Yayın: Does single, low-dose preoperative dexamethasone improve outcomes after colorectal surgery based on an enhanced recovery protocol? Double-blind, randomized clinical trial
Tarih
Kurum Yazarları
Kırdak, Türkay
Yılmazlar, Aysun
Kavun, Sinan
Ercan, İlker
Yılmazlar, Tuncay
Yazarlar
Danışman
Dil
Türü
Yayıncı:
Sage Publications
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Özet
Preoperative single, high-dose methylprednisolone administration improves postoperative outcomes after colonic surgery. Several randomized studies, including major surgeries, assessed various high-dose steroid regimens; however, evidence about the effect of administration of lower doses on postoperative outcomes in colorectal surgery is not available. The aim of the present study is to determine whether the administration of a single, low dose of dexamethasone before surgery would confer an outcome advantage after colorectal surgery. Thirty patients undergoing colorectal surgery were included in this randomized, double-blind study. Patients received 8 mg dexamethasone or serum physiologic preoperatively. Levels of Interleukin-6 and C-reactive protein, pain scores, postoperative nausea and vomiting, mobilization, complications, hospital stay, and readmissions were compared. Age, sex, indications, and operations were similar in both groups (P > 0.05). C-reactive protein and Interleukin-6 levels increased significantly postoperatively in each group (P < 0.05), but there were no differences between groups when compared (P > 0.05). There were also no significant differences between pain scores, bowel functions, mobilization, hospital stay, complication rates, and readmission rates between the two groups (P > 0.05). Preoperative 8 mg dexamethasone administration has no significant effect on reducing postoperative inflammatory response and also does not improve outcomes of colorectal. surgery.
Açıklama
Kaynak:
Anahtar Kelimeler:
Konusu
Laparoscopic cholecystectomy, Inflammatory response, Cytokine response, Surgical stress, Cancer, Rehabilitation, Muscularis, Morbidity, Nausea, Surgery, Resection
Alıntı
Kırdak, T. vd. (2008). ''Does single, low-dose preoperative dexamethasone improve outcomes after colorectal surgery based on an enhanced recovery protocol? Double-blind, randomized clinical trial''. American Surgeon, 74(2), 160-167