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Folic acid-conjugated cationic Ag2S quantum dots for optical imaging and selective doxorubicin delivery to HeLa cells

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dc.contributor.authorDuman, Fatma Demir
dc.contributor.authorKhodadust, Rouhullah
dc.contributor.authorUlukaya, Engin
dc.contributor.authorAcar, Havva Yağcı
dc.contributor.buuauthorErkısa, Merve
dc.contributor.buuauthorArı, Ferda
dc.contributor.departmentFen Edebiyet Fakültesi
dc.contributor.departmentBiyoloji Bölümü
dc.contributor.orcid0000-0002-3127-742X
dc.contributor.orcid0000-0002-6729-7908
dc.contributor.researcheridAAM-1001-2020
dc.contributor.researcheridAAG-7012-2021
dc.contributor.scopusid57126208900
dc.contributor.scopusid24376085300
dc.date.accessioned2022-12-22T08:49:01Z
dc.date.available2022-12-22T08:49:01Z
dc.date.issued2017-10
dc.description.abstractWe aim to develop folic acid ( FA)-conjugated cationic Ag2S near-infrared quantum dots (NIRQDs) for the delivery of doxorubicin (DOX) selectively to folate receptor (FR)-positive cancer cells to achieve enhanced drug efficacy and optical tracking in the NIR region. Materials & methods: Cationic Ag2S NIRQDs were decorated with FA using a PEG bridge and loaded with DOX. In vitro studies were performed on FR-positive human cervical carcinoma cells and FR-negative A549 cells. Results: Significantly higher uptake of DOX by human cervical carcinoma cells cells and a greater therapeutic effect along with a strong intracellular optical signal were obtained with DOX-loaded FA-conjugated Ag2S NIRQDs. Conclusion: These Ag2S NIRQDs are promising theranostic nanoparticles for receptor-mediated delivery of DOX with enhanced drug efficacy combined with optical imaging.
dc.identifier.citationDuman, F. D. vd. (2017). ''Folic acid-conjugated cationic Ag2S quantum dots for optical imaging and selective doxorubicin delivery to HeLa cells''. Nanomedicine, 12(19), 2319-2333.
dc.identifier.doi10.2217/nnm-2017-0180
dc.identifier.endpage2333
dc.identifier.issn1743-5889
dc.identifier.issue19
dc.identifier.pubmed28875744
dc.identifier.scopus2-s2.0-85030166267
dc.identifier.startpage2319
dc.identifier.urihttps://doi.org/10.2217/nnm-2017-0180
dc.identifier.urihttps://www.futuremedicine.com/doi/10.2217/nnm-2017-0180
dc.identifier.uri1748-6963
dc.identifier.urihttp://hdl.handle.net/11452/30045
dc.identifier.volume12
dc.identifier.wos000411843400004
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherFuture Medicine
dc.relation.bapBUAP(F)-2014/3
dc.relation.collaborationYurt içi
dc.relation.journalNanomedicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.relation.tubitak113Z164
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBiotechnology & applied microbiology
dc.subjectScience & technology - other topics
dc.subjectAg2S quantum dots
dc.subjectCancer therapy
dc.subjectDoxorubicin
dc.subjectNear-infrared imaging;
dc.subjectTargeting
dc.subjectDrug-deliveryhig
dc.subjectHly luminescent
dc.subjectCytotoxicity
dc.subjectFolate
dc.subjectCardiotoxicity
dc.subjectNanoparticles
dc.subjectApoptosis
dc.subjectAssay
dc.subjectTool
dc.subject.emtreeDoxorubicin
dc.subject.emtreeFolic acid
dc.subject.emtreeQuantum dot
dc.subject.emtreeSilver sulfide quantum dot
dc.subject.emtreeSulfide
dc.subject.emtreeUnclassified drug
dc.subject.emtreeAntineoplastic agent
dc.subject.emtreeDoxorubicin
dc.subject.emtreeDrug carrier
dc.subject.emtreeFluorescent dye
dc.subject.emtreeFolic acid
dc.subject.emtreeMacrogol
dc.subject.emtreeNanoconjugate
dc.subject.emtreeQuantum dot
dc.subject.emtreeSilver derivative
dc.subject.emtreeSilver sulfide
dc.subject.emtreeArticle
dc.subject.emtreeCervical cancer cell line
dc.subject.emtreeControlled study
dc.subject.emtreeCytotoxicity
dc.subject.emtreeDrug delivery system
dc.subject.emtreeDrug efficacy
dc.subject.emtreeDrug mechanism
dc.subject.emtreeDrug synthesis
dc.subject.emtreeDrug uptake
dc.subject.emtreeFluorescence imaging
dc.subject.emtreeHeLa cell line
dc.subject.emtreeHuman
dc.subject.emtreeHuman cell
dc.subject.emtreeIn vitro study
dc.subject.emtreeIntracellular signaling
dc.subject.emtreePriority journal
dc.subject.emtreeQuantum yield
dc.subject.emtreeA-549 cell line
dc.subject.emtreeApoptosis
dc.subject.emtreeCell culture technique
dc.subject.emtreeCell survival
dc.subject.emtreeChemistry
dc.subject.emtreeDrug release
dc.subject.emtreeFluorescence imaging
dc.subject.emtreeParticle size
dc.subject.emtreeProcedures
dc.subject.emtreeSurface property
dc.subject.emtreeHeLa cell line
dc.subject.meshA549 cells
dc.subject.meshAntineoplastic agents
dc.subject.meshApoptosis
dc.subject.meshCell culture techniques
dc.subject.meshCell survival
dc.subject.meshDoxorubicin
dc.subject.meshDrug carriers
dc.subject.meshDrug liberation
dc.subject.meshFluorescent dyes
dc.subject.meshFolic acid
dc.subject.meshHeLa cells
dc.subject.meshHumans
dc.subject.meshNanoconjugates
dc.subject.meshOptical imaging
dc.subject.meshParticle size
dc.subject.meshPolyethylene glycols
dc.subject.meshQuantum dots
dc.subject.meshSilver compounds
dc.subject.meshSurface properties
dc.subject.scopusNanocrystal; Cdte; Forster Resonance Energy Transfer
dc.subject.wosNanoscience & nanotechnology
dc.subject.wosBiotechnology & applied microbiology
dc.titleFolic acid-conjugated cationic Ag2S quantum dots for optical imaging and selective doxorubicin delivery to HeLa cells
dc.typeArticle
dc.wos.quartileQ1 (Biotechnology & applied microbiology)
dc.wos.quartileQ2 (Nanoscience & nanotechnology)
dspace.entity.typePublication
local.contributor.departmentFen Edebiyet Fakültesi/Biyoloji Bölümü
local.indexed.atPubMed
local.indexed.atWOS

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