Publication:
Severe aplastic anemia and a healthy pregnancy immediately following syngeneic transplantation: An extremely rare case report

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Date

2023-04-27

Authors

PINAR, İBRAHİM ETHEM
Pınar, İbrahim Ethem
Özkalemkaş, Fahir
Ersal, Tuba
Özkocaman, Vildan

Authors

Gürsoy, Vildan

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Elsevier Science Inc

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Abstract

Aplastic anemia is potentially fatal, particularly if the disease does not respond to immunotherapy and progresses to severe pancytopenia. Allogeneic hematopoietic stem cell transplant from an HLA-matched sibling donor, the first-line treatment in patients younger than 40 years, is used as a curative treatment option in severe aplastic anemia. The availability of an identical twin donor is infrequent, and there is limited experience in this context. Additionally, the choices for a conditioning regimen for a syngeneic transplant to prevent engraftment failure and the necessity of graft-vs-host disease prophylaxis are controversial. Although long-term survival gradually increases after an allogeneic hematopoietic stem cell transplant, hypogonadism and infertility are the main problems that significantly affect patients' quality of life. We present a patient diagnosed with severe aplastic anemia who has had a healthy pregnancy immediately after a syngeneic transplant.

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Stem-cell transplantation, Blood, Science & technology, Life sciences & biomedicine, Immunology, Surgery, Transplantation

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