Publication:
The effect of melatonin on lipid peroxidation during radiotherapy in female rats

dc.contributor.authorKaya, Hakan
dc.contributor.authorDelibaş, Namik
dc.contributor.authorSerteser, Mustafa
dc.contributor.authorOzkaya, Okan
dc.contributor.buuauthorUlukaya, Engin
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentBiyokimya Ana Bilim Dalı
dc.contributor.researcheridK-5792-2018
dc.date.accessioned2021-06-28T07:35:19Z
dc.date.available2021-06-28T07:35:19Z
dc.date.issued1999
dc.description.abstractBackground: Because radiotherapy is one of the causes of primary or secondary ovarian failure, protection of ovarian functions in the patients receiving total body or pelvic radiotherapy is of importance. In this study, we investigated the role of melatonin in the oxidative damage in both whole body and ovaries, which is caused by radiotherapy. Materials and Methods: Eighteen female rats were divided into 3 groups, each of which consisted of 6 rats. First group was control group receiving no treatment, second group received total body radiotherapy (RT) by 2 x 360 cGy only and third group received radiotherapy plus melatonin. Malondialdehyde (MDA) levels in both blood and ovarian tissue were detected as the indicator of free radical (FR) damage. Levels of erythrocyte superoxide dismutase (SOD) and glutathion peroxidase (GPX) in blood were measured as the indicators of antioxidant level. Results: Radiotherapy caused a significant increase in the levels of MDA in blood and ovarian tissue (p < 0.001). However, MDA levels decreased in the radiotherapy plus melatonin group (p < 0.05). SOD and GPX levels decreased insignificantly in the radiotherapy only group while they increased in the radiotherapy plus melatonin group significantly (p < 0.01 and p < 0.05, respectively). Conclusion: Melatonin, in rats, reduced the level of MDA, which is elevated by radiotherapy and increased the levels of SOD and GPX, which are involved in the antioxidant system.
dc.identifier.citationKaya, H. vd. (1999). "The effect of melatonin on lipid peroxidation during radiotherapy in female rats". Strahlentherapie und Onkologie, 175(6), 285-288.
dc.identifier.endpage288
dc.identifier.issn0179-7158
dc.identifier.issue6
dc.identifier.pubmed10392170
dc.identifier.scopus2-s2.0-0033002666
dc.identifier.startpage285
dc.identifier.urihttps://doi.org/10.1007/BF02743581
dc.identifier.urihttps://link.springer.com/article/10.1007/BF02743581
dc.identifier.urihttp://hdl.handle.net/11452/20862
dc.identifier.volume175
dc.identifier.wos000080891300007
dc.indexed.scopusScopus
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherUrban & Vogel
dc.relation.collaborationYurt içi
dc.relation.journalStrahlentherapie und Onkologie
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectFree radicals
dc.subjectMelatonin
dc.subjectTBI rat
dc.subjectInterleukin-2 plus melatonin
dc.subjectSubstances
dc.subjectRadicals
dc.subjectBiology
dc.subjectCancer
dc.subjectDamage
dc.subject.wosOncology
dc.subject.wosRadiology
dc.subject.wosNuclear medicine & medical imaging
dc.titleThe effect of melatonin on lipid peroxidation during radiotherapy in female rats
dc.typeArticle
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Biyokimya Ana Bilim Dalı
local.indexed.atPubMed
local.indexed.atScopus

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