Topical xenogeneic exosome therapy in a dog with toxic epidermal necrolysis

Abstract

This report describes a positive outcome of topical exosome therapy for toxic epidermal necrolysis (TEN) in a dog. Enrofloxacin was administered subcutaneously one day before and for 7 days after the surgery for urolithiasis. Fourteen days after discontinuing the treatment, the dog was presented to the clinic for disseminated superficial tissue loss in the dorsal region which is associated with adverse drug reaction based on the scores for assessment of drug causality for epidermal necrolysis. Bovine-derived cord blood exosome was applied in the dose of 1 million/kg, twice a day, with intradermal and spraying routes to multiple points around the wound. The dog was monitored weekly, and complete recovery was observed 58 days after treatment. This report shows that topical xenogeneic exosome may be an alternative treatment approach for wound healing in dogs.