Yayın: A short and efficient asymmetric synthesis of (±)-epi-cytoxazone from cis-(1R,2S,5R)-menthyl 4-methoxyphenylglycidates
Tarih
Kurum Yazarları
Coşkun, Necdet F.
Yazarlar
Er, Mustafa
Danışman
Dil
Türü
Yayıncı:
Springer
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Özet
The racemic epi-cytoxazone was synthesized, starting from p-anisaldehyde, in five steps and 48% overall yield. An efficient synthesis of azido alcohols has been achieved by regioselective ring opening of glycidates using NaN3 in MeOH-H2O. The key step of the process is reductive cyclization of azide carbonates by Zn-TMSCl.
Açıklama
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Anahtar Kelimeler:
Konusu
(±)-epi-cytoxazone, Zn-TMSCl reduction, 4-methoxyphenylglycidate, Darzen epoxidation, Azides, Stereoselective-synthesis, Cytokine modulator, (+)-epi-cytoxazone, Cytoxazone, (-)-cytoxazone, Pharmacology & pharmacy, Chemistry
Alıntı
Coşkun, N. F. ve Er, M. (2014). "A short and efficient asymmetric synthesis of (±)-epi-cytoxazone from cis-(1R,2S,5R)-menthyl 4-methoxyphenylglycidates". Chemistry of Natural Compounds, 50(6), 1071-1074.