Yayın:
Does single, low-dose preoperative dexamethasone improve outcomes after colorectal surgery based on an enhanced recovery protocol? Double-blind, randomized clinical trial

Placeholder

Tarih

Akademik Birimler

Kurum Yazarları

Kırdak, Türkay
Yılmazlar, Aysun
Kavun, Sinan
Ercan, İlker
Yılmazlar, Tuncay

Yazarlar

Danışman

Dil

Türü

Yayıncı:

Sage Publications

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Özet

Preoperative single, high-dose methylprednisolone administration improves postoperative outcomes after colonic surgery. Several randomized studies, including major surgeries, assessed various high-dose steroid regimens; however, evidence about the effect of administration of lower doses on postoperative outcomes in colorectal surgery is not available. The aim of the present study is to determine whether the administration of a single, low dose of dexamethasone before surgery would confer an outcome advantage after colorectal surgery. Thirty patients undergoing colorectal surgery were included in this randomized, double-blind study. Patients received 8 mg dexamethasone or serum physiologic preoperatively. Levels of Interleukin-6 and C-reactive protein, pain scores, postoperative nausea and vomiting, mobilization, complications, hospital stay, and readmissions were compared. Age, sex, indications, and operations were similar in both groups (P > 0.05). C-reactive protein and Interleukin-6 levels increased significantly postoperatively in each group (P < 0.05), but there were no differences between groups when compared (P > 0.05). There were also no significant differences between pain scores, bowel functions, mobilization, hospital stay, complication rates, and readmission rates between the two groups (P > 0.05). Preoperative 8 mg dexamethasone administration has no significant effect on reducing postoperative inflammatory response and also does not improve outcomes of colorectal. surgery.

Açıklama

Kaynak:

Anahtar Kelimeler:

Konusu

Laparoscopic cholecystectomy, Inflammatory response, Cytokine response, Surgical stress, Cancer, Rehabilitation, Muscularis, Morbidity, Nausea, Surgery, Resection

Alıntı

Kırdak, T. vd. (2008). ''Does single, low-dose preoperative dexamethasone improve outcomes after colorectal surgery based on an enhanced recovery protocol? Double-blind, randomized clinical trial''. American Surgeon, 74(2), 160-167

Endorsement

Review

Supplemented By

Referenced By

0

Views

0

Downloads