Publication:
Glial fibrillary acidic protein (GFAP) and CD34 expression in the human optic nerve and brain in methanol toxicity

dc.contributor.authorTürkmen, Nursel
dc.contributor.authorEren, Bülent
dc.contributor.authorFedakar, Recep
dc.contributor.authorAkgöz, Semra
dc.contributor.authorComunoglu, Nil
dc.contributor.buuauthorTÜRKMEN İNANIR, NURSEL
dc.contributor.buuauthorEren, Bülent
dc.contributor.buuauthorFEDAKAR, RECEP
dc.contributor.buuauthorAkgöz, Semra
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Adli Tıp Anabilim Dalı.
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.
dc.contributor.orcid0000-0002-2319-1757
dc.contributor.researcheridJGZ-0807-2023
dc.contributor.researcheridAAH-6287-2021
dc.contributor.researcheridACP-5545-2022
dc.contributor.researcheridAAK-8096-2021
dc.date.accessioned2024-10-24T11:41:54Z
dc.date.available2024-10-24T11:41:54Z
dc.date.issued2008-02-01
dc.description.abstractIntroduction: The toxicity of methanol is as a result of its metabolites, formaldehyde and formic acid. Formic acid induces severe metabolic acidosis causing death, and is the primary agent responsible for ocular toxicity. Glial fibrillary acidic protein ( GFAP) immunostaining is the most commonly used method for examining astrocyte proliferation and hypertrophy after various central nervous system injuries. The antigen CD34 is expressed widely on vascular endothelium, including that of the central nervous system and high endothelial venules.Methods: In this study, GFAP and CD34 were immunohistochemically localised in the post-mortem optic nerve head, and brain tissue ( basal ganglia putamen) samples were collected from methanol-exposed and non-methanol-exposed ( control) subjects.Results: There was a positive correlation between the GFAP and CD34 intensity of staining scores in the methanol-exposed group ( P=0.711, P=0.010). Furthermore, there was also a positive correlation between the brain putamen and optic nerve head GFAP extent of staining in the methanol-exposed group ( P=0.720, P=0.008). A statistically significant difference was found between the methanol-exposed group and the control group optic nerve CD34 intensity scores ( P=0.014), but no significant difference was found between optic nerve CD34 and GFAP extent scores ( P=0.05).Conclusion: The study revealed that methanol affects brain putamen and the optic nerve selectively. We detected a positive significant correlation between brain and optic nerve GFAP expression. CD34 expression was markedly decreased by the toxic effects of methanol.
dc.identifier.doi10.1007/s12325-008-0016-z
dc.identifier.endpage132
dc.identifier.issn0741-238X
dc.identifier.issue2
dc.identifier.startpage123
dc.identifier.urihttps://doi.org/10.1007/s12325-008-0016-z
dc.identifier.urihttps://link.springer.com/article/10.1007/s12325-008-0016-z
dc.identifier.urihttps://hdl.handle.net/11452/47017
dc.identifier.volume25
dc.identifier.wos000255873300006
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherSpringer
dc.relation.journalAdvances in Therapy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectChronic ethanol treatment
dc.subjectOcular toxicity
dc.subjectRats
dc.subjectImmunoreactivity
dc.subjectIntoxication
dc.subjectConsumption
dc.subjectExposure
dc.subjectTumors
dc.subjectBrain
dc.subjectCd34
dc.subjectGlial fibrillary acidic protein
dc.subjectImmunocytochemistry
dc.subjectOptic nerve
dc.subjectResearch & experimental medicine
dc.subjectPharmacology & pharmacy
dc.titleGlial fibrillary acidic protein (GFAP) and CD34 expression in the human optic nerve and brain in methanol toxicity
dc.typeArticle
dspace.entity.typePublication
relation.isAuthorOfPublicationb47dba7f-e6a6-4844-a4de-3d51ee5a82c4
relation.isAuthorOfPublication64310c17-8b59-40c0-8b34-8de15da2a3da
relation.isAuthorOfPublication.latestForDiscoveryb47dba7f-e6a6-4844-a4de-3d51ee5a82c4

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