Publication:
Hyperglycemia induced by intracerebroventricular choline: Involvement of the sympatho-adrenal system

dc.contributor.authorTaga, Yavuz
dc.contributor.buuauthorGürun, Mine Sibel
dc.contributor.buuauthorÖzarda, Yeşim
dc.contributor.buuauthorUlus, İsmail Hakkı
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentFarmakoloji ve Klinik Farmakoloji Ana Bilim Dalı
dc.contributor.departmentBiyokimya Ana Bilim Dalı
dc.contributor.researcheridAAL-8873-2021
dc.contributor.researcheridD-5340-2015
dc.contributor.researcheridAAG-8716-2019
dc.contributor.scopusid55664349700
dc.contributor.scopusid35741320500
dc.contributor.scopusid7004271086
dc.date.accessioned2021-12-08T07:17:51Z
dc.date.available2021-12-08T07:17:51Z
dc.date.issued2002-03-08
dc.description.abstractIntracerebroventricular (i.c.v.) injection of choline (75-300 mug) produced a dose-dependent increase in blood glucose levels. Pretreatment with the nicotinic acetylcholine receptor antagonist, mecamylamine (50 mug, i.c.v.) blocked the hyperglycemia induced by choline (150 mug, i.c.v.), but the response was not affected by pre-treatment with the muscarinic acetylcholine receptor antagonist, atropine (10 mug, i.c.v.). Pre-treatment with the neuronal choline uptake inhibitor, hemicholinium-3 (20 mug, i.c.v.), attenuated the hyperglycemia induced by choline. The hyperglycemic response to choline was associated increased plasma levels of adrenaline and noradrenaline. The hyperglycemia elicited by choline was greatly attenuated by bilateral adrenalectomy, and entirely blocked by either surgical transection of the splanchnic nerves or by pre-treatment with the a-adrenoceptor antagonist, phentolamine. These data show that choline, a precursor of acetylcholine, increases blood glucose and this effect is mediated by central nicotinic acetylcholine receptor activation. An increase in sympatho-adrenal activity appears to be involved in the hyperglycemic effect of choline.
dc.identifier.citationGürun, M. S. vd. (2002). "Hyperglycemia induced by intracerebroventricular choline: Involvement of the sympatho-adrenal system". European Journal of Pharmacology, 438(3), 197-205.
dc.identifier.endpage3
dc.identifier.issn0014-2999
dc.identifier.issue205
dc.identifier.pubmed11909612
dc.identifier.scopus2-s2.0-0037040425
dc.identifier.startpage438
dc.identifier.urihttps://doi.org/10.1016/S0014-2999(02)01312-2
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0014299902013122
dc.identifier.urihttp://hdl.handle.net/11452/23071
dc.identifier.volume197
dc.identifier.wos000174893500011
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherElsevier
dc.relation.collaborationYurt içi
dc.relation.journalEuropean Journal of Pharmacology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCholine
dc.subjectCholinergic activity
dc.subjectGlucoregulation
dc.subjectHyperglycemia
dc.subjectRat
dc.subjectSympatho-adrenal activity
dc.subjectNervous-system
dc.subjectHippocampal acetylcholine-releaser
dc.subjectRat corpus striatum
dc.subjectConscious ratsreverses hypotension
dc.subjectTyrosine-hydroxylase
dc.subjectAlzheimers-disease
dc.subjectGlucose injections
dc.subjectInduced decrease
dc.subjectCdp-choline
dc.subjectPharmacology & pharmacy
dc.subject.emtreeAdrenalin
dc.subject.emtreeNoradrenalin blood level
dc.subject.emtreeHemicholinium 3
dc.subject.emtreePropranolol
dc.subject.emtreeGlucose blood level
dc.subject.emtreeAtropine
dc.subject.emtreeCholine
dc.subject.emtreeMecamylamine
dc.subject.emtreeNoradrenalin
dc.subject.emtreeCarbachol glucose phentolamine
dc.subject.emtreeAdrenalectomy
dc.subject.emtreeAdrenalin blood level
dc.subject.emtreeAdrenergic system
dc.subject.emtreeAnimal model
dc.subject.emtreeArticle
dc.subject.emtreeControlled study
dc.subject.emtreeDose response
dc.subject.emtreeDrug effect
dc.subject.emtreeDrug efficacy
dc.subject.emtreeHyperglycemia
dc.subject.emtreeSplanchnic nerve
dc.subject.emtreeNerve transection
dc.subject.emtreeMale
dc.subject.emtreeNonhuman
dc.subject.emtreePriority journal
dc.subject.emtreeRat
dc.subject.meshAdrenalectomy
dc.subject.meshAdrenal glands
dc.subject.meshBlood glucose
dc.subject.meshDose-response relationship, drug
dc.subject.meshSympathetic nervous system
dc.subject.meshCholinergic agents
dc.subject.meshAnimals
dc.subject.meshTime factors
dc.subject.meshAtropine
dc.subject.meshNicotinic antagonists
dc.subject.meshCholine
dc.subject.meshEpinephrine
dc.subject.meshHemicholinium 3
dc.subject.meshHyperglycemia
dc.subject.meshInjections, intraventricular
dc.subject.meshMale
dc.subject.meshMecamylamine
dc.subject.meshNorepinephrine
dc.subject.meshPhentolamine
dc.subject.meshPropranolol
dc.subject.meshRats
dc.subject.meshRats, wistar
dc.subject.scopusCiticoline; Neuroprotective Agents; Glycerylphosphorylcholine
dc.subject.wosPharmacology & pharmacy
dc.titleHyperglycemia induced by intracerebroventricular choline: Involvement of the sympatho-adrenal system
dc.typeArticle
dc.wos.quartileQ2
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Biyokimya Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Farmakoloji ve Klinik Farmakoloji Ana Bilim Dalı
local.indexed.atPubMed
local.indexed.atWOS

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