Yayın: Contingent role of phoenixin and nesfatin-1 on secretions of the male reproductive hormones
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Dosyalar
Tarih
2019-12
Kurum Yazarları
Güvenç, Gökçen
Altınbaş, Burçin
Kaşıkçı, Esra
Özyurt, Ebru
Baş, Ayşenur
Udum, Duygu
Niaz, Nasir
Yalçın, Murat
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayımcı
Wiley
Özet
Phoenixin (PNX) and nesfatin-1 are localised in the hypothalamus and the pituitary gland. Moreover, the most of the PNX-expressing neurons in the hypothalamus also co-express nesfatin-1. These outcomes may suggest that there is an interaction between PNX and nesfatin-1, at least in terms of neuroendocrine-mediated regulations. Hence, the study was planned to find out the effects of centrally delivered PNX and nesfatin-1 on male sex hormones or to show the interactive association of intracerebroventricularly (ICV) injected PNX+nesfatin-1 combination on the release of male hormones. PNX and nesfatin-1, single or together, were delivered ICV to different male Wistar Albino rat groups. Both PNX and nesfatin-1 induced a significant enhancement in plasma FSH, LH and testosterone without inducing any alteration in plasma GnRH in the rats. The central combinatorial treatment of both the neuropeptides produced a more potent rise in male plasma hormone levels than treating with single neuropeptide. In summary, our preliminary data show that centrally delivered PNX and nesfatin-1 can affect plasma male hormone levels. Moreover, that the combinatorial treatment with both the neuropeptides in male rats leading to a more potent effect on the plasma male hormone levels might suggest that both these neuropeptides act synergistically in terms of regulation of male HPGA.
Açıklama
Anahtar kelimeler
Hypothalamic-pituitary-gonadal axis, Intracerebroventricular, Male sex hormones, Nesfatin-1, Phoenixin, Luteinizing-hormone, Gonadotropin-secretion, Food-intake, Peptide, Brain, Nucb2/nesfatin-1, Testosterone, Neuropeptıde, Expressıon, Puberty