Publication:
Serum progranulin levels in axial spondyloarthropathy and relationship with clinical features

dc.contributor.authorDogangun, Didem Ildemir
dc.contributor.authorAksoy, Meliha Kasapoglu
dc.contributor.buuauthorAltan, Lale
dc.contributor.buuauthorALTAN İNCEOĞLU, LALE
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi.
dc.contributor.orcid0000-0003-4688-0464
dc.date.accessioned2024-06-24T12:25:45Z
dc.date.available2024-06-24T12:25:45Z
dc.date.issued2021-10-16
dc.description.abstractObjectives: In this study, we aimed to investigate the serum progranulin (PGRN) levels in patients with axial spondyloarthropathy (AxSpA) and to identify the correlation between disease activity, symptom severity, acute phase reactant (APR), and serum PGNR levels in patients with AxSpA. Patients and methods: This prospective, cross-sectional study included a total of 152 patients (105 males, 47 females; mean age: 41.8 +/- 10.3; range 20 to 65 years) with AxSpA according to the 2009 Assessment of SpondyloArthritis Society (ASAS) criteria who received treatment and 100 healthy individuals (61 males, 39 females; mean age 43.4 +/- 14.2; range 20 to 65 years) between February 2018 and February 2019. Serum PGRN levels from the venous blood were analyzed in both groups. The clinical AxSpA assessment scales were used in the patient group. Erythrocyte sedimentation rate and C-reactive protein levels were examined. Results: The mean serum PGRN level was 6.9 +/- 5.4 ng/mL in the patient group and 11.2 +/- 6.0 ng/mL in the control group. Serum PGRN level was significantly higher in the control group (p<0.001). No significant correlation was found between the PGRN levels and disease activity, symptom severity, duration of disease, and age of the patient (p>0.05). Serum PGRN levels were significantly higher in female patients in the patient group (p<0.01). In the control group, the serum PGRN levels of individuals with a high body mass index were significantly higher (p=0.001). Conclusion: Serum PGRN levels of patients with AxSpA who are under treatment and follow-up are significantly lower than healthy individuals. Serum PGRN levels in female patients with AxSpA are also significantly higher than male patients. Serum PGRN levels do not seem to be related to disease activity.
dc.identifier.doi10.46497/ArchRheumatol.2022.8542
dc.identifier.endpage118
dc.identifier.issue1
dc.identifier.startpage110
dc.identifier.urihttps://doi.org/10.46497/ArchRheumatol.2022.8542
dc.identifier.urihttps://hdl.handle.net/11452/42295
dc.identifier.volume37
dc.identifier.wos000735879700001
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherTurkish League Against Rheumatism
dc.relation.journalArchives Of Rheumatology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectC-reactive protein
dc.subjectAnkylosing-spondylitis
dc.subjectArthritis
dc.subjectValidity
dc.subjectMice
dc.subjectAcute phase reactants
dc.subjectAxial spondyloarthropathy
dc.subjectDisease activity
dc.subjectProgranulin
dc.subjectScience & technology
dc.subjectLife sciences & biomedicine
dc.subjectRheumatology
dc.subjectRheumatology
dc.titleSerum progranulin levels in axial spondyloarthropathy and relationship with clinical features
dc.typeArticle
dspace.entity.typePublication
relation.isAuthorOfPublication2aba29a4-d7c1-443c-8dec-31e291a1e5a8
relation.isAuthorOfPublication.latestForDiscovery2aba29a4-d7c1-443c-8dec-31e291a1e5a8

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