Intrahepatic cholestasis of pregnancy: Relationship between bile acid levels and maternal and fetal complications

Abstract

Objective: Intrahepatic cholestasis of pregnancy (ICP) complicates pregnancies which is characterized by elevated serum bile acid levels. ICP increases maternal and fetal morbidities. This study was designed to determine the association of maternal and fetal complications and serum bile acid levels.Material and method: Maternal and fetal characteristics were analyzed from the medical records of 61 patients who gave birth following a pregnancy complicated with ICP between 2009 and 2013.Results: Eighty seven percent of 61 cases were singletons, and 13% of them were twins. Mean SBA level was 36 mu mol/L. Preterm birth rate among singletons and twin pregnancies were 24.5% and 62.5%, respectively. Mean SBA level in preterm birth group was statistically higher with respect to the term birth group (100.8 mu mol/L and 25.61 mu mol/L, respectively; p=0.001). No perinatal mortality associated with ICP was detected in the study group.Conclusion: Pregnant women with the ICP compose high-risk group in regard to fetal and maternal risks. Close follow-up of these patients is required due to increased risks such as preterm delivery, meconium staining and fetal death.