effect of pyrimethamine in inducing expression of fragile sites in human peripheral blood lymphocyte cultures is investigated. In vitro lymphocyte cultures of 15 healthy individuals were treated with 0.02 mg/ml of pyrimethamine for 48 and 72 hr. One culture was used as control. The number of cells showing chromosomal aberration increases significantly in the cultures after 48 and 72 hr in comparison to the control group (P < 0.001). Localization of fragile sites was determined by the G-banding method and light microscopy. As a result, five folic acid-sensitive fragile sites (lp32, lq32. 3p14, 6p22, 14q24) were detected.
dc.identifier.citationEgeli, U. ve Tunca, B. (1997). "Detection of fragile sites induced by pyrimethamine". Teratogenesis Carcinogenesis and Mutagenesis, 17(2), 59-69.
dc.identifier.doi10.1002/(SICI)1520-6866(1997)17:2<59::AID-TCM2>3.0.CO;2-D
dc.identifier.endpage69
dc.identifier.issn0270-3211
dc.identifier.issue2
dc.identifier.pubmed9261920
dc.identifier.scopus2-s2.0-0030811917
dc.identifier.startpage59
dc.identifier.urihttps://doi.org/10.1002/(SICI)1520-6866(1997)17:2<59::AID-TCM2>3.0.CO;2-D
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/10.1002/(SICI)1520-6866(1997)17:2%3C59::AID-TCM2%3E3.0.CO;2-D
dc.identifier.urihttp://hdl.handle.net/11452/22214
dc.identifier.volume17
dc.identifier.wosA1997XN84000002
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherWiley
dc.relation.journalTeratogenesis Carcinogenesis and Mutagenesis
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectOncology
dc.subjectGenetics & heredity
dc.subjectToxicology
dc.subjectPyrimethamine
dc.subjectFragile site
dc.subjectLymphocyte culture
dc.subjectChromosomal aberrations
dc.subjectG-banding
dc.subjectHuman-chromosomes
dc.subjectDihydrofolate-reductase
dc.subjectCancer
dc.subjectMethotrexate
dc.subjectExpression
dc.subjectRearrangements
dc.subjectAberrations
dc.subject.emtreePyrimethamine
dc.subject.emtreeAdult
dc.subject.emtreeArticle
dc.subject.emtreeChromosome aberration
dc.subject.emtreeChromosome fragile site
dc.subject.emtreeControlled study
dc.subject.emtreeFemale
dc.subject.emtreeGenotoxicity
dc.subject.emtreeHuman
dc.subject.emtreeHuman cell
dc.subject.emtreeLymphocyte culture
dc.subject.emtreeMale
dc.subject.emtreePriority journal
dc.subject.meshAdult
dc.subject.meshAntimalarials
dc.subject.meshCell culture techniques
dc.subject.meshChromosome aberrations
dc.subject.meshChromosome banding
dc.subject.meshChromosome fragile sites
dc.subject.meshChromosome fragility
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshKaryotyping
dc.subject.meshLymphocytes
dc.subject.meshMale
dc.subject.meshPyrimethamine
dc.subject.scopusHyperpigmentation; Vitamin B 12 Deficiency; Megaloblastic Anemia
dc.subject.wosOncology
dc.subject.wosGenetics & heredity
dc.subject.wosToxicology
dc.titleDetection of fragile sites induced by pyrimethamine
dc.typeArticle
dc.wos.quartileQ4
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Tıbbi Biyoloji Ana Bilim Dalı
local.contributor.departmentFen Edebiyat Fakültesi/Moleküler Biyoloji Bölümü
local.indexed.atScopus
local.indexed.atWOS

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