Publication:
Routine use of prophylactic antibiotics during laparoscopic cholecystectomy does not reduce the risk of surgical site infections

dc.contributor.authorKılıçturgay, Sadık
dc.contributor.authorAktaş, Hikmet
dc.contributor.buuauthorSarkut, Pınar
dc.contributor.buuauthorÖzen, Yılmaz
dc.contributor.buuauthorKaya, Ekrem
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentGenel Cerrahi Ana Bilim Dalı
dc.contributor.orcid0000-0002-9562-4195
dc.contributor.researcheridAAG-7319-2021
dc.contributor.scopusid55806454400
dc.contributor.scopusid6508243334
dc.contributor.scopusid7004568109
dc.date.accessioned2023-01-30T12:29:23Z
dc.date.available2023-01-30T12:29:23Z
dc.date.issued2017-06
dc.descriptionBu çalışma, 22-24 Kasım 2012 tarihleri arasında İstanbul[Türkiye]’da düzenlenen 16. Annual Meeting of the European-Society-of-Surgery (ESS)’da bildiri olarak sunulmuştur.
dc.description.abstractBackground: Laparoscopic cholecystectomy (LC) is the gold standard for the treatment of symptomatic gallbladder stones. As infections are rare in uncomplicated LC, it is widely accepted that prophylactic antibiotics need not be administered, and guidelines do not support routine antibiotic prophylaxis during elective LC. However, routine antibiotic prophylaxis for elective LC is still popular in many clinical settings. We investigated this situation in our department. Method: This randomized double-blind controlled study included 570 patients who underwent LC between March 2007 and February 2010. The exclusion criteria were antibiotic intake before surgery, steroid treatment, and the presence of pancreatitis, cholangitis, obstructive jaundice, cephalosporin allergy, or pregnancy. The patients were randomized into three groups. Group 1 (n = 193) received physiologic saline as placebo, Group 2 (n = 191) received a first-generation cephalosporin (cefazolin; 1 g), and Group 3 (n = 186) received a second-generation cephalosporin (cefuroksim aksetil; 750mg). Bile and epigastric and umbilical port tissue samples were harvested for culture. All patients were observed until the end of the fourth week after surgery. Patient age, sex, weight, American Society of Anesthesiologists (ASA) score, diabetes mellitus, smoking history, history of biliary colic in the past month, length of the hospital stay before the operation, operational findings (acute or chronic cholecystitis), operation duration, use of drainage, type of prophylaxis administered if any, culture results, surgical site infection (SSI) development, and time to SSI development along with associated treatments were evaluated. Results: There was no statistically significant difference between the groups with respect to any of the demographic and clinical features analyzed in this study. The SSI rate was 1.2% in total, and in Groups 1, 2, and 3, it was 1.5%, 1.04%, and 1.07%, respectively. There was no statistical difference regarding SSI among the groups (p = 1.00). Superficial SSI was observed in all groups, and in all patients, the site of infection was the entrance to the epigastric port through which the gallbladder had been removed. Conclusions: Surgical site infection is rare after LC, and antibiotic prophylaxis does not appear to affect the outcome significantly. Moreover, factors such as positive bile cultures, history of biliary attack, ASA score, diabetes, obesity, and smoking do not have any effect on SSI development. Thus, we conclude that antibiotic prophylaxis is not needed for elective LC.
dc.description.sponsorshipEuropean Soc Surgery
dc.identifier.citationSarkut, P. vd. (2017). ''Routine use of prophylactic antibiotics during laparoscopic cholecystectomy does not reduce the risk of surgical site infections''. Surgical Infections, 18(5), 603-609.
dc.identifier.endpage609
dc.identifier.issn1096-2964
dc.identifier.issue5
dc.identifier.pubmed28375803
dc.identifier.scopus2-s2.0-85019694228
dc.identifier.startpage603
dc.identifier.urihttps://doi.org/10.1089/sur.2016.265
dc.identifier.urihttps://www.liebertpub.com/doi/10.1089/sur.2016.265
dc.identifier.uri1557-8674
dc.identifier.urihttp://hdl.handle.net/11452/30717
dc.identifier.volume18
dc.identifier.wos000404260600012
dc.indexed.wosSCIE
dc.indexed.wosCPCIS
dc.language.isoen
dc.publisherMary Ann Liebert
dc.relation.collaborationSanayi
dc.relation.journalSurgical Infections
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectInfectious diseases
dc.subjectSurgery
dc.subjectLaparoscopic cholecystectomy
dc.subjectProphylactic antibiotics
dc.subjectSurgical site infection
dc.subjectPostoperative infection
dc.subjectGallbladder perforation
dc.subjectPrevention
dc.subjectEfficacy
dc.subjectNeed
dc.subject.emtreeAntibiotic agent
dc.subject.emtreeCefazolin
dc.subject.emtreeCefuroxime axetil
dc.subject.emtreePlacebo
dc.subject.emtreeAntiinfective agent
dc.subject.emtreeAcute cholecystitis
dc.subject.emtreeAdult
dc.subject.emtreeAged
dc.subject.emtreeBacterial growth
dc.subject.emtreeBacterium isolate
dc.subject.emtreeBile
dc.subject.emtreeBiliary colic
dc.subject.emtreeCholelithiasis
dc.subject.emtreeChronic cholecystitis
dc.subject.emtreeConference Paper
dc.subject.emtreeControlled clinical trial;
dc.subject.emtreeControlled study
dc.subject.emtreeDiabetes mellitus
dc.subject.emtreeDouble blind procedure
dc.subject.emtreeDrug efficacy
dc.subject.emtreeElective surgery
dc.subject.emtreeEnterococcus faecalis
dc.subject.emtreeEnterococcus faecium
dc.subject.emtreeEscherichia coli
dc.subject.emtreeFemale
dc.subject.emtreeGram negative bacterium
dc.subject.emtreeHuman
dc.subject.emtreeHuman tissue
dc.subject.emtreeInfection prevention
dc.subject.emtreeInfection risk
dc.subject.emtreeLaparoscopic cholecystectomy
dc.subject.emtreeLength of stay
dc.subject.emtreeMajor clinical study
dc.subject.emtreeMale
dc.subject.emtreeMedical history
dc.subject.emtreeObesity
dc.subject.emtreeOperation duration
dc.subject.emtreePostoperative complication
dc.subject.emtreePreoperative period
dc.subject.emtreePriority journal
dc.subject.emtreeProphylaxis
dc.subject.emtreeRandomized controlled trial
dc.subject.emtreeRare disease
dc.subject.emtreeRisk assessment
dc.subject.emtreeRisk factor
dc.subject.emtreeRisk reduction
dc.subject.emtreeScoring system
dc.subject.emtreeSmoking
dc.subject.emtreeStaphylococcus epidermidis
dc.subject.emtreeStaphylococcus haemolyticus
dc.subject.emtreeSurgical drainage
dc.subject.emtreeSurgical infection
dc.subject.emtreeTissue culture
dc.subject.emtreeVery elderly
dc.subject.emtreeAdolescent
dc.subject.emtreeAntibiotic prophylaxis
dc.subject.emtreeBacterium
dc.subject.emtreeIsolation and purification
dc.subject.emtreeLaparoscopic cholecystectomy
dc.subject.emtreeMicrobiology
dc.subject.emtreeMiddle aged
dc.subject.emtreeStatistics and numerical data
dc.subject.emtreeSurgical wound infection
dc.subject.emtreeYoung adult
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshAged, 80 and over
dc.subject.meshAnti-bacterial agents
dc.subject.meshAntibiotic prophylaxis
dc.subject.meshBacteria
dc.subject.meshCholecystectomy
dc.subject.meshLaparoscopic
dc.subject.meshDouble-blind method
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshMiddle aged
dc.subject.meshSurgical wound infection
dc.subject.meshYoung adult
dc.subject.scopusAntibiotic Prophylaxis; Surgical Infection; Anti-Bacterial Agents
dc.subject.wosInfectious diseases
dc.subject.wosSurgery
dc.titleRoutine use of prophylactic antibiotics during laparoscopic cholecystectomy does not reduce the risk of surgical site infections
dc.typeArticle
dc.typeProceedings Paper
dc.wos.quartileQ4 (Infectious diseases)
dc.wos.quartileQ3 (Surgery)
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Genel Cerrahi Ana Bilim Dalı
local.indexed.atPubMed
local.indexed.atWOS

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