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Investigation of ABCB1 gene polymorphism with colchicine response in Behçet's disease

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dc.contributor.buuauthorSarıcaoğlu, Hayriye
dc.contributor.buuauthorYılmaz, Mediha
dc.contributor.buuauthorKarkucak, Mutlu
dc.contributor.buuauthorÖztürk, Hülya Z.Y.
dc.contributor.buuauthorYakut, Tahsin
dc.contributor.buuauthorGülten, Tuna
dc.contributor.buuauthorBülbül, Emel Başkan
dc.contributor.buuauthorAydoğan, Kenan
dc.contributor.buuauthorDilek, Kamil
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentRomatoloji Ana Bilim Dalı
dc.contributor.departmentDermatoloji Ana Bilim Dalı
dc.contributor.departmentTıbbi Genetik Ana Bilim Dalı
dc.contributor.orcid0000-0002-0144-3263
dc.contributor.researcheridAAH-1388-2021
dc.contributor.scopusid6603722836
dc.contributor.scopusid35148700000
dc.contributor.scopusid35388323500
dc.contributor.scopusid57197115377
dc.contributor.scopusid6602802424
dc.contributor.scopusid6505944216
dc.contributor.scopusid6602518817
dc.contributor.scopusid9739755800
dc.contributor.scopusid56005080200
dc.date.accessioned2021-12-29T12:03:21Z
dc.date.available2021-12-29T12:03:21Z
dc.date.issued2011
dc.description.abstractColchicine is commonly used in the treatment of Behcet's disease. However, some patients are unresponsive to colchicine treatment. Adenosine triphosphate-binding cassette subfamily B member 1 (ABCB1) transports colchicine out of cells. We investigated a possible association of C3435T polymorphism of the ABCB1 (MDR1) gene with colchicine response in patients with Behcet's disease. We randomly selected 97 patients with Behcet's disease, examined ABCB1 (MDR1) gene C3435T polymorphisms, and evaluated patient responses to colchicine. Forty-three patients were colchicine responsive, while the remaining 54 patients were unresponsive. No significant difference was found between genotypic and allelic frequencies of the ABCB1 C3435T polymorphisms in patients with Behcet's disease and healthy volunteers. Also, there was no significant difference among responsive and nonresponsive patients. We concluded that ABCB1 C3435T polymorphism is not associated with a colchicine response in patients with Behcet's disease.
dc.identifier.citationSarıcaoğlu, H. vd. (2011). "Investigation of ABCB1 gene polymorphism with colchicine response in Behçet's disease". Genetics and Molecular Research, 10(1), 1-6.
dc.identifier.endpage6
dc.identifier.issn1676-5680
dc.identifier.issue1
dc.identifier.pubmed21218380
dc.identifier.scopus2-s2.0-79251515771
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.4238/vol10-1gmr824
dc.identifier.urihttp://www.funpecrp.com.br/gmr/year2011/vol10-1/pdf/gmr824.pdf
dc.identifier.urihttp://hdl.handle.net/11452/23737
dc.identifier.volume10
dc.identifier.wos000286527300001
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherFunpec-Editora
dc.relation.journalGenetics and Molecular Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBiochemistry & molecular biology
dc.subjectGenetics & heredity
dc.subjectBehcet's disease
dc.subjectColchicine
dc.subjectABCB1 gene
dc.subjectPolymorphism
dc.subjectFamilial mediterranean fever
dc.subjectMultidrug-resistance gene
dc.subjectP-glycoprotein
dc.subjectClinical-relevance
dc.subjectMdr1
dc.subjectAssociation
dc.subjectEfficacy
dc.subject.emtreeColchicine
dc.subject.emtreeMultidrug resistance protein 1
dc.subject.emtreeAdult
dc.subject.emtreeArticle
dc.subject.emtreeBehcet disease
dc.subject.emtreeDiarrhea
dc.subject.emtreeDrug withdrawal
dc.subject.emtreeFemale
dc.subject.emtreeGene frequency
dc.subject.emtreeGenetic association
dc.subject.emtreeGenetic polymorphism
dc.subject.emtreeGenotype
dc.subject.emtreeHuman
dc.subject.emtreeLeukopenia
dc.subject.emtreeLiver dysfunction
dc.subject.emtreeMajor clinical study
dc.subject.emtreeMale
dc.subject.emtreeRandomized controlled trial
dc.subject.emtreeSide effect
dc.subject.emtreeStomach disease
dc.subject.emtreeTreatment response
dc.subject.meshAdult
dc.subject.meshBehcet syndrome
dc.subject.meshCase control studies
dc.subject.meshColchicine
dc.subject.meshFemale
dc.subject.meshGene frequency
dc.subject.meshGenotype
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshMiddle aged
dc.subject.meshP-glycoprotein
dc.subject.meshPolymorphism, single nucleotide
dc.subject.scopusMDR Gene; Multidrug Resistance Protein 1; Restriction Fragment Length Polymorphisms
dc.subject.wosBiochemistry & molecular biology
dc.subject.wosGenetics & heredity
dc.titleInvestigation of ABCB1 gene polymorphism with colchicine response in Behçet's disease
dc.typeArticle
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Tıbbi Genetik Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Dermatoloji Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Romatoloji Ana Bilim Dalı
local.indexed.atScopus
local.indexed.atWOS

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